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Unusual finding on bone scintigraphy: Cerebral 99m-tc mdp involvement

Year 2024, , 96 - 98, 02.09.2024
https://doi.org/10.17944/interdiscip.1409955

Abstract

99mTc-MDP (99mTc-methylene diphosphonate) uptake in the brain parenchyma was observed in the scintigraphic imaging of a 56 years old male patient with renal cell carcinoma (RCC), who was referred to our clinic for metastasis screening due to widespread bone pain. Uptake of 99mTc-MDP in the brain parenchyma in bone scintigraphy is a rare finding. This case is presented to reveal the causes of cerebral 99mTc-MDP involvement.

References

  • Gnanasegaran G, Cook G, Adamson K, Fogelman I. Patterns. Variants, artifacts, and pitfalls in conventional radionuclide bone imaging and SPECT/CT. Semin Nucl Med. 2009;39(6):380-95. https://doi.org/10.1053/j.semnuclmed.2009.07.003
  • O'Connor MK, Brown ML, Hung JC, Hayostek RJ. The art of bone scintigraphy--technical aspects. J Nucl Med. 1991;32(12):2332-41.
  • Horger M, Bares R. The role of single-photon emission computed tomography/computed tomography in benign and malignant bone disease. Semin Nucl Med. 2006;36(4):286-94. https://doi.org/10.1053/j.semnuclmed.2006.05.001
  • Mohd Rohani MF, Zanial AZ, Suppiah S, et al. Bone single-photon emission computed tomography/computed tomography in cancer care in the past decade: a systematic review and meta-analysis as well as recommendations for further work. Nucl Med Commun. 2021;42(1):9-20. https://doi.org/10.1097/MNM.0000000000001306
  • Van den Wyngaert T, Strobel K, Kampen WU, et al; EANM Bone & Joint Committee and the Oncology Committee. The EANM practice guidelines for bone scintigraphy. Eur J Nucl Med Mol Imaging. 2016;43(9):1723-38. https://doi.org/10.1007/s00259-016-3415-4
  • O'Sullivan JM, Cook GJ. A review of the efficacy of bone scanning in prostate and breast cancer. Q J Nucl Med. 2002;46(2):152-9.
  • Love C, Din AS, Tomas MB, Kalapparambath TP, Palestro CJ. Radionuclide bone imaging: an illustrative review. Radiographics. 2003;23(2):341-58. https://doi.org/10.1148/rg.232025103
  • Nuclear Medicine in Clinical Diagnosis and Treatment, 3rd ed. AJNR Am J Neuroradiol. 2006;27(2):464–5.
  • Crawshaw JW, Allan R. Middle cerebral artery infarct demonstrated on bone scintigraphy. Eur J Nucl Med Mol Imaging. 2007;34(2):306. https://doi.org/10.1007/s00259-006-0181-8
  • Zuckier LS, Martineau P. Altered biodistribution of radiopharmaceuticals used in bone scintigraphy. Semin Nucl Med. 2015;45(1):81-96. https://doi.org/10.1053/j.semnuclmed.2014.07.007
  • Peller PJ, Ho VB, Kransdorf MJ. Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 1993;13(4):715-34. https://doi.org/10.1148/radiographics.13.4.8356264
Year 2024, , 96 - 98, 02.09.2024
https://doi.org/10.17944/interdiscip.1409955

Abstract

References

  • Gnanasegaran G, Cook G, Adamson K, Fogelman I. Patterns. Variants, artifacts, and pitfalls in conventional radionuclide bone imaging and SPECT/CT. Semin Nucl Med. 2009;39(6):380-95. https://doi.org/10.1053/j.semnuclmed.2009.07.003
  • O'Connor MK, Brown ML, Hung JC, Hayostek RJ. The art of bone scintigraphy--technical aspects. J Nucl Med. 1991;32(12):2332-41.
  • Horger M, Bares R. The role of single-photon emission computed tomography/computed tomography in benign and malignant bone disease. Semin Nucl Med. 2006;36(4):286-94. https://doi.org/10.1053/j.semnuclmed.2006.05.001
  • Mohd Rohani MF, Zanial AZ, Suppiah S, et al. Bone single-photon emission computed tomography/computed tomography in cancer care in the past decade: a systematic review and meta-analysis as well as recommendations for further work. Nucl Med Commun. 2021;42(1):9-20. https://doi.org/10.1097/MNM.0000000000001306
  • Van den Wyngaert T, Strobel K, Kampen WU, et al; EANM Bone & Joint Committee and the Oncology Committee. The EANM practice guidelines for bone scintigraphy. Eur J Nucl Med Mol Imaging. 2016;43(9):1723-38. https://doi.org/10.1007/s00259-016-3415-4
  • O'Sullivan JM, Cook GJ. A review of the efficacy of bone scanning in prostate and breast cancer. Q J Nucl Med. 2002;46(2):152-9.
  • Love C, Din AS, Tomas MB, Kalapparambath TP, Palestro CJ. Radionuclide bone imaging: an illustrative review. Radiographics. 2003;23(2):341-58. https://doi.org/10.1148/rg.232025103
  • Nuclear Medicine in Clinical Diagnosis and Treatment, 3rd ed. AJNR Am J Neuroradiol. 2006;27(2):464–5.
  • Crawshaw JW, Allan R. Middle cerebral artery infarct demonstrated on bone scintigraphy. Eur J Nucl Med Mol Imaging. 2007;34(2):306. https://doi.org/10.1007/s00259-006-0181-8
  • Zuckier LS, Martineau P. Altered biodistribution of radiopharmaceuticals used in bone scintigraphy. Semin Nucl Med. 2015;45(1):81-96. https://doi.org/10.1053/j.semnuclmed.2014.07.007
  • Peller PJ, Ho VB, Kransdorf MJ. Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 1993;13(4):715-34. https://doi.org/10.1148/radiographics.13.4.8356264
There are 11 citations in total.

Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section Case Reports
Authors

Edanur Ekinci 0000-0003-3850-5816

Ebuzer Kalender 0000-0001-8472-3174

Yusuf Burak Çayırlı 0000-0001-7563-3484

Publication Date September 2, 2024
Submission Date December 25, 2023
Acceptance Date May 4, 2024
Published in Issue Year 2024

Cite

Vancouver Ekinci E, Kalender E, Çayırlı YB. Unusual finding on bone scintigraphy: Cerebral 99m-tc mdp involvement. Interdiscip Med J. 2024;15(52):96-8.