Sekundum Atriyal Septal Defektli Çocuklarda Galektin-3

Year 2023, Volume: 8 Issue: 4, 33 - 37, 05.12.2023

Fatma Özkul , Mustafa Argun , Süleyman Sunkak , Derya Koçer

https://doi.org/10.55694/jamer.1365421

Abstract

Amaç: Pediatrik popülasyonda galektin-3’ün kardiyak biyobelirteç olarak rolüne ilişkin sınırlı sayıda çalışma bulunmaktadır. Sekundum atriyal septal defekti (ASD) olan çocuklarda galektin-3 düzeyini ve bunun B-tip natriüretik peptidinin N-terminal prohormonu (NT-proBNP) ile ilişkisini araştırmayı amaçladık.

Gereç ve Yöntemler: Hasta grubunu sekundum ASD’li 27 hasta oluşturdu. Kontrol grubunu benzer yaş ve cinsiyette 30 sağlıklı çocuk oluşturdu. Transtorasik ekokardiyografi ile herhangi bir pencereden ölçülen en büyük ASD çapı ASD boyutu olarak kaydedildi. NT-ProBNP ve galektin-3 için kan örnekleri toplandı.

Bulgular: Sekundum ASD’li çocukların NT-ProBNP düzeyleri sağlıklı çocuklara göre anlamlı derecede yüksekti (p=0.003). Sekundum ASD’li çocukların galektin-3 düzeyleri sağlıklı çocuklarla benzerdi (p=0.377). Sekundum ASD’li çocuklarda galektin-3 ile NT-ProBNP düzeyleri arasında istatistiksel olarak önemli pozitif korelasyon mevcuttu (rho=0.454, p=0.017). Galektin-3 eğrisi altında kalan alan istatistiksel olarak anlamlı değildi (AUC=0.537; p=0.643).

Sonuç: Sekundum ASD’li hastalarda NT-ProBNP düzeyinde artış olmasına rağmen galektin-3 düzeyinde değişiklik olmadı. NT-ProBNP, sekundum ASD’nin tahmini için değerli bir biyobelirteç olmasına rağmen, galektin-3’ün bu hastalığı öngörmede rolü yoktu.

Keywords

Sekundum atriyal septal defekt, galektin-3, B-tip natriüretik peptidinin N-terminal prohormonu, çocuk

Ethical Statement

Çalışma, Sağlık Bilimleri Üniversitesi Kayseri Şehir Eğitim ve Araştırma Hastanesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı’nda Haziran 2020 – Ocak 2021 tarihleri arasında gerçekleştirildi. Kayseri Şehir Hastanesi Klinik Araştırmalar Etik Kurulu tarafından 30.04.2020 tarihli ve 43 nolu kararı ile uygun görüldü. Çalışmaya alınan tüm hasta ve kontrol grubu çocukların aileleri bilgilendirilerek aydınlatılmış onamları alındı

Supporting Institution

yok

Project Number

43

Galectin-3 in Children with Secundum Atrial Septal Defect

Abstract

Aim: There is a limited number of studies on the role of galectin-3 as a cardiac biomarker in the pediatric population. We aimed to investigate galectin-3 level and its relationship with N-terminal prohormone of brain natriuretic peptide (NT-proBNP) in children with secundum atrial septal defect (ASD).

Material and Methods: Twenty-seven patients with secundum ASD formed the patient group. Thirty healthy children of similar age and gender formed the control group. The largest ASD diameter measured from any window with transthoracic echocardiography was recorded as the ASD size. Blood samples were collected for NT-ProBNP and galectin-3.

Results: Children with secundum ASD had significantly higher NT-ProBNP levels compared with the healthy children (p=0.003). Galectin-3 levels of children with secundum ASD were similar to those of the healthy children (p=0.377). There was a statistically positive correlation between galectin-3 and NT-ProBNP levels in children with secundum ASD (rho=0.454, p=0.017). The area under the curve of galectin-3 was not statistically significant (AUC=0.537; p=0.643).

Conclusion: Although there was an increase in NT-ProBNP level in patients with secundum ASD, galectin-3 level did not change. Although NT-ProBNP was a valuable biomarker for the prediction of secundum ASD, galectin-3 had no role in predicting this disease.

Keywords

secundum atrial septal defect, galectin-3, N-terminal prohormone of brain natriuretic peptide, child

Project Number

43

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