Antioxidant Activities of Bingöl Royal Jelly on SH-SY5Y Cells

Year 2021, Volume: 5 Issue: 2, 61 - 69, 01.12.2021

Eray Çalışkan , Adnan Ayna , Abdullah Tunç , Sedanur Özbolat , A. Şükrü Bengü , Gürkan Aykutoğlu , Mehmet Çiftci , Ekrem Darendelioğlu

https://doi.org/10.47947/ijnls.1008223

Cited By: 1

Abstract

Royal Jelly is a bee product with high protein content is a unique nutrient for the queen honeybee. It leads to a substantial elongation of the lifetime of the queen in comparison to the worker honeybees via anti-inflammatory, anti-oxidant, anti-cancer and anti-microbial properties. Flavonoids naturally have reported to have anticancer activities thanks to their potent antioxidant activity. The antioxidant activity of RJ is attributed to its rich flavonoid content however anti-oxidant activities of the Bingöl RJ has yet to be explored in detail. The goal of the current study was to investigate the antioxidant activities of Bingöl RJ on SH-SY5Y neuroblastoma cells. The results of our study revealed that Bingöl RJ at a concentration of 0.3 mg/ml significantly augmented ROS level in SH-SY5Y cells while 0.5 mg/ml of RJ had almost no effect on ROS levels. The levels of malondialdehyde in SH-SY5Y cells considerably increased in the presence of 0.3 mg/ml RJ while 0.5 mg/ml RJ had no significant impact on MDA levels in SH-SY5Y cells. The results showed that RJ treatment 0.3 mg/ml) significantly lowered the activities of SOD and CAT activity while 0.5 mg/ml of RJ had negligible effect indicating that RJ could protect the cell membranes from radical mediated cell injuries.

Keywords

Royal Jelly, SH-SY5Y, Catalase, Antioxidant, Flavonoids

Supporting Institution

Bingol University

Project Number

Project Number: 2017K124000-BÜBAP-PİKOM-Arı.2018.001

Thanks

This study was financially supported by Presidency of The Republic of Turkey Strategy and Budget Presidency (Former Development Ministry), coordinated by Council of Higher Education and organized by The Scientific Research Projects Coordination Unit of Bingol University (Project Number: 2017K124000-BÜBAP-PİKOM-Arı.2018.001).

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