PANCREATITIS IN GALLSTONE PATIENTS: IS THERE ANY LINK BETWEEN DIET AND DISEASE?

Year 2023, Volume: 86 Issue: 3, 192 - 197, 26.10.2023

Selim Doğan , Mert Mahsuni Sevinç , Ufuk Oguz İdiz , İshak Yıldız , Cemile İdiz

https://doi.org/10.26650/IUITFD.1293996

Abstract

Objective: Acute pancreatitis is most often caused by gallstones. There is no clear relationship between diet and gallstone pancreatitis. The purpose of this research was to examine dietary differences in pancreatitis patients with gallstones.
Material and Method: Patients with acute biliary pancreatitis and patients with gallstones without pancreatitis were included in this prospective case-control study. Groups were set to be similar in case numbers, age, gender, and gallbladder stone size. A threeday food consumption questionnaire and a food consumption frequency questionnaire were applied to all volunteers. The BeBis 8 Full version program was used to evaluate body mass index, alcohol and cigarette consumption status, daily physical activity status, eating frequency, and food consumption status.
Result: A total of 120 patients, including 60 patients who developed pancreatitis due to gallstones, and 60 patients who only had gallstones were included in the study. Among the demographic data, monthly income was statistically higher in pancreatitis. In addition, it was found that the daily milk-yoghurt, red meat, chicken, salami-sausage, egg, rice-pasta, protein, fat, and cholesterol intakes of patients with pancreatitis were significantly higher. In the multivariate logistic regression analysis, it was determined that the increase in daily milk-yoghurt, egg, rice-pasta and protein intake were independent risk factors.
Conclusion: Reducing the consumption of red meat, eggs, fat, cholesterol, milk-yoghurt, rice and pasta, salami and sausage in people with gallstones may reduce the incidence of acute pancreatitis in these individuals.

Keywords

Gallstone, Pancreatitis, Diet, Red meat, Egg

SAFRA TAŞI HASTALARINDA PANKREATİT: DİYET İLE HASTALIK ARASINDA BİR BAĞLANTI VAR MI?

Abstract

Amaç: Akut pankreatit genellikle safra taşlarından kaynaklanır. Diyet ile safra taşı pankreatit arasında net bir ilişki bulunmamaktadır. Bu araştırmanın amacı, safra taşı olan pankreatit hastalarında beslenme farklılıklarını incelemektir.
Gereç ve Yöntem: Bu prospektif vaka-kontrol çalışmasına akut biliyer pankreatiti olan hastalar ve pankreatit gelişmemiş safra taşı olan hastalar dahil edilmiştir. Gruplar, vaka sayıları, yaş, cinsiyet ve safra kesesi taşı büyüklüğü açısından benzer olarak belirlendi. Tüm gönüllülere üç günlük besin tüketim formu ve besin tüketim sıklığı formu uygulandı. Vücut kütle indeksi, alkol ve sigara tüketimi durumu, günlük fiziksel aktivite durumu, yeme sıklığı ve besin tüketim durumunu değerlendirmek için BeBis 8 Full versiyon programı kullanıldı.
Bulgular: Çalışmaya, safra taşları nedeniyle pankreatit gelişen 60 hasta ve pankreatit gelişmemiş safra taşı olan 60 hasta olmak üzere toplam 120 hasta dahil edildi. Demografik veriler arasında aylık gelir pankreatit gelişenlerde istatistiksel olarak daha yüksek bulundu. Ayrıca, pankreatitli hastaların günlük süt-yoğurt, kırmızı et, tavuk, salam-sosis, yumurta, pirinç-makarna, protein, yağ, kolesterol alımlarının anlamlı olarak daha yüksek olduğu tespit edildi. Çok değişkenli lojistik regresyon analizinde, günlük süt-yoğurt, yumurta, pirinç-makarna ve protein alımındaki artışın bağımsız risk faktörleri olduğu belirlendi.
Sonuç: Safra taşı olan bireylerde kırmızı et, yumurta, yağ, kolesterol, süt-yoğurt, pirinç ve makarna, salam ve sosis tüketiminin azaltılması, akut pankreatit insidansını bu kişilerde azaltabilir. urta, yağ, kolesterol, süt-yoğurt, pirinç ve makarna, salam ve sosis tüketiminin azaltılması, akut pankreatit insidansını bu kişilerde azaltabilir.

Keywords

Safra taşı, Pankreatit, Diyet, Kırmızı et, Yumurta

Supporting Institution

Yok

Thanks

Yok

References

• 1. Toouli J, Brooke-Smith M, Bassi C, Carr-Locke D, Telford J, Freeny P, et al. Guidelines for the management of acute pancreatitis. J Gastroenterol Hepatol 2002;17 Suppl:S15-39. [CrossRef] google scholar
• 2. Wang GJ, Gao CF, Wei D, Wang C, Ding SQ. Acute pancreatitis: etiology and common pathogenesis. World J Gastroenterol 2009;15(12):1427-30. [CrossRef] google scholar
• 3. Mendez-Sânchez N, Chavez-Tapia NC, Motola-Kuba D, Sanchez-Lara K, Ponciano-Rodrîguez G, Baptista H, et al. Metabolic syndrome as a risk factor for gallstone disease. World J Gastroenterol 2005;11(11):1653-7. [CrossRef] google scholar
• 4. Yoo EH, Lee SY. The prevalence and risk factors for gallstone disease. Clin Chem Lab Med 2009;47(7):795-807. [CrossRef] google scholar
• 5. Sarles H. An international survey on nutrition and pancreatitis. Digestion 1973;9(5):389-403. [CrossRef] google scholar
• 6. Wilson JS, Bernstein L, McDonald C, Tait A, McNeil D, Pirola, RC. Diet and drinking habits in relation to the development of alcoholic pancreatitis. Gut 1985;26(9):882-7. [CrossRef] google scholar
• 7. Schmidt DN. Apparent risk factors for chronic and acute pancreatitis in Stockholm county. Spirits but not wine and beer. Int J Pancreatol 1991;8(1):45-50. [CrossRef] google scholar
• 8. Niederau M, Niederau C, Strohmeyer G. Epidemiology of acute pancreatitis: Mortality data and correlation to consumption of alcohol and dietary factors. Digestion 1988;40(2):104-5. google scholar
• 9. Morton C, Klatsky AL, Udaltsova N. Smoking, coffee, and pancreatitis. Am J Gastroenterol 2004;99(4):731-8. [CrossRef] google scholar
• 10. Segal I, Charalambides D, Becker P, Ally R. Case control study of environmental factors in the etiology of the first attack of acute pancreatitis: A pilot study. International Journal of Pancreatology 2000;28(3):169-73. [CrossRef] google scholar
• 11. Mitta N, Barreto SG, Rodrigues J. Dietary risk factors for acute pancreatitis: A case-control study. Surgical Chronicles 2011;16(3):186-7. google scholar
• 12. Gao YJ, Li YQ, Wang Q, Li SL, Li GQ, Ma J, et al. Analysis of clinical features of acute pancreatitis in Shandong Province, China. J Gastroenterol Hepatol 2007;22(3):340-4. [CrossRef] google scholar
• 13. Matteo A, Sarles H. Is food allergy a cause of acute pancreatitis? Pancreas 1990;5(2):234-7. [CrossRef] google scholar
• 14. Idiz C, Cakir C. The Effect of Diet On Gallstones Formation in Turkish Patients: A Case-Control Study. Euras J Fam Med 2020;9(3):147-53. [CrossRef] google scholar
• 15. Jessri M, Rashidkhani B. Dietary patterns and risk of gallbladder disease: a hospital-based case-control study in adult women. J Health Popul Nutr 2015;33(1):39-49. google scholar
• 16. Worthington HV, Hunt LP, McCloy RF, Ubbink JB, Braganza JM. Dietary antioxidant lack, impaired he- patic glutathione reserve, and cholesterol gallstones. Clin Chim Acta 2004;349(1-2):157-65. [CrossRef] google scholar
• 17. Kritchevsky D, Klurfeld DM. Influence of vegetable protein on gallstone formation in hamsters. Am J Clin Nutr 1979;32(11):2174-6. [CrossRef] google scholar
• 18. Kritchevsky D, Klurfeld DM. Gallstone formation in hamsters: effect of varying animal and vegetable protein levels. Am J Clin Nutr 1983;37(5):802-4. [CrossRef] google scholar
• 19. Everson GT, McKinley C, Kern F Jr. Mechanisms of gallstone formation in women. Effects of exogenous estrogen (Premarin) and dietary cholesterol on hepatic lipid metabolism. J Clin Invest 1991;87(1):237-46. [CrossRef] google scholar
• 20. Misciagna G, Centonze S, Leoci C, Guerra V, Cis- ternino AM, Ceo R et al. Diet, physical activity, and gallstones—a population-based, case-control study in southern Italy. Am J Clin Nutr 1999;69(1):120-6. [CrossRef] google scholar
• 21. Leung PS, Chan YC. Role of oxidative stress in pancreatic inflammation. Antioxid Redox Signal 2009;11(1):135-65. [CrossRef] google scholar
• 22. Dugum M, Gougol A, Paragomi P, Gao X, Matta B, Yazici C, et al. Association of Dietary Habits with Severity of Acute Pancreatitis. Curr Dev Nutr 2018;2(12):nzy075. [CrossRef] google scholar
• 23. Setiawan VW, Pandol SJ, Porcel J, Wei PC, Wilkens LR, Le Marchand L, et al. Dietary Factors Reduce Risk of Acute Pancreatitis in a Large Multiethnic Cohort. Clin Gastroenterol Hepatol 2017;15(2):257-65.e3. [CrossRef] google scholar
• 24. Yang H, Wang L, Shi YH, Sui GT, Wu YF, Lu XQ, et al. Risk factors of acute pancreatitis in the elderly Chinese population: a population-based cross-sectional study. J Dig Dis 2014;15(9):501-7. [CrossRef] google scholar
• 25. Prizment AE, Jensen EH, Hopper AM, Virnig BA, Anderson KE. Risk factors for pancreatitis in older women: the Iowa Women’s Health Study. Ann Epidemiol 2015;25(7):544-8. [CrossRef] google scholar
• 26. Thomas T, Mah L, Barreto SG. Systematic review of diet in the pathogenesis of acute pancreatitis: a tale of too much or too little? Saudi J Gastroenterol 2012;18(5):310-5. [CrossRef] google scholar
• 27. Mendez-Sânchez N, Zamora-Valdes D, Châvez-Tapia NC, Uribe M. Role of diet in cholesterol gallstone formation. Clin Chim Acta 2007;376(1-2):1-8. [CrossRef] google scholar
• 28. Cuevas A, Miquel JF, Reyes MS, Zanlungo S, Nervi F. Diet as a risk factor for cholesterol gallstone disease. J Am Coll Nutr 2004;23(3):187-96. [CrossRef] google scholar
• 29. Oskarsson V, Orsini N, Sadr-Azodi O, Wolk A. Fish consumption and risk of non-gallstone-related acute pancreatitis: a prospective cohort study. Am J Clin Nutr 2015;101(1):72-8. [CrossRef] google scholar
• 30. Lindkvist B, Appelros S, Manjer J, Berglund G, Borgstrom A. A prospective cohort study of smoking in acute pancreatitis. Pancreatology 2008;8(1):63-70. [CrossRef] google scholar
• 31. Sadr-Azodi O, Andren-Sandberg Â, Orsini N, Wolk A. Cigarette smoking, smoking cessation and acute pancreatitis: a prospective population-based study. Gut 2012;61(2):262-7. [CrossRef] google scholar