Synthesis, Characterization, Antimalarial and Antimicrobial activities of Mixed Ibuprofen-Pyrimethamine M(II) Complexes [M = Cd, Co, Zn, Mn]

Year 2019, , 30 - 37, 31.12.2019

Mercy Bamigboye , İkechukwu Ejidike

https://doi.org/10.38061/idunas.629389

Cited By: 1

Abstract

Mixed complexes of
Ibuprofen-Pyrimethamine were synthesized using Cd(II) Co(II), Zn(II) and
Mn(II). The mixed complexes were characterized based on some physico-chemical
and spectroscopic techniques such as infrared, elemental analysis, conductivity
measurements, and magnetic moment. Based on the results obtained, the complexes
were formulated as [M(L₁)(L₂)]Cl₂ , where M =
metal ion, L₁ = Pyrimethamine, L₂ = Ibuprofen). The
complexes were found to be non-electrolytes. The ligands act as bidentate
towards the central metal ions with deprotonation occurring at the carboxylic
group. The complexes were also analyzed by conductometric titration.
Antimicrobial screening against the selected organisms: Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus substilis, Bacillus
megaterium and Serratia marcescens for the complexes
alongside the free ligands was investigated. Antimalarial study was
investigated for the compounds against Plasmodium
berhei (NK 65 strain). It was observed that the complexes showed
significant potentials against the studied organisms.

Keywords

Ibuprofen, Antimicrobial, Pyrimethamine, Metal Complexes

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