Investigation of the Association of Homocysteine and MTHFR Polymorphisms and Treatment Options in Parkinson’s disease in Turkey

Year 2015, Volume: 3 Issue: 3, 98 - 105, 30.05.2016

Ramazan Emre , Serhat Özkan , Kemal Cantürk , Hüseyin Aslan Muhsin Özdemir , Özgür Aldemir Mehmet Celayir Muhammed Müslümanoğlu

Abstract

Aim In this study, we aimed to investigate the effects of MTHFR C677T and A1298C polymorphisms to homocysteine levels in patients with Parkinson's disease who were treated with levodopa and entekapone.
Material and Methods Plasma homocysteine (hcy), folat and vitamin B12 and MTHFR (C677T, A1298C) polymorphisms and treatment options were compared in 70 Parkinson's Disease (PD) patients whom taking levodopa (n=26), dopamine agonist (n=11) and levodopa and entacapone treatment together (n=33) with 100 controls.
Results Although no statistically significant difference was detected, hcy level of the patients was found higher compared to control group (patient 18.29 ± 9.22 µmol /l vs control 15.77 ± 7.58 µmol / l; p> 0,05) and hcy level was highest in the patients receiving only levodopa, too (19.56 ± 10.77 µmol / l; p> 0,05). The frequency of TT genotype in the patients was higher compared to the control group (11.4%, 6%, P < 0.05). Especially, hcy level for levodopa-receiving patients with 677TT genotype was become significantly higher level when compared with other genotypes of levodopa-receiving patients (respectively 677TT 36.28 ± 16.17, 677CT 13.5 ± 1.71, 677CC 17.2 ± 6.59 P < 0.01). No statistically significant difference was detected between patients and controls regarding their folat and vitamin B12 levels and A1298C polymorphism (p> 0, 05).
Conclusions Finally, we concluded that both 677TT genotype and levodopa treatment might be jointly contributed to the increasing of the plasma hcy levels in PD patients and entacapone limitedly decreased hcy levels during levodopa treatment but results need to be confirmed with larger sample sized comprehensive studies.

Keywords

Anahtar levodopa, hiperhomosisteinemi

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