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Clinical Characteristics of Patients Initiated on Long-Term Noninvasive Ventilation Support: A Single-Center Experience

Year 2024, , 168 - 173, 03.01.2025
https://doi.org/10.26650/jchild.2024.1507342

Abstract

Objective: Long-term noninvasive ventilation (NIV) support is increasingly being used by pediatricians for children with complex medical diseases. However, data on NIV support among children in Turkiye are limited.

Methods: This study included children who received long-term NIV support between July 2022 and July 2024 at a single center. Demographic and clinical characteristics and short-term clinical outcomes were retrospectively evaluated.

Results: A total of 30 patients were included. The median age at NIV initiation was 39.5 months (range: 9–108 months), and the most common underlying etiology was cardiovascular diseases (n = 9, 30%). Twenty-six patients were discharged with long-term NIV support, with a median discharge time of 5.5 days (range: 3–13 days) after NIV initiation. Of the 26 patients discharged with NIV support, four died during follow-up. Three patients, all of whom were from the cardiovascular group, no longer required respiratory support.

Conclusions: NIV can be used effectively for a wide variety of diseases in children. Understanding the current status of NIV support in our clinical setting may help us design a protocol to improve future outcomes.

References

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  • Mayer OH, Amin R, Sawnani H, Shell R, Katz SL; RIND Study Group. Respiratory Insufficiency in Neuromuscular Disease (RIND): A Delphi Study to Establish Consensus Criteria for Define and Diagnose Hypoventilation in Pediatric Neuromuscular Disease. J Neuromuscul Dis. 2023;10(6):1075-1082. google scholar
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  • Castro-Codesal ML, Dehaan K, Featherstone R, Bedi PK, Martinez Carrasco C, Katz SL, et al. . Long-term noninvasive ventilation therapies for children: A scoping review. Sleep Med Rev. 2018;37:148-158. google scholar
  • Ikeda A, Tsuji M, Goto T, Iai M. Long-term home noninvasive positive pressure ventilation in children: Results from a single center in Japan. Brain Dev. 2018;40(7):558-565. google scholar
  • Racca F, Berta G, Sequi M, Bignamini E, Capello E, Cutrera R, et al.; LTV Pediatric Italian Network. Long-term home ventilation of children in Italy: a national survey. Pediatr Pulmonol. 2011;46(6):566-72. google scholar
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Year 2024, , 168 - 173, 03.01.2025
https://doi.org/10.26650/jchild.2024.1507342

Abstract

References

  • Atag E, Krivec U, Ersu R. Noninvasive ventilation for children with chronic lung disease. Front Pediatr. 2020;11(8):561639. google scholar
  • Pavone M, Verrillo E, Caldarelli V, Ullmann N, Cutrera R. Noninvasive positive pressure ventilation in children. Early Hum Dev. 2013;89(Suppl 3):S25-31. google scholar
  • MacLean JE, Fauroux B. Long-term noninvasive ventilation in children: Transition from hospital to home. Paediatr Respir Rev. 2023;(47):3-10. google scholar
  • Amaddeo A, Frapin A, Fauroux B. Long-term noninvasive ventilation in children. Lancet Respir Med. 2016;(12):999-1008. google scholar
  • Chatwin M, Bush A, Simonds AK. Outcomes of goal-directed noninvasive ventilation and mechanical insufflation/exsufflation in spinal muscular atrophy type I. Arch Dis Child. 2011;96(5):426-32. google scholar
  • Ishikawa Y, Miura T, Ishikawa Y, Aoyagi T, Ogata H, Hamada S et al. Duchenne muscular dystrophy: survival by cardio-respiratory interventions. Neuromuscul Disord. 2011;21(1):47-51. google scholar
  • Oskoui M, Levy G, Garland CJ, Gray JM, O’Hagen J, De Vivo DC,et al. The natural history of spinal muscular atrophy type 1. Neurology. 2007;69(20):1931-6 google scholar
  • McDougall CM, Adderley RJ, Wensley DF, Seear MD. Long-term ventilation in children: longitudinal trends and outcomes. Arch Dis Child. 2013;98(9):660-5. google scholar
  • Praud JP. Long-Term Non-invasive Ventilation in Children: Current Use, Indications, and Contraindications. Front Pediatr. 2020;5(8):584334. google scholar
  • Mayer OH, Amin R, Sawnani H, Shell R, Katz SL; RIND Study Group. Respiratory Insufficiency in Neuromuscular Disease (RIND): A Delphi Study to Establish Consensus Criteria for Define and Diagnose Hypoventilation in Pediatric Neuromuscular Disease. J Neuromuscul Dis. 2023;10(6):1075-1082. google scholar
  • Berry RB, Quan SF, Abreu AR, Bibbs ML, DelRosso L et al. The AASM Manual for Sleep Scoring and Associated Events: Rules, Terminology and Technical Specifications. American Academy of Sleep Medicine; 2020 google scholar
  • Chatwin M, Tan HL, Bush A, Rosenthal M, Simonds AK. Long-term noninvasive ventilation in children: impact on survival and transition to adult care. PLoS One. 2015;10(5):e0125839. google scholar
  • Castro-Codesal ML, Dehaan K, Featherstone R, Bedi PK, Martinez Carrasco C, Katz SL, et al. . Long-term noninvasive ventilation therapies for children: A scoping review. Sleep Med Rev. 2018;37:148-158. google scholar
  • Ikeda A, Tsuji M, Goto T, Iai M. Long-term home noninvasive positive pressure ventilation in children: Results from a single center in Japan. Brain Dev. 2018;40(7):558-565. google scholar
  • Racca F, Berta G, Sequi M, Bignamini E, Capello E, Cutrera R, et al.; LTV Pediatric Italian Network. Long-term home ventilation of children in Italy: a national survey. Pediatr Pulmonol. 2011;46(6):566-72. google scholar
  • Amin R, Sayal P, Syed F, Chaves A, Moraes TJ, MacLusky I. Pediatric long-term home mechanical ventilation: 20 years of follow-up at one Canadian center. Pediatr Pulmonol. 2014;49(8):816-24. google scholar
  • Oktem S, Cakir E, Uyan ZS, Karadag B, Hamutcu RE, Kiyan G et al. Diaphragmatic paralysis after pediatric heart surgery: usefulness of non-invasive ventilation. Int J Pediatr Otorhinolaryngol. 2010;74(4):430-1. google scholar
  • Kovacikova L, Dobos D, Zahorec M. Noninvasive positive pressure ventilation for bilateral diaphragm paralysis after pediatric cardiac surgery. Interact Cardiovasc Thorac Surg. 2009;8(1):171-2. google scholar
  • Fernândez Lafever S, Toledo B, Leiva M, Padron M, Balseiro M, Carrillo A, Lopez-Herce J. Non-invasive mechanical ventilation after heart surgery in children. BMC Pulm Med. 2016;16(1):167. google scholar
There are 19 citations in total.

Details

Primary Language English
Subjects Pediatric Chest Diseases
Journal Section Research Articles
Authors

Cansu Yılmaz Yegit 0000-0001-8239-4776

Esin Aldemir 0000-0001-6141-7940

Erkut Ozturk 0000-0002-1762-3269

Mehmet Arda Kılınç 0000-0001-9121-2188

Mehmet Gümüştaş This is me 0000-0002-4846-5398

Hasan Onal 0000-0001-9676-7086

Alican Hatemi This is me 0000-0002-6202-3262

Merih Çetinkaya This is me 0000-0002-7344-8637

Publication Date January 3, 2025
Submission Date July 2, 2024
Acceptance Date October 31, 2024
Published in Issue Year 2024

Cite

APA Yılmaz Yegit, C., Aldemir, E., Ozturk, E., Kılınç, M. A., et al. (2025). Clinical Characteristics of Patients Initiated on Long-Term Noninvasive Ventilation Support: A Single-Center Experience. Çocuk Dergisi, 24(3), 168-173. https://doi.org/10.26650/jchild.2024.1507342
AMA Yılmaz Yegit C, Aldemir E, Ozturk E, Kılınç MA, Gümüştaş M, Onal H, Hatemi A, Çetinkaya M. Clinical Characteristics of Patients Initiated on Long-Term Noninvasive Ventilation Support: A Single-Center Experience. Çocuk Dergisi. January 2025;24(3):168-173. doi:10.26650/jchild.2024.1507342
Chicago Yılmaz Yegit, Cansu, Esin Aldemir, Erkut Ozturk, Mehmet Arda Kılınç, Mehmet Gümüştaş, Hasan Onal, Alican Hatemi, and Merih Çetinkaya. “Clinical Characteristics of Patients Initiated on Long-Term Noninvasive Ventilation Support: A Single-Center Experience”. Çocuk Dergisi 24, no. 3 (January 2025): 168-73. https://doi.org/10.26650/jchild.2024.1507342.
EndNote Yılmaz Yegit C, Aldemir E, Ozturk E, Kılınç MA, Gümüştaş M, Onal H, Hatemi A, Çetinkaya M (January 1, 2025) Clinical Characteristics of Patients Initiated on Long-Term Noninvasive Ventilation Support: A Single-Center Experience. Çocuk Dergisi 24 3 168–173.
IEEE C. Yılmaz Yegit, E. Aldemir, E. Ozturk, M. A. Kılınç, M. Gümüştaş, H. Onal, A. Hatemi, and M. Çetinkaya, “Clinical Characteristics of Patients Initiated on Long-Term Noninvasive Ventilation Support: A Single-Center Experience”, Çocuk Dergisi, vol. 24, no. 3, pp. 168–173, 2025, doi: 10.26650/jchild.2024.1507342.
ISNAD Yılmaz Yegit, Cansu et al. “Clinical Characteristics of Patients Initiated on Long-Term Noninvasive Ventilation Support: A Single-Center Experience”. Çocuk Dergisi 24/3 (January 2025), 168-173. https://doi.org/10.26650/jchild.2024.1507342.
JAMA Yılmaz Yegit C, Aldemir E, Ozturk E, Kılınç MA, Gümüştaş M, Onal H, Hatemi A, Çetinkaya M. Clinical Characteristics of Patients Initiated on Long-Term Noninvasive Ventilation Support: A Single-Center Experience. Çocuk Dergisi. 2025;24:168–173.
MLA Yılmaz Yegit, Cansu et al. “Clinical Characteristics of Patients Initiated on Long-Term Noninvasive Ventilation Support: A Single-Center Experience”. Çocuk Dergisi, vol. 24, no. 3, 2025, pp. 168-73, doi:10.26650/jchild.2024.1507342.
Vancouver Yılmaz Yegit C, Aldemir E, Ozturk E, Kılınç MA, Gümüştaş M, Onal H, Hatemi A, Çetinkaya M. Clinical Characteristics of Patients Initiated on Long-Term Noninvasive Ventilation Support: A Single-Center Experience. Çocuk Dergisi. 2025;24(3):168-73.