Sium sisarum L. var. lancifolium (M. Bieb.) Thell -a traditional spice from eastern Anatolia: chemical composition and biological activities

Year 2022, Volume: 9 Issue: 3, 268 - 277, 26.09.2022

Muzaffer Mükemre , Abdullah Dalar , Şengal Bağci Taylan Metin Ertaş

https://doi.org/10.21448/ijsm.1066904

Cited By: 1

Abstract

Traditionally consumed food and spices are significant sources in the daily life diet and constitute a large portion of the cuisine in Eastern Anatolia in Turkey. However, limited data available necessitate further analysis of their chemical composition and health attributing properties. This study aims to present phytochemical composition and biological activities of Sium sisarum var. lancifolium, a commonly consumed spice and food species in the region. Analytical studies to date have revealed the presence of high levels of phenolics (chlorogenic acid and isoquercetin) and volatiles (α-terpinene, camphene, cyclohexene, carene and p-cymene), which exhibits significant potential of digestive enzyme suppressive and antioxidant abilities. Data collected in this study suggest the use of Sium sisarum plant to obtain nutraceuticals and/or biotherapeutic agents that are able to regulate oxidative stress and enzyme activities.

Keywords

Sium sisarum var. lancifolium, Antioxidant, α-Glucosidase, Pancreatic lipase, Phenolics

Supporting Institution

Hakkari University Scientific Research Projects Council

Project Number

FM20BAP7

Thanks

The authors are grateful to the Hakkari University Scientific Research Projects Council for providing financial assistance of the research

References

• Agoramoorthy, G., Chandrasekaran, M., Venkatesalu, V., & Hsu, M.J. (2007). Antibacterial and antifungal activities of fatty acid methyl esters of the blind-your-eyemangrove from India. Braz. J Microbiol., 38, 739–742. https://doi.org/10.1590/S1517-83822007000400028
• Akata, I., Zengin, G., Picot, CMN., & Mahomoodally, MF. (2019). Enzyme inhibitory and antioxidant properties of six mushroom speciesfrom the Agaricaceae family. South Afric. J Bot., 120, 95–99. https://doi.org/10.1016/j.sajb.2018.01.008
• Ashraf, M., Sandra, P.J., Saeed, T., & Bhatty, MK. (1999). Studies on the essential oils of the Pakistani species of the family Umbelliferae. Part 27. Sium latigujum C.B. Clark (Theem) seed oil. Pak. J Sci. Ind. Res., 22(4), 202-204.
• Baytop, T. (1999). Türkiye’de Bitkiler ile Tedavi. Nobel Tıb Kitabevleri, İstanbul.
• Cho, A.S., Jeon, SM., Kim, M.J., Yeo, J., Seo, K.I., Choi, M.S., & Lee, M.K. (2010). Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet induced obese mice. Food Chem Toxicol, 48(3), 937 43. https://doi.org/10.1016/j.fct.2010.01.003
• Cruz-Zuniga, J.M., Soto-Valdez, H., Peralta, E., Mendoza-Wilson, A.M., Robles-Burgueno, M.R., Auras, R., & Gamez-Meza, N. (2016). Development of an antioxidant biomaterial by promoting the deglycosylation of rutin to isoquercetin and quercetin. Food Chem., 204, 420–426. https://doi.org/10.1016/j.foodchem.2016.02.130
• Dalar, A., Türker, M., & Konczak, I. (2012). Antioxidant capacity and phenolic constituents of Malva neglecta Wallr. and Plantago lanceolata L. from Eastern Anatolia Region of Turkey. J.Herb.Med., 2, 42-51. https://doi.org/10.1016/j.hermed.2012.03.001
• Dalar, A., & Konczak, I. (2013). Phenolic contents, antioxidant capacities and inhibitory activities against key metabolic syndrome relevant enzymes of herbal teas from Eastern Anatolia. Ind. Crops Prod., 44, 383-390. https://doi.org/10.1016/j.indcrop.2012.11.037
• Dalar, A., Türker, M., Zabaras, D., & Konczak, I. (2014). Phenolic composition, antioxidant and enzyme inhibitory activities of Eryngium bornmuelleri leaf. Plant Foods Hum Nutr., 69, 30-36. https://doi.org/10.1007/s11130-013-0393-6
• Dalar, A., & Mükemre, M. (2020). Traditional Medicinal Plants of Van Province, Eastern Anatolia. NOVA Science Publishers Inc.
• Davis, P. (1965-1985). Flora of Turkey and East Aegean Islands. Edinburgh University Press. Vol. 1-9., Edinburgh.
• Dinis, T.C.P., Madeira, V.M.C., & Almeida, M.L.M. (1994). Action of phenolic derivates (acetoaminophen, salycilate and 5-aminosalycilate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Arch. Biochem Biophys., 315, 161-169. https://doi.org/10.1006/abbi.1994.1485
• El Tahir, K.E.H., Al-Ajmi, M.F., & Al-Bekairi, A.M. (2003). Some cardiovascular effects of the dethymoquinonated Nigella sativa volatile oil and its major components α-pinene and p-cymene in rats. Saudi Pharm J., 113, 104-110.
• Exteberria, U., Garza, A.L., Campiόn, J., Martinez, J.A., & Milagro, F.I. (2012). Antidiabetic effects of natural plant extracts via inhibition of carbonhydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase. Expert Opin Ther Targets, 16(3), 269-297. https://doi.org/10.1517/14728222.2012.664134
• Firenzuoli, F., & Gori, L. (2007). Herbal Medicine Today: Clinical and Research Issues. Evid Based Complement Alternat Med., 4, 37-40. https://doi.org/10.1093/ecam/nem096
• Gonçalves, S., Moreira, E., Grosso, C., Andrade, P.B., Valentão, P., & Romano, A. (2017). Phenolic profile, antioxidant activity and enzyme inhibitory activities of extracts from aromatic plants used in Mediterranean diet. J food Sci Technol., 54(1), 219–227. https://doi.org/10.1007/s13197-016-2453-z
• Harvey, J. (1984). Vegetables in the Middle Ages. Garden History 12(2), 89-99. https://doi.org/10.2307/1586800.
• Jayachandran, M., Wu, Z., Ganesan, K., Khalid, S., Chung, S.M., & Xu, B. (2019). Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats. Chem Biol interact., 303, 62–69. https://doi.org/10.1016/j.cbi.2019.02.017
• Kaval, İ., Behçet, L., & Çakılcıoglu, U. (2014). Ethnobotanical study on medicinal plants in Geçitli and its surrounding (Hakkari-Turkey). J Ethnopharmacol., 155, 171–184. https://doi.org/10.1016/j.jep.2014.05.014
• Konczak, I., Yoshimoto, M., Hou, D-X., Terahara, N., & Yamakawa, O. (2003). Potential Chemopreventive Properties of Anthocyanin-rich Aqueous Extracts from in vitro Produced Tissue of Sweetpotato (Ipomoea batatas L.). J Agric. Food Chem., 51, 5916-5922. https://doi.org/10.1021/jf030066o
• Lahlou, S., Interaminense, L.F., Leal-Cardoso, J.H., & Duarte, G.P. (2003). Antihypertensive effects of the essential oil of Alpinia zerumbet and its main constituent, terpinen-4-ol, in DOCA-salt hypertensive conscious rats. Fundam Clin Pharmacol., 17(3), 323–330. https://doi.org/10.1046/j.1472-8206.2003.00150.x
• Lee, J.Y., Kim, Y.S., & Shin, D.H. (2002). Antimicrobial synergistic effect of linolenic acidand monoglyceride against Bacillus cereus and Staphylococcus aureus. J Agric. Food Chem., 50, 2193–2199. https://doi.org/10.1021/jf011175a
• Mai, T.T., Thu, N.N., Tien, P.G., & Chuyen, N.V. (2007). Alpha-glucosidase inhibitory and antioxidant activities of Vietnamese edible plants and their relationships with polyphenol contents. J Nutr Sci Vitaminol, 53, 267-276. https://doi.org/10.3177/jnsv.53.267
• Mükemre, M., Behçet, L., & Çakılcıoglu, U. (2015). Ethnobotanical study on medicinal plants in villages of Çatak (Van Turkey). J Ethnopharmacol., 166, 361 374. https://doi.org/10.1016/j.jep.2015.03.040
• Pham-Huy, L. A., He, H., & Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. Int J Biomed Sci.: IJBS, 4(2), 89-96.
• Robinson, M.M., & Zhang, X. (2011). The world medicines situation 2011 (Traditional medicines: global situations, issues and challenges). Third edition. World Health Organization (WHO), Geneva, Italy.
• Oboh, G., Agunloye, O.M., Adefegha, S.A., Akinyemi, A.J., & Ademiluyi, A.O. (2015). Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): a comparative study. J Basic Clin Physiol Pharmacol, 26(2), 165 170. https://doi.org/10.1515/jbcpp-2013-0141
• Ozturk, O., Demirci, B., Duran, A., Altınordu, F., & Can Baser, K.H. (2017). Chemical composition and antioxidant activity of Sium sisarum essential oils. Nat. Volatiles & Essent. Oils, 4(1), 29-32.
• Sakulnarmrat, K., & Konczak, I. (2012). Composition of native Australian herbs polyphenolic-rich fractions and in vitro inhibitory activities against key enzymes relevant to metabolic syndrome. Food Chem., 134(2), 1011 1019. https://doi.org/10.1016/j.foodchem.2012.02.217
• Samancıoğlu, A., Sat, I.G., Yıldırım, E., Ercişli, S., Jurikova, T., & Mlcek, J. (2016). Total phenolic and vitamin C content and antiradical activity evaluation of traditionally consumed wild edible vegetables from Turkey. IJTK, 15(2), 208-213.
• Styskal, J., Van Remmen, H., Richardson, A., & Salmon, A.B. (2012). Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?. Free Radic Biol med., 52(1), 46–58. https://doi.org/10.1016/j.freeradbiomed.2011.10.441
• Uzun, Y., Dalar, A., & Konczak, I. (2017). Sempervivum davisii: phytochemical composition, antioxidant and lipase inhibitory activities. Pharm Biol. 55, 532 540. https://doi.org/10.1080/13880209.2016.1255979
• Weiss, R., Bremer, A., & Lusting, R. (2013). What is metabolic syndrome, and why children getting it?. Ann N Y Acad Sci., 1281, 123-40. https://doi.org/10.1111/nyas.12030
• Zhang, R., Yao, Y., Wang, Y., & Ren, G. (2011). Antidiabetic activity of isoquercetin in diabetic KK -A y mice. Nutr Metab., 8, 85 (2011). https://doi.org/10.1186/1743-7075-8-85
• Zhang, B., Deng, Z., Ramdath, D.D., Tang, Y., Chen, P.X., Liu, R., Liu, Q., & Tsao, R. (2015). Phenolic profiles of 20 Canadian lentil cultivars and their contribution to antioxidant activity and inhibitory effects on α-glucosidase and pancreatic lipase. Food Chem., 172, 862-872. https://doi.org/10.1016/j.foodchem.2014.09.144
• Zengin, G. (2016). A study on in vitro enzyme inhibitory properties of Asphodeline anatolica: new sources of natural inhibitors for public health problems. Ind. Crops Prod., 83, 39-43. https://doi.org/10.1016/j.indcrop.2015.12.033