MEDICAL TREATMENT OF LEIOMYOMAS

Year 2017, Volume: 80 Issue: 4, 153 - 161, 20.12.2017

Funda Güngör Uğurlucan , Ömer Demir Cenk Yaşa Özlem Dural

https://doi.org/10.18017/iuitfd.382765

Abstract

Leiomyomlar,
reprodüktif çağda en sık görülen jinekolojik tümörlerdir. Leiomyomlar çoğu
kadında bulunmakla beraber, bazı kadınlarda semptomatik hale gelmektedir.
Genetik veya hormonal kökenli olabilirler. Leiomyomların üzerinde östrojen ve
progesteron reseptörleri olması, onları hormona duyarlı hale getirmektedir. Leiomyomların
ana tedavisi cerrahi olmakla beraber, cerrahi istemeyen veya fertilitesini
korumak isteyen kadınlarda medikal tedaviler gündeme gelmektedir. Medikal
tedavilerin çıkış noktası, leiomyomların hormona duyarlı olmasıdır. Medikal
tedavi seçenekleri arasında gonadotropin-releasing-3 hormon analogları ve
antagonistleri, aromataz inhibitörleri ve selektif progesteron reseptör
modülatörleri yer almaktadır. Bu tedaviler kanama kontrolünün yanında leiomyom
volümünde de küçülme sağlamaktadır. Bu derlemede bu tedavi yöntemlerine
değinilecektir.

Keywords

Leiomyoma, abnormal uterine bleeding, selective progesterone receptor modulators, ulipristal acetate, anemia

LEİOMYOMLARIN MEDİKAL TEDAVİSİ

Abstract

Leiomyomlar,
reprodüktif çağda en sık görülen jinekolojik tümörlerdir. Leiomyomlar çoğu
kadında bulunmakla beraber, bazı kadınlarda semptomatik hale gelmektedir.
Genetik veya hormonal kökenli olabilirler. Leiomyomların üzerinde östrojen ve
progesteron reseptörleri olması, onları hormona duyarlı hale getirmektedir. Leiomyomların
ana tedavisi cerrahi olmakla beraber, cerrahi istemeyen veya fertilitesini
korumak isteyen kadınlarda medikal tedaviler gündeme gelmektedir. Medikal
tedavilerin çıkış noktası, leiomyomların hormona duyarlı olmasıdır. Medikal
tedavi seçenekleri arasında gonadotropin-releasing-3 hormon analogları ve
antagonistleri, aromataz inhibitörleri ve selektif progesteron reseptör
modülatörleri yer almaktadır. Bu tedaviler kanama kontrolünün yanında leiomyom
volümünde de küçülme sağlamaktadır. Bu derlemede bu tedavi yöntemlerine
değinilecektir.

Keywords

Leiomyom, anormal uterin kanama, selektif progesteron reseptör modülatörleri, ulipristal asetat, anemi

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