Melanokortin Sistemi: İştah ve Enerji Homeostazı Etki Mekanizmaları

Year 2021, Volume: 3 Issue: 3, 212 - 219, 30.12.2021

Ela Altun , Sabiha Zeynep Aydenk Köseoğlu

https://doi.org/10.47769/izufbed.1027766

Abstract

İştah ve enerji dengesi uzun yıllardır araştırmalarla aydınlatılmaya çalışılmaktadır. Beyindeki melanokortin sistemi bu dengenin korunmasında önemli bir role sahiptir. İşlevlerini vücuttaki farklı mekanizmalarla sağlar. Bu mekanizmalar; hormonlar, dopamin, AMPK, egzersiz, diyet, immünoglobülinler ve lipokalin-2 ile ilişkilidir. Melanokortin sisteminin işleyişindeki bozukluklar başta çocukluk çağı obezitesi olmak üzere birçok metabolik sendroma sebep olur. Diyete bağlı veya genetik varyasyonların sebep olduğu bu durumların tedavi yollarını geliştirmek birçok hastalık için önemli olabilir. Bu derlemede, melanokortin sisteminin iştah ve enerji dengesindeki çalışma prensipleri ve besinlerle olan ilişkileri incelenmiştir.

Keywords

Melanokortin, İştah, Enerji dengesi, hormon, beslenme, çocukluk çağı obezitesi

Melanocortine System: Appetite and Energy Homeostasis Mechanisms

Abstract

The appetite and energy balance has been tried to be exposed with researches for many years. Melanocortin system has an important role in maintaining this balance in the brain. It provides its functions with different mechanisms. The mechanisms; it is associated with hormones, dopamine, AMPK, exercise, diet, immunoglobulins and lipocalin-2. Malfunctions in the functioning of the melanocortin system cause many metabolic syndromes, especially childhood obesity. It may be important for many diseases to develop treatment methods for these conditions caused by diet-related or genetic variations. In this review, the working principles of the melanocortin system in appetite and energy balance and its relations with foods are examined.

Keywords

Melanocortin Appetite Energy Balance Hormone Nutrition Chilhood Obesity

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