A rare malignity observed in the appearance of angiomyolipoma; tubulocystic renal cell carcinoma after partial nephrectomy

Year 2023, Volume: 14 Issue: 50, 209 - 213, 30.12.2023

Eser Ördek , İbrahim Halil Albayrak , Muhammed Nur Karadeniz , Bülent Katı

https://doi.org/10.17944/interdiscip.1410378

Abstract

Cystic neoplasms of the kidney are quite rare. Because they contain various differential diagnoses and their radiological features are not specific, their diagnosis is very difficult except for histopathological data. Usually, they can be confused radiologically with benign cysts of the kidney or angiomyolipoma. Radical or partial nephrectomy is the most commonly preferred curative treatment method when it shows features like rapidly growing or malignancy. Histopathological examination is required for definitive diagnosis. In this article, we aimed to present a rare case of tubulocystic renal cell carcinoma after partial nephrectomy in our clinic, who was followed up in another center for years with the pre-diagnosis of angiomyolipoma, in the light of the literature.

Keywords

Renal Cell Carcinoma, Angiomyolipoma, Tubulocystic Renal Cell Carcinoma

References

• Srigley JR, Delahunt B, Eble JN, Egevad L, Epstein JI, Grignon D, et al. ISUP renal tumor panel: The international society of urological pathology (ISUP) Vancouver classification of renal neoplasia. Am J Surg Pathol. 2013;37:1469–89. https://doi.org/10.1097/PAS.0b013e318299f2d1
• Honda Y, Nakamura Y, Goto K, Terada H, Sentani K, Yasui W, et al. Tubulocystic renal cell carcinoma: a review of literature focused on radiological findings for differential diagnosis. Abdom Radiol 2018; 43: 1540–1545. https://doi.org/10.1007/s00261-018-1643-8
• Amin MB, MacLennan GT, Gupta R, Grignon D, Paraf F, Vieillefond A, et al. Tubulocystic carcinoma of the kidney: Clinicopathological analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. Am J Surg Pathol. 2009;33:384–92. https://doi.org/10.1097/PAS.0b013e3181872d3f
• Zhou M, Yang XJ, Lopez JI, Shah RB, Hes O, Shen SS, et al. Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: Implications for pathologic classification. Am J Surg Pathol. 2009;33:1840–9. https://doi.org/10.1097/PAS.0b013e3181be22d1
• Kakkar A, Sharma MC, Uppal M, Chumber S. Tubulocystic renal cell carcinoma: Report of a rare case. Can Urol Assoc J. 2015;9(9-10):E654-E657. https://doi.org/10.5489/cuaj.2935
• Srigley JR, Delahunt B. Uncommon and recently described renal carcinomas. Mod Pathol. 2009;22:S2–S23. https://doi.org/10.1038/modpathol.2009.70
• Kuroda N, Matsumoto H, Ohe C, Mikami S, Nagashima Y, Inoue K, et al. Review of tubulocystic carcinoma of the kidney with focus on clinical and pathobiological aspects. Pol J Pathol. 2013 Dec;64(4):233-7. https://doi.org/10.5114/pjp.2013.39329
• Nouhaud FX, Bernhard JC, Bigot P, Khene ZE, Audenet F, Lang H, et al. Contemporary assessment of the correlation between Bosniak classification and histological characteristics of surgically removed atypical renal cysts (UroCCR-12 study). World J Urol. 2018 Oct;36(10):1643-1649. https://doi.org/10.1007/s00345-018-2307-6
• Narayanasamy S, Krishna S, Prasad Shanbhogue AK, Flood TA, Sadoughi N, Sathiadoss P, et al. Contemporary update on imaging of cystic renal masses with histopathological correlation and emphasis on patient management. Clin Radiol. 2019 Feb;74(2):83-94. https://doi.org/10.1016/j.crad.2018.09.003
• Zhao M, Teng X, Ru G, Zhao Z, Hu Q, Han L, et al. Tubulocystic renal cell carcinoma with poorly differentiated foci is indicative of aggressive behavior: clinicopathologic study of two cases and review of the literature. Int J Clin Exp Pathol. 2015;8(9):11124-11131. Published 2015 Sep 1.
• Bhullar JS, Bindroo S, Varshney N, Mittal V. A new type of renal cancer—tubulocystic carcinoma of the kidney: a review of the literature. Int J Surg Pathol 2014; 22(4): 297–302. https://doi.org/10.15586/jkcvhl.2014.13
• Salvatori F, Macchini M, Misericordia M, Paci E, Giovagnoni A, Candelari R. A simple cyst is not always simply a cyst: A case of cystic recurrence after nephrectomy for tubulocystic renal cell carcinoma and literature review. Urologia Journal. 2020;87(3):119-124. https://doi.org/10.1177/0391560319870091
• Sangle NA, Mao R, Shetty S, Schiffman JD, Dechet C, Layfield L, et al. Novel molecular aberrations and pathologic findings in a tubulocystic variant of renal cell carcinoma. Indian J Pathol Microbiol. 2013;56:428–33
• Iakovleva G, Iakovlev V, Ordon M, Srigley J, Yousef GM. Tubulocystic carcinoma of kidney: a challenging diagnostic entity mimick-ing multicystic kidney and presenting with bone metastasis. Histopathology. 2015 May;66(6):892-894. https://doi.org/10.1111/his.12502