D Vitamini Eksikliği Olan Hastalarda Sistemik İmmün İnflamasyon İndeksinin Değişkenliği

Year 2022, Volume: 10 Issue: 3, 984 - 991, 14.11.2022

Banu Büyükaydın , Tahsin Karaaslan

https://doi.org/10.33715/inonusaglik.1158831

Abstract

Bu çalışmada, D vitamini eksikliği olan hastalarda inflamasyonun yeni bir belirteci olarak kabul edilen sistemik immün inflamasyon indeksinin (SII) değişkenliği araştırıldı. Ayaktan tedavi olan hastaların biyokimyasal ve tam kan sayımı verileri dijital verilerden retrospektif olarak taranıp kaydedildi. SII, her hasta için tam kan parametreleri (nötrofil x trombosit/lenfosit) ile hesaplandı. SII ve D vitamini varyasyonu arasındaki ilişki araştırıldı. Çalışmaya alınan 113 hastanın yaş ortalaması 38.58±12.37 yıl idi. Ortalama D vitamini, B12 ve folat düzeyleri sırasıyla 13.68±6.57 ng/ml, 309.54±110.73 pg/ml ve 7.13±2.77 ng/ml idi. Ortalama SII 434.39±156.72 idi. D vitamini 38 hastada (%33.6) 10 ng/mL'nin altında iken, 56 hastada (%49.5) 10-20 ng/mL arasında, 19 hastada (%16.8) 20 ng/mL ve üzerindeydi. B12 vitamini birincil grupta ikincil gruba göre anlamlı derecede düşüktü (p<0.05). SII ile D vitamin değerleri arasında herhangi bir anlamlı ilişki bulunmadı (p>0.05). D vitamini eksikliği en yaygın sağlık sorunlarından biridir, D vitamini eksikliği ve inflamasyon arasındaki olası ilişkiler halen araştırılmaktadır. Bu çalışmada D vitamini eksikliği olan hastalarda SII varyasyonunu araştırıldı ancak herhangi bir ilişki bulunmadı.

Keywords

Enflamasyon, Beslenme, Sistemik immün-enflamasyon indeksi, Vitamin B12, Vitamin D, 25-OH vitamin D

Supporting Institution

Yoktur

THE VARIATION OF THE SYSTEMIC IMMUNE-INFLAMMATION INDEX IN THE PATIENTS WITH VITAMIN D DEFICIENCY

Abstract

In this study, the variability of the systemic immune inflammation index (SII), which is accepted as a new marker of inflammation, was researched in patients with vitamin D deficiency. The biochemistry and hemogram results of outpatients were scanned and recorded retrospectively from digital data. SII was calculated with whole blood parameters (neutrophil x platelet/lymphocyte) for each patient. The relationship between SII and vitamin D variation was investigated. The mean age of 113 patients included in the study was 38.58±12.37 years. Mean levels of vitamin D, B12, and folate were 13.68±6.57 ng/ml, 309.54±110.73 pg/ml and 7.13±2.77 ng/ml, respectively. The mean SII was 434.39±156.72. While vitamin D was below 10 ng/mL in 38 patients (33.6%), it was between 10-20 ng/mL in 56 patients (49.5%) and 20 ng/mL and above in 19 patients (16.8%). Vitamin B12 was lower in the primary group than in the second group (p<0.05). No significant correlation was found between SII and vitamin D values (p>0.05). Vitamin D deficiency is one of the most common health problems, and possible relationships between vitamin D deficiency and inflammation are still under investigation. In this study, we researched the SII variation in patients with vitamin D deficiency, but no relationship was observed.

Keywords

Inflammation, Nutrition, Systemic immune-inflammation index, Vitamin B12, Vitamin D, 25-OH vitamin D

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