GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME

Year 2019, Volume: 82 Issue: 3, 162 - 163, 16.07.2019

Bahadır Turan Mehmet Akif Akıncı İbrahim Selçuk Esin , Onur Burak Dursun

https://doi.org/10.26650/IUITFD.2019.0011

Abstract

Triple X syndrome (47, XXX) is a numerical chromosomal alteration that affects 1/1.000 females, in which the individual is born with an extra X chromosome. Trisomy X is a relatively common but under- recognized chromosomal disorder associated with characteristic cognitive and behavioural features of varying severity. We report a 16-year old patient with Triple X syndrome and resistant schizophrenia. It is remarkable that genetic syndromes may be associated with resistance to treatment of psychiatric problems. Therefore in cases with treatment resistance, the genetic analysis should absolutely be examined. 

Keywords

Schizophrenia, treatment resistance, Triple X syndrome

ŞİZOFRENİDE TEDAVİYE DİRENÇ NEDENİ OLARAK GENETİK SENDROMLAR: TRİPLE X SENDROMLU BİR OLGU

Abstract

Amaç: Triple X sendromu (47, XXX), kadınlarda ekstra bir X kromozomunun varlığı ile karakterize, 1/1.000 kişide bir görülen bir sendromdur. Trizomi X, değişken şiddette bilişsel ve davranışsal özelliklerle karakterize bir kromozomal hastalıktır. Bu olgu sunumunda; Triple X sendromlu ve dirençli şizofreni tanısı alan 16 yaşında bir vaka sunuyoruz. Genetik sendromların psikiyatrik problemlerin tedavisinde tedaviye dirençle ilişkili olabileceği ve bu nedenle tedaviye dirençli olgularda genetik analizlerin mutlaka yapılması gerektiği göz önünde bulundurulmalıdır. 

Keywords

Şizofreni, tedaviye direnç, Triple X sendrom

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