Biosynthesis of ZnO nanoparticles using Laurus nobilis leaf extract and investigation of antiproliferative and antibacterial activity potential

Year 2023, Volume: 10 Issue: 3, 414 - 424, 27.08.2023

Firdevs Mert Sivri , Ebru Önem , Senem Akkoç , Cennet Çırrık , Aleyna Ezer

https://doi.org/10.21448/ijsm.1266244

Cited By: 2

Abstract

Nanotechnology has recently emerged as an essential field of study in modern materials science. The green synthesis of nanoparticles using plant extracts is of great interest because it is cost-effective, eco-friendly, and suitable for large-scale production. The study highlights the synthesis of ZnO nanoparticles (ZnO NPs) using Laurus nobilis (L. nobilis) leaf extract and their characterization and biological activities for potential applications in the biomedical field. ZnO NPs were synthesized using Laurus nobilis leaf extract. The synthesized ZnO NPs were characterized by UV-Vis spectroscopy, TEM, XRD, and FT-IR. According to TEM and XRD diffraction analysis, with a mean particle size of 16 ± 5 nm, it was found that the synthesized ZnO NPs contain a hexagonal wurtzite structure. ZnO NPs have antibacterial activity against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). The antiproliferative activity of ZnO NPs was tested against the human colon cancer cell line and mouse normal fibroblast cell line using MTT assay in vitro. The results show that the prepared nanoparticles had antiproliferative in screened incubation time and concentrations.

Keywords

Green synthesis, ZnO NPs, Laurus nobilis leaf, Antiproliferative activity, Antibacterial activity .

Supporting Institution

Suleyman Demirel University

Project Number

TSG-2021-8458 and TLP-2022-8777

Thanks

We would like to thank the Suleyman Demirel University Research Fund (TSG-2021-8458 and TLP-2022-8777) for financial support.

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