Abstract
İştah ve enerji dengesi uzun yıllardır araştırmalarla aydınlatılmaya çalışılmaktadır. Beyindeki melanokortin sistemi bu dengenin korunmasında önemli bir role sahiptir. İşlevlerini vücuttaki farklı mekanizmalarla sağlar. Bu mekanizmalar; hormonlar, dopamin, AMPK, egzersiz, diyet, immünoglobülinler ve lipokalin-2 ile ilişkilidir. Melanokortin sisteminin işleyişindeki bozukluklar başta çocukluk çağı obezitesi olmak üzere birçok metabolik sendroma sebep olur. Diyete bağlı veya genetik varyasyonların sebep olduğu bu durumların tedavi yollarını geliştirmek birçok hastalık için önemli olabilir. Bu derlemede, melanokortin sisteminin iştah ve enerji dengesindeki çalışma prensipleri ve besinlerle olan ilişkileri incelenmiştir.
References
- Greenhill, C. (2017). Osteoblast-derived lipocalin 2 suppresses appetite. Nature Reviews Endocrinology, 13(5), 250. https://doi.org/10.1038/nrendo.2017.30
- Morell-Azanza, Ojeda-Rodríguez, Giuranna, Azcona-SanJulián, Hebebrand, Marti, & Hinney. (2019). Melanocortin-4 Receptor and Lipocalin 2 Gene Variants in Spanish Children with Abdominal Obesity: Effects on BMI-SDS After a Lifestyle Intervention. Nutrients, 11(5), 960. https://doi.org/10.3390/nu11050960
- Butler, A. A., Girardet, C., Mavrikaki, M., Trevaskis, J. L., Macarthur, H., Marks, D. L., & Farr, S. A. (2017). A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling. Frontiers in Neuroscience, 11. Published. https://doi.org/10.3389/fnins.2017.00128
- Yeo, G. S., Chao, D. H. M., Siegert, A. M., Koerperich, Z. M., Ericson, M. D., Simonds, S. E., . . . Adan, R. A. (2021). The melanocortin pathway and energy homeostasis: From discovery to obesity therapy. Molecular Metabolism, 48, 101206. https://doi.org/10.1016/j.molmet.2021.101206
- Mosialou, I., Shikhel, S., Liu, J. M., Maurizi, A., Luo, N., He, Z., . . . Kousteni, S. (2017). Erratum: Corrigendum: MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature, 546(7658), 440. https://doi.org/10.1038/nature22808
- Gava, F. N., da Silva, A. A., Dai, X., Harmancey, R., Ashraf, S., Omoto, A. C., . . . do Carmo, J. M. (2021b). Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System. JACC: Basic to Translational Science, 6(1), 55–70. https://doi.org/10.1016/j.jacbts.2020.11.007
- Petropoulou, P. I., Mosialou, I., Shikhel, S., Hao, L., Panitsas, K., Bisikirska, B., . . . Kim, J. (2021). Lipocalin-2 is an anorexigenic signal in primates. Yearbook of Paediatric Endocrinology. Published. https://doi.org/10.1530/ey.18.14.2
Abstract
The appetite and energy balance has been tried to be exposed with researches for many years. Melanocortin system has an important role in maintaining this balance in the brain. It provides its functions with different mechanisms. The mechanisms; it is associated with hormones, dopamine, AMPK, exercise, diet, immunoglobulins and lipocalin-2. Malfunctions in the functioning of the melanocortin system cause many metabolic syndromes, especially childhood obesity. It may be important for many diseases to develop treatment methods for these conditions caused by diet-related or genetic variations. In this review, the working principles of the melanocortin system in appetite and energy balance and its relations with foods are examined.
References
- Greenhill, C. (2017). Osteoblast-derived lipocalin 2 suppresses appetite. Nature Reviews Endocrinology, 13(5), 250. https://doi.org/10.1038/nrendo.2017.30
- Morell-Azanza, Ojeda-Rodríguez, Giuranna, Azcona-SanJulián, Hebebrand, Marti, & Hinney. (2019). Melanocortin-4 Receptor and Lipocalin 2 Gene Variants in Spanish Children with Abdominal Obesity: Effects on BMI-SDS After a Lifestyle Intervention. Nutrients, 11(5), 960. https://doi.org/10.3390/nu11050960
- Butler, A. A., Girardet, C., Mavrikaki, M., Trevaskis, J. L., Macarthur, H., Marks, D. L., & Farr, S. A. (2017). A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling. Frontiers in Neuroscience, 11. Published. https://doi.org/10.3389/fnins.2017.00128
- Yeo, G. S., Chao, D. H. M., Siegert, A. M., Koerperich, Z. M., Ericson, M. D., Simonds, S. E., . . . Adan, R. A. (2021). The melanocortin pathway and energy homeostasis: From discovery to obesity therapy. Molecular Metabolism, 48, 101206. https://doi.org/10.1016/j.molmet.2021.101206
- Mosialou, I., Shikhel, S., Liu, J. M., Maurizi, A., Luo, N., He, Z., . . . Kousteni, S. (2017). Erratum: Corrigendum: MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature, 546(7658), 440. https://doi.org/10.1038/nature22808
- Gava, F. N., da Silva, A. A., Dai, X., Harmancey, R., Ashraf, S., Omoto, A. C., . . . do Carmo, J. M. (2021b). Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System. JACC: Basic to Translational Science, 6(1), 55–70. https://doi.org/10.1016/j.jacbts.2020.11.007
- Petropoulou, P. I., Mosialou, I., Shikhel, S., Hao, L., Panitsas, K., Bisikirska, B., . . . Kim, J. (2021). Lipocalin-2 is an anorexigenic signal in primates. Yearbook of Paediatric Endocrinology. Published. https://doi.org/10.1530/ey.18.14.2
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | December 30, 2021 |
| Submission Date | November 24, 2021 |
| Acceptance Date | December 30, 2021 |
| Published in Issue | Year 2021 |
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