Examination of the chemical composition and anti-diabetic activities of the oils of Abelmoschus esculentus, Peganum harmala, and Aquilaria agallocha cultivated in Muğla

Year 2024, Volume: 11 Issue: 3, 584 - 591, 29.08.2024

Yunus Çetintaş , Ayşe Çetintaş Yusuf Sıcak , Mehmet Öztürk

https://doi.org/10.21448/ijsm.1413509

Abstract

In this study, the oils of Abelmoschus esculentus, Peganum harmala, and Aquilaria agallocha grown in different regions of Muğla, Türkiye were obtained using the cold pressing and maceration techniques. The oils were analyzed using Gas Chromatography-Mass Spectrometry (GC-MS) to determine their fatty acid compositions. Thirty-seven fatty acids were detected. Palmitic acid (C16:0), linoleic acid (C18:2), and oleic acid (C18:1 cis-9) were the major components in all oils. Additionally, the anti-diabetic activity of the oils was screened against α-amylase and α-glycosidase, which are the related enzymes to diabetes mellitus. Promising results regarding anti-diabetic activity for Aquilaria agallocha oils were obtained.

Keywords

Anti-diabetic activities, Fatty acid, Belmoschus esculentus, Peganum harmala, Aquilaria agallocha

References

• Alam, J., Mujahid, M., Rahman, M.A., Akhtar, J., Khalid, M., Jahan, Y., ..., & Iqbal, S.S. (2015). An insight of pharmacognostic study and phytopharmacology of Aquilaria agallocha. Journal of Applied Pharmaceutical Science, 5(8),173 181. https://doi.org/10.7324/JAPS.2015.50827
• Aleissa, M.S., Mohammed, A.Z., Alneghery, L.M., Hasnain, M.S., Almutairi, B., Ali, D., Alarifi, S., & Alkahtani, S. (2022). Comparative study of the anti-diabetic effect of mucilage and seed extract of Abelmoschus esculentus against streptozotocin-induced diabetes in rat model. Journal of King Saud University Science, 34(8), 102297. https://doi.org/10.1016/j.jksus.2022.102297
• AOCS (2007). Free Fatty Acids in Crude and Refined Fats and Oils, Revised 2017, Official Method Ca 5a-40.
• Baysal, A. 2011. Trans yağ asitleri ile insulin direnci ve diyabet etkileşimi [Interaction of trans fatty acids with insulin resistance and diabetes]. Beslenme ve Diyet Dergisi, 39(1-2), 5-8. https://doi.org/10.33076/2011.BDD.334
• Dubey, P., & Mishra, S. (2017). A review on: Diabetes and okra (Abelmoschus esculentus). Journal of Medicinal Plants Studies, 5(3), 23-26.
• Gazem, R.A.A., & Chandrashekariah, S.A. (2014). Omega fatty acids in health and disease: a review, Journal of Pharmacy Research, 8(8), 1027-44.
• Jarret, R.L., Wang, M.L., & Levy, I.J. (2011). Seed oil and fatty acid content in okra (Abelmoschus esculentus) and related species. Journal of Agricultural and Food Chemistry, 59(8), 4019-4024. https://doi.org/10.1021/jf104590u
• Jarret, R.L., Wang, M.L., & Levy, I.J. (2011). Seed oil and fatty acid content in okra (Abelmoschus esculentus) and related species. Journal of Agricultural and Food Chemistry, 59(8), 4019-4024. https://doi.org/10.1021/jf104590u
• Kaya, E., & Akbas, P. (2023). Determination of the antimicrobial, antioxidant activities and fatty acid composition of Peganum harmala Seed. Brazilian Archives of Biology and Technology, 66, e23220237. https://doi.org/10.1590/1678-4324-2023220237
• Kim, J.S., Kwon, C.S., & Son, K.H. (2000). Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Bioscience, Biotechnology and Biochemistry, 64(11),2458-2461. https://doi.org/10.1271/bbb.64.2458
• Kıvrak, I., Kivrak, S., & Karababa, E. (2020). Assessment of bioactive compounds and antioxidant activity of Turkey tail medicinal mushroom Trametes versicolor (Agaricomycetes). International Journal of Medicinal Mushrooms, 22(6), 559-571. https://doi.org/10.1615/IntJMedMushrooms.2020035027
• Komeili, G., Hashemi, M., & Bameri-Niafar, M. (2016). Evaluation of anti-diabetic and antihyperlipidemic effects of Peganum harmala seeds in diabetic rats. Cholesterol, Article ID 7389864. https://doi.org/10.1155/2016/7389864
• Lopez, S., Bermudez, B., Ortega, A., Varela, L.M., Pacheco, Y.M., Villar, J., Abia, R. & Muriana, F.J. (2011). Effects of meals rich in either monounsaturated or saturated fat on lipid concentrations and on insulin secretion and action in subjects with high fasting triglyceride concentrations. The American Journal of Clinical Nutrition, 93, 494‑499.
• Pranakhon, R., Pannangpetch, P., & Aromdee, C. (2011). Anti-hyperglycemic activity of agarwood leaf extracts in STZ-induced diabetic rats and glucose uptake enhancement activity in rat adipocytes. Songklanakarin Journal of Science and Technology, 33(4), 405-410.
• Quan, N.V., Xuan, T.D., Tran, H.D., Thuy, N.T.D., Trang, L.T., Huong, C.T., Andriana, Y., & Tuyen, P.T. (2019). Antioxidant, α-amylase and α-glucosidase inhibitory activities and potential constituents of Canarium tramdenum bark. Molecules, 24(3),605. https://doi.org/10.3390/molecules24030605
• Rajagopal, P.L., Premaletha, K., & Sreejith, K.R. (2016). Antidiabetic potential of the flowers of Aquilaria agallocha Roxb. World Wide Journal of Multidisciplinary Research and Development, 2(4), 22-24.
• Scrimgeour, C. (2005). Bailey's Industrial Oil and Fat Products, Sixth Edition, Six Volume Set, Chemistry of Fatty Acids, Edited by Fereidoon Shahidi. John Wiley and Sons. 1-5.
• Singh, A.B., Chaturvedi, J.P., Narender, T., & Srivastava, A.K. (2008). Preliminary studied on the hypoglycemic effect of Peganum harmala seeds ethanol extract on normal and streptozocine induced diabetic rats. Indian Journal of Clinical Biochemistry, 23(4), 391-393. https://doi.org/10.1007/s12291-008-0086-3