BEHÇET HASTALIĞI OLAN ÇOCUKLARIN İŞİTME DURUMU: PROSPEKTİF BİR ÖN ÇALIŞMA

Year 2021, Volume: 84 Issue: 4, 537 - 542, 01.10.2021

Nuray Aktay Ayaz , Gonca Keskindemirci , Zehra Cinar Özgür Yiğit , Cigdem Kalaycik Ertugay , Mustafa Çakan , Serife Gul Karadag Esat Alkaya

https://doi.org/10.26650/IUITFD.2021.837691

Abstract

Amaç: Behçet Hastalığı (BH) olan çocukların işitme durumunu araştırmayı amaçladık. Gereç ve Yöntem: Bu çalışma prospektif, kesitsel, kontrollü bir çalışmadır. On beş BH olan ve 13 sağlıklı çocuğa yüksek frekansları içeren saf ses odyometrisi ve distorsiyon ürünü otoakustik emisyon (DPOAE) uygulanmıştır. Bulgular: Her iki grup da normal işitme seviyelerine sahip olmasına rağmen, çalışma grubunun saf ses ortalaması sağlıklı kontrollerden daha yüksekti. 500 Hz ve 4000 Hz’de işitme eşikleri BH’li çocuklarda istatistiksel olarak anlamlı derecede daha yüksekti. 1000 Hz ve 4000 Hz’de DPOAE seviyelerinde önemli fark vardı. BH olan çocuklar bu frekanslarda daha düşük seviyelere sahipti. Sonuç: İki grup arasındaki saf ses odyometrisindeki istatistiksel farklılıklara rağmen, delta yaklaşık 5 dB idi ve bunun klinik önemi olmayabilir. Ancak bu çocuklarda yapılan ilk çalışmadır ve daha fazla çalışmaya ihtiyaç vardır.

Keywords

işitme değerlendirmesi, Behçet hastalığı, otoakustik emisyon, çocuklar

HEARING STATUS OF CHILDREN WITH BEHÇET’S DISEASE: A PROSPECTIVE PRELIMINARY STUDY

Abstract

Objective: We aimed to evaluate the hearing status of children with Behçet’s Disease (BD). Materials and Method: It is a prospective, cross-sectional, controlled study. Pure-tone audiometry including high-frequencies and distortion product otoacoustic emission (DPOAE) were performed in 15 children with BD and 13 healthy controls. Results: Although both groups had normal hearing levels, the pure tone average of the study group was higher than the healthy controls. Hearing thresholds at 500 Hz and 4000 Hz were statistically significantly higher in children with BD. There was a significant difference in DPOAE levels at 1000 Hz and 4000 Hz. Children with BD had lower levels at these frequencies. Conclusion: In spite of the statistical differences in pure tone audiometry between the two groups, the delta was about 5 dB, which might not have clinical importance. However, this is the first study in children, and further studies are required.

Keywords

Hearing evaluation, Behçet’s disease, otoacoustic emission, children

References

• 1. Behcet H. Uber rezideivierende, aphtose, durch ein virüs veursachte Geschure am Mund, Am Auge und an den Genitalien. Dermatol Wachenschr 1937;105:152-7.
• 2. Karincaoglu Y, Borlu M, Toker SC, Akman A, Onder M, Gunasti S, et al. Demographic and clinical properties of juvenile-onset Behçet’s disease: A controlled multicenter study. J Am Acad Dermatol 2008;58(4):579-84. [CrossRef]
• 3. Sungur GK, Hazirolan D, Yalvac I, Ozer PA, Yuksel D, Vural ET, et al. Clinical and demographic evaluation of Behcet disease among different paediatric age groups. Br J Ophthalmol 2009;93(1):83-7. [CrossRef]
• 4. Sonbay ND, Saka C, Tatlican S, Vuralkan E, Aygener N, Eren C, et al. Audiological evaluation in patients with Behçet’s disease. J Laryngol Otol 2014;128(8):694-7. [CrossRef]
• 5. Soylu L, Aydoğan B, Soylu M, Ozsahinoğlu C. Hearing loss in Behçet’s disease. Ann Otol Rhinol Laryngol 1995;104(11):864-7. [CrossRef]
• 6. Kemal O, Anadolu Y, Boyvat A, Tatarağası A. Behçet disease as a cause of hearing loss: A prospective, placebo-controlled study of 29 patients. Ear Nose Throat J 2013;92(3):112-20. [CrossRef]
• 7. Süslü AE, Polat M, Köybaşi S, Biçer YO, Funda YO, Parlak AH. Inner ear involvement in Behçet’s disease. Auris Nasus Larynx 2010;37(3):286-90. [CrossRef]
• 8. Marsili M, Marzetti V, Lucantoni M, Lapergola G, Guttarno M, Chiarelli F, et al. Autoimmune sensorineural hearing loss as presenting manifestation of paediatric Behçet disease responding to adalimumab: a case report. Ital J Pediatr 2016;42(1):81. [CrossRef]
• 9. International Study Group for Behcet’s Disease. Criteria for diagnosis of Behcet’s disease. Lancet 1990;335(8697):1078- 80. [CrossRef]
• 10. Azizlerli G, Köse AA, Sarica R,Gül A, Tutkun IT, Kulaç M, et al. Prevalence of Behçet’s disease in Istanbul, Turkey. Int J Dermatol 2003;42(10):803-6. [CrossRef]
• 11. Gurler A, Boyvat A, Tursen U. Clinical manifestations of Behcet’s disease: an analysis of 2147 patients. Yonsei Med J 1997;38(6):423-7. [CrossRef]
• 12. Krause I, Uziel Y, Guedj D, Mukamel M, Harel L, Molad Y, et al. Childhood Behcet’s disease: clinical features and comparison with adult-onset disease. Rheumatology (Oxford) 1999;38(5):457-62. [CrossRef]
• 13. Sarica R, Azizlerli G, Köse A, Dişçi R, Ovül C, Kural Z. Juvenile Behcet’s disease among 1784 Turkish Behcet’s patients. Int J Dermatol 1996;35(2):109-11. [CrossRef]
• 14. Uziel Y, Brik R, Padeh S, Barash J, Mukamel M, Harel L, et al. Juvenile Behcet’s disease in Israel: the pediatric rheumatology study group of Israel. Clin Exp Rheumatol 1998;16(4):502-5.
• 15. AK E, Harputluoglu U, Oghan F, Baykal B. Behçet’s disease and hearing loss. Auris Nasus Larynx 2004;31(1):29-33. [CrossRef]
• 16. Bakhshaee M, Ghasemi MM, Hatef MR, Talebmehr M, Shakeri MT. Hearing loss in Behçet syndrome. Otolaryngol Head Neck Surg 2007;137(3):439-42. [CrossRef]
• 17. Dagli M, Eryilmaz A, Tanrikulu S, Aydın A, Gönül M, Ulker G, et al. Evaluation of cochlear involvement by distortion product otoacoustic emission in Behçet’s disease. Auris Nasus Larynx 2008;35(3):333-7. [CrossRef]
• 18. Keskindemirci G, Ayaz NA, Batıoğlu-Karaaltın A, Dönmez Z, Özgür Y, Aydoğan G, et al. Cochlear functions in children with familial Mediterranean fever: any role of the severity of the disease. Int J Pediatr Otorhinolaryngol 2015;79(9):1566- 70. [CrossRef]