FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES

Orkide Kutlu; Caecilie Crawley Larsen; Solomon Maximo Greenberg; Alfonso Massimiliano Ferrara; Samuel Refetoff; Ferda Sevimli Burnık; Cevdet Duran

doi:10.18017/iuitfd.01011

FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES

Year 2016, Volume: 79 Issue: 1, 51 - 53, 19.04.2016

Orkide Kutlu , Caecilie Crawley Larsen Solomon Maximo Greenberg Alfonso Massimiliano Ferrara Samuel Refetoff Ferda Sevimli Burnık Cevdet Duran

https://doi.org/10.18017/iuitfd.01011

Abstract

The prevalence of autoimmune thyroid disease (AITD) has progressively increased. Circulating autoantibodies associated with AITD may affect the result of laboratory analyses and cause incorrect conclusions in the assessment of thyroid hormone status. In this report, we present a patient with Hashimoto’s thyroiditis with high thyrotrophin and free thyroxine (T4) and triiodothyronine (T₃) levels due to the presence of auto-antibodies to iodothyronines. Free T₄ and free T₃ levels measured by direct immunometric assays method were high, while those estimated by measurement of the serum T₄-binding capacity were low. L-thyroxine replacement therapy was started. In patients with discrepant laboratory results, interference from autoantibodies should be considered.

Key words: Thyroxine auto-antibody, hypothyroidism, false high free thyroxine, triiodothyronine levels,

Keywords

Thyroxine auto-antibody, hypothyroidism, false high free thyroxine, triiodothyronine levels

İYODOTİRONİN OTOANTİKORLARI SEBEBİ İLE YALANCI YÜKSEK TİROKSİN VE TRİİYODOTİRONİN DÜZEYLERİ

Year 2016, Volume: 79 Issue: 1, 51 - 53, 19.04.2016

Orkide Kutlu , Caecilie Crawley Larsen Solomon Maximo Greenberg Alfonso Massimiliano Ferrara Samuel Refetoff Ferda Sevimli Burnık Cevdet Duran

https://doi.org/10.18017/iuitfd.01011

Abstract

Otoimmun tiroid hastalığı
prevalansı giderek artmaktadır. Otoimmun tiroid hastalığı ile ilişkili
otoantikorlar laboratuvar sonuçlarını etkileyebilmekte ve tiroid hormon
durumunu değerlendirmede yanılmalara sebep olabilmektedir. Burada iyodotironin
otoantikorları sebebi ile serbest tiroksin (T₄), triiyodotironin (T₃)
ve TSH düzeyleri yüksek bir hasta sunduk. Direkt immunometrik yöntemlerle
ölçülen free T₄ ve T₃ düzeyleri yüksek olmasına
rağmen, serum T₄ bağlama kapasitesi ölçümü ile tahmin
edilen değerler düşük olduğundan hastaya L-tiroksin replasman tedavisi
başlanmıştır. Bu çalışmada; nadir karşılaşılan free T₄, T₃ ve TSH düzeylerinde
tutarsızlık/uyumsuzluk bulunan hastalarda ayırıcı tanı olarak iyodotironin
otoantikorlarına bağlı otoimmun tiroid hastalığı görülebileceği vurgulanmıştır.

Anahtar kelimeler: Tiroksin otoantikoru, hipotiroidi, yalancı
yüksek serbest tiroksin, tiriiodotironin düzeyleri, otoimmun tiroidit,

Keywords

Tiroksin otoantikoru, hipotiroidi, yalancı yüksek serbest tiroksin, tiriiodotironin düzeyleri, otoimmun tiroidit

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Details

Subjects	Health Care Administration
Journal Section	Case Reports
Authors	Orkide Kutlu Caecilie Crawley Larsen This is me Solomon Maximo Greenberg This is me Alfonso Massimiliano Ferrara This is me Samuel Refetoff This is me Ferda Sevimli Burnık This is me Cevdet Duran
Publication Date	April 19, 2016
Submission Date	January 8, 2016
Published in Issue	Year 2016 Volume: 79 Issue: 1

Cite

APA	Kutlu, O., Larsen, C. C., Greenberg, S. M., Ferrara, A. M., et al. (2016). FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES. Journal of Istanbul Faculty of Medicine, 79(1), 51-53. https://doi.org/10.18017/iuitfd.01011
AMA	Kutlu O, Larsen CC, Greenberg SM, Ferrara AM, Refetoff S, Sevimli Burnık F, Duran C. FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES. İst Tıp Fak Derg. April 2016;79(1):51-53. doi:10.18017/iuitfd.01011
Chicago	Kutlu, Orkide, Caecilie Crawley Larsen, Solomon Maximo Greenberg, Alfonso Massimiliano Ferrara, Samuel Refetoff, Ferda Sevimli Burnık, and Cevdet Duran. “FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES”. Journal of Istanbul Faculty of Medicine 79, no. 1 (April 2016): 51-53. https://doi.org/10.18017/iuitfd.01011.
EndNote	Kutlu O, Larsen CC, Greenberg SM, Ferrara AM, Refetoff S, Sevimli Burnık F, Duran C (April 1, 2016) FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES. Journal of Istanbul Faculty of Medicine 79 1 51–53.
IEEE	O. Kutlu, C. C. Larsen, S. M. Greenberg, A. M. Ferrara, S. Refetoff, F. Sevimli Burnık, and C. Duran, “FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES”, İst Tıp Fak Derg, vol. 79, no. 1, pp. 51–53, 2016, doi: 10.18017/iuitfd.01011.
ISNAD	Kutlu, Orkide et al. “FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES”. Journal of Istanbul Faculty of Medicine 79/1 (April 2016), 51-53. https://doi.org/10.18017/iuitfd.01011.
JAMA	Kutlu O, Larsen CC, Greenberg SM, Ferrara AM, Refetoff S, Sevimli Burnık F, Duran C. FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES. İst Tıp Fak Derg. 2016;79:51–53.
MLA	Kutlu, Orkide et al. “FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES”. Journal of Istanbul Faculty of Medicine, vol. 79, no. 1, 2016, pp. 51-53, doi:10.18017/iuitfd.01011.
Vancouver	Kutlu O, Larsen CC, Greenberg SM, Ferrara AM, Refetoff S, Sevimli Burnık F, Duran C. FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES. İst Tıp Fak Derg. 2016;79(1):51-3.