Investigation of In Vitro antiproliferative activity properties of Spartium junceum L. (Spanish broom) against MDA-MB-231 and HepG2 cancer cell lines

Year 2023, Volume: 10 Issue: 3, 345 - 353, 27.08.2023

Fatma Tuğçe Gürağaç Dereli , Senem Akkoç

https://doi.org/10.21448/ijsm.1182965

Abstract

Cancer is among the top global public health burdens leading to millions of deaths each year. The study aims to investigate the antiproliferative effect of Spartium junceum L. flowers on different cancer cell lines. The ethanolic extract of the flowers was prepared in the present study. Phytochemical analysis of the plant extract revealed the presence of several phenolic compounds such as cinnamic acid and its derivatives (chlorogenic, p-coumaric, ferulic acids), protocatechuic acid, epicatechin and luteolin. This extract was tested against human breast (MDA-MB-231) and liver (HepG2) cancer cell lines to find out its antiproliferative activity. It was determined that the extract was effective against both cell lines with IC50 values of 2.37 ± 0.47 and 0.98 ± 0.01 µL/mL for MDA-MB-231 and HepG2, respectively. Particularly, the extract was found to be more effective in the liver cancer cell line than the breast cancer cell line. All these obtained findings led us to believe that this medicinal plant could be a promising antiproliferative agent candidate for the treatment of human liver and breast cancers.

Keywords

Antiproliferative activity, Cancer, Phenolic compounds, Spartium junceum

Supporting Institution

Süleyman Demirel University

Project Number

TSG-2021-8458

Thanks

SA is grateful to the Suleyman Demirel University Research Fund for their kind financial support with project number TSG-2021-8458.

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