Clinical significance of mean platelet volume, platelet distribution width, and neutrophil-lymphocyte ratio in children with familial mediterranean fever

Year 2024, Volume: 15 Issue: 52, 54 - 59, 02.09.2024

Gül Trabzon , Müferet Ergüven , Didem Kızmaz İşançlı , Emine Olcay Yasa

https://doi.org/10.17944/interdiscip.1432324

Abstract

Objective: Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by recurrent fever and polyserositis. Studies conducted in recent years emphasize the importance of platelet parameters in chronic diseases. This study examined changes in attack and attack-free periods in children with FMF, focusing on Mean Platelet Volume (MPV), an indicator of disease severity.
Method: 150 FMF patients (90 girls, 60 boys) and 50 healthy individuals (29 men, 21 women) were included in the study. Data were analyzed according to colchicine treatment, attack, and attack-free periods. The severity of the disease was classified as mild, moderate, and severe.
Results: MPV levels of patients with FMF were higher than the healthy group. In particular, MPV levels decreased significantly during attacks, with a more pronounced decrease in severe cases.
Conclusion: As a result, MPV measurement is a cost-effective and rapid method that can support the evaluation of disease severity and attack periods in FMF patients.

Keywords

Familial Mediterranean Fever, MPV, Neutrophil/Lymphocyte Ratio, M694V, PDW

Ethical Statement

The work was evaluated and approved by the Ethnic Committee of the University of İstanbul Medeniyet. All procedures performed in studies involving human participants were by the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards

Supporting Institution

The study received no financial support or funding from any pharmaceutical company, medical device manufacturer, or other commercial entity that could benefit from this research’s results. All data analysis and interpretations were conducted independently by the authors.

Thanks

All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication. I thank all the authors for their study.

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