Lökositoklastik Vaskülit: Beş Farklı Etyolojik Tanılı Hastanın Değerlendirilmesi

Year 2024, Volume: 3 Issue: 4, 180 - 185, 20.12.2024

Tuba Demirci Yıldırım

https://doi.org/10.57221/izmirtip.1512507

Abstract

Amaç: Lökositoklastik vaskülit (LSV), histopatolojik olarak dermal kapiller ve venüllerin immün kompleks aracılı vasküliti ile karakterize küçük damar vaskülitidir. Lökositoklastik vaskülit birçok hastalığın ilk bulgusu olarak karşımıza çıkabilir. Cilde sınırlı vaskülit olarak tek atakla sonlanabileceği gibi, lenfoproliferatif hastalıklar, inflamatuvar bağırsak hastalıkları gibi ciddi hastalıklardan da kaynaklanabilir. Vakalarımız bu çeşitliliğe dikkat çekerek, LSV’ nin etyolojisinin araştırılmasının önemini vurgulamaktadır.
Olgular: Kliniğimizde son iki yılda lökositoklastik vaskülit ön tanısı ile yatırılmış beş farklı olgunun tanısal süreçleri ve tedavileri tartışılmıştır. Cilt bulguları aynı olan beş olgunun tanıları Hodgkin Lenfoma, Sistemik Lupus Eritematozus (SLE), Crohn hastalığı, idiyopatik kutanöz küçük damar vasküliti ve İnsan İmmun Yetmezlik Virusu hastalığı ve Sifiliz birlikteliği olarak farklılık göstermiştir.
Sonuç: Vakalarımızın benzer fizik muayene bulguları ile gelerek farklı tanı ve tedaviler alması, lökositoklastik vaskülitin tanısal yaklaşımının ve tedavisinin multidisipliner bir yaklaşım gerektirdiğini göstermiştir.

Keywords

Lökositoklastik vaskülit, ANCA ilişkili vaskülit, lenfoproliferatif hastalıklar

Leukocytoclastic Vasculitis: Evaluation of Five Patients with Different Etiological Diagnoses

Abstract

Objective: Leukocytoclastic vasculitis (LSV) is a type of small vessel vasculitis characterized by immune complex-mediated inflammation of the small blood vessels in the skin. LSV can be the initial symptom of various underlying diseases. It may be a one-time occurrence, affecting only the skin, or it can be linked to more severe conditions such as lymphoproliferative diseases and inflammatory bowel diseases. Our cases highlight this range of associations and underscore the importance of investigating the underlying cause of LSV.
Cases: We discuss the diagnostic processes and treatments of five cases hospitalized with the preliminary diagnosis of leukocytoclastic vasculitis in our clinic in the last two years. The diagnoses of five cases with the same skin findings varied, including Hodgkin Lymphoma, Systemic Lupus Erythematosus (SLE), Crohn's disease, idiopathic cutaneous small vessel vasculitis, and coexistence of Human Immunodeficiency Virus disease and Syphilis.
Conclusion: Our cases presented similar physical examination findings yet received different diagnoses and treatments, illustrating the need for a multidisciplinary approach to diagnosing and treating leukocytoclastic vasculitis.

Keywords

Leukocytoclastic vasculitis, ANCA-associated vasculitis, lymphoproliferative diseases

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