Review
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Organoid As a Novel Technology for Disease Modeling

Year 2021, Volume: 5 Issue: 1, 94 - 101, 26.02.2021

Tolga Sever , Ilgin Cevık , Gizem Çalıbaşı Koçal , Ender Berat Ellidokuz , Yasemin Başbınar

https://doi.org/10.30621/jbachs.868837

Abstract

The organoid technology is capable to create more real-like in vitro models in terms of structure and function of the origin of the tissue. Since the three-dimensional model is able to illustrate disease pathology, cell differentiation, and recapitulation of self-renewal, lead organoid technology as a promising disease model to fill the gap between conventional two-dimensional, and in vivo disease models. The review describes the recent development of organoid disease modeling approaches.

Keywords

Organoid Disease modeling Stem cell

Supporting Institution

Dokuz Eylul University Scientific Research Project Coordination Unit

Project Number

2018.KB.SAG.039

References

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Year 2021, Volume: 5 Issue: 1, 94 - 101, 26.02.2021

Tolga Sever , Ilgin Cevık , Gizem Çalıbaşı Koçal , Ender Berat Ellidokuz , Yasemin Başbınar

https://doi.org/10.30621/jbachs.868837

Abstract

Project Number

2018.KB.SAG.039

References

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  • 2. Byrne AT, Alférez DG, Amant F, Annibali D, Arribas J, Biankin A V., et al. Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nature Reviews Cancer. 2017.
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  • 4. Mahe MM, Aihara E, Schumacher MA, Zavros Y, Montrose MH, Helmrath MA, et al. Establishment of Gastrointestinal Epithelial Organoids. Curr Protoc Mouse Biol. 2013;
  • 5. Takebe T, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature. 2013;
  • 6. Schreurs RRCE, Baumdick ME, Sagebiel AF, Kaufmann M, Mokry M, Klarenbeek PL, et al. Human Fetal TNF-α-Cytokine-Producing CD4 + Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life. Immunity. 2019;
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  • 19. Hill SJ, Decker B, Roberts EA, Horowitz NS, Muto MG, Worley MJ, et al. Prediction of DNA repair inhibitor response in short-term patient-derived ovarian cancer organoids. Cancer Discov. 2018.
  • 20. Fujii M, Shimokawa M, Date S, Takano A, Matano M, Nanki K, et al. A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis. Cell Stem Cell. 2016.
  • 21. Yeung TM, Gandhi SC, Wilding JL, Muschel R, Bodmer WF. Cancer stem cells from colorectal cancer-derived cell lines. Proc Natl Acad Sci U S A. 2010; 22. Onuma K, Ochiai M, Orihashi K, Takahashi M, Imai T, Nakagama H, et al. Genetic reconstitution of tumorigenesis in primary intestinal cells. Proc Natl Acad Sci U S A. 2013.
  • 23. Matano M, Date S, Shimokawa M, Takano A, Fujii M, Ohta Y, et al. Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids. Nat Med. 2015.
  • 24. Scanu T, Spaapen RM, Bakker JM, Pratap CB, Wu L en, Hofland I, et al. Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma. Cell Host Microbe. 2015.
  • 25. Davies H, Glodzik D, Morganella S, Yates LR, Staaf J, Zou X, et al. HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. Nat Med. 2017; 26. Driehuis E, Kretzschmar K, Clevers H. Establishment of patient-derived cancer organoids for drug-screening applications. Nat Protoc. 2020.
  • 27. Vlachogiannis G, Hedayat S, Vatsiou A, Jamin Y, Fernández-Mateos J, Khan K, et al. Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science (80- ). 2018.
  • 28. Ganesh K, Wu C, O’Rourke KP, Szeglin BC, Zheng Y, Sauvé CEG, et al. A rectal cancer organoid platform to study individual responses to chemoradiation. Nat Med. 2019.
  • 29. Yoshida GJ. Applications of patient-derived tumor xenograft models and tumor organoids. Journal of Hematology and Oncology. 2020.
  • 30. Benson CA, Powell HR, Liput M, Dinham S, Freedman DA, Ignatowski TA, et al. Immune Factor, TNFα, Disrupts Human Brain Organoid Development Similar to Schizophrenia—Schizophrenia Increases Developmental Vulnerability to TNFα. Front Cell Neurosci. 2020.
  • 31. Daviaud N, Chevalier C, Friedel RH, Zou H. Distinct Vulnerability and Resilience of Human Neuroprogenitor Subtypes in Cerebral Organoid Model of Prenatal Hypoxic Injury. Front Cell Neurosci. 2019.
  • 32. Simmnacher K, Lanfer J, Rizo T, Kaindl J, Winner B. Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Frontiers in Cellular Neuroscience. 2020.
  • 33. Chen A, Guo Z, Fang L, Bian S. Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders. Frontiers in Cellular Neuroscience. 2020.
  • 34. Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, et al. Multiplex genome engineering using CRISPR/Cas systems. Science (80- ). 2013.
  • 35. Zou X, Owusu M, Harris R, Jackson SP, Loizou JI, Nik-Zainal S. Validating the concept of mutational signatures with isogenic cell models. Nat Commun. 2018.
  • 36. Perez-Lanzon M, Kroemer G, Maiuri MC. Organoids for Modeling Genetic Diseases. In: International Review of Cell and Molecular Biology. 2018.
  • 37. De Boeck K, Vermeulen F, Dupont L. The diagnosis of cystic fibrosis. Presse Medicale. 2017.
  • 38. Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, et al. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell. 2013.
  • 39. Artegiani B, Clevers H. Use and application of 3D-organoid technology. Human molecular genetics. 2018.
  • 40. Jo J, Xiao Y, Sun AX, Cukuroglu E, Tran HD, Göke J, et al. Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons. Cell Stem Cell. 2016.
  • 41. Pasca AM, Sloan SA, Clarke LE, Tian Y, Makinson CD, Huber N, et al. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat Methods. 2015.
  • 42. Hossein F. An overview of the current medical literature on Zika virus. Biophysical Reviews. 2020. 43. Qian X, Nguyen HN, Jacob F, Song H, Ming GL. Using brain organoids to understand Zika virus-induced microcephaly. Dev. 2017.
  • 44. Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med. 2016.
  • 45. Zhou T, Tan L, Cederquist GY, Fan Y, Hartley BJ, Mukherjee S, et al. High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain. Cell Stem Cell. 2017.
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There are 87 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Reviews
Authors

Tolga Sever 0000-0002-0135-0243

Ilgin Cevık 0000-0002-7122-1260

Gizem Çalıbaşı Koçal 0000-0002-3201-4752

Ender Berat Ellidokuz 0000-0002-3201-4752

Yasemin Başbınar 0000-0001-9439-2217

Project Number 2018.KB.SAG.039
Publication Date February 26, 2021
Submission Date January 6, 2021
Published in Issue Year 2021 Volume: 5 Issue: 1

Cite

APA Sever, T., Cevık, I., Çalıbaşı Koçal, G., Ellidokuz, E. B., et al. (2021). Organoid As a Novel Technology for Disease Modeling. Journal of Basic and Clinical Health Sciences, 5(1), 94-101. https://doi.org/10.30621/jbachs.868837
AMA Sever T, Cevık I, Çalıbaşı Koçal G, Ellidokuz EB, Başbınar Y. Organoid As a Novel Technology for Disease Modeling. JBACHS. February 2021;5(1):94-101. doi:10.30621/jbachs.868837
Chicago Sever, Tolga, Ilgin Cevık, Gizem Çalıbaşı Koçal, Ender Berat Ellidokuz, and Yasemin Başbınar. “Organoid As a Novel Technology for Disease Modeling”. Journal of Basic and Clinical Health Sciences 5, no. 1 (February 2021): 94-101. https://doi.org/10.30621/jbachs.868837.
EndNote Sever T, Cevık I, Çalıbaşı Koçal G, Ellidokuz EB, Başbınar Y (February 1, 2021) Organoid As a Novel Technology for Disease Modeling. Journal of Basic and Clinical Health Sciences 5 1 94–101.
IEEE T. Sever, I. Cevık, G. Çalıbaşı Koçal, E. B. Ellidokuz, and Y. Başbınar, “Organoid As a Novel Technology for Disease Modeling”, JBACHS, vol. 5, no. 1, pp. 94–101, 2021, doi: 10.30621/jbachs.868837.
ISNAD Sever, Tolga et al. “Organoid As a Novel Technology for Disease Modeling”. Journal of Basic and Clinical Health Sciences 5/1 (February 2021), 94-101. https://doi.org/10.30621/jbachs.868837.
JAMA Sever T, Cevık I, Çalıbaşı Koçal G, Ellidokuz EB, Başbınar Y. Organoid As a Novel Technology for Disease Modeling. JBACHS. 2021;5:94–101.
MLA Sever, Tolga et al. “Organoid As a Novel Technology for Disease Modeling”. Journal of Basic and Clinical Health Sciences, vol. 5, no. 1, 2021, pp. 94-101, doi:10.30621/jbachs.868837.
Vancouver Sever T, Cevık I, Çalıbaşı Koçal G, Ellidokuz EB, Başbınar Y. Organoid As a Novel Technology for Disease Modeling. JBACHS. 2021;5(1):94-101.
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