Abstract
Amaç: Rotavirüs, çocuklarda en sık görülen ve elektrolit düzensizliği, şiddetli dehidratasyon, hipovolemik şok ve ölümle sonuçlanabilen akut gastroenterit nedenidir. Kesin tanı için geliştirilmiş serolojik yöntemler mevcut olsa da bu yöntemlere ulaşmak her zaman kolay olmayabilir. Bu çalışma rotavirüs tanısına yardımcı olan parametreleri değerlendirmeyi amaçlamaktadır.
Gereç ve Yöntemler: Akut gastroenterit nedeniyle hastanemize başvuran 1 ay-18 yaş arası 1539 çocuğu retrospektif olarak inceledik. Hastalar rotavirüs pozitif ve rotavirüs negatif olarak iki gruba ayrıldı. RV-pozitif grupta 745 hasta ve RV-negatif grupta 794 hasta vardı.
Bulgular: Ortalama RBC (p=0,005), Hb (p<0,001), Htc (p<0,001), MCV (p<0,001), nötrofil (p=0,001), platelet lenfosit oranı (p=0,003), nötrofil lenfosit oranı (p<0,001), eozinofil lenfosit oranı (p<0,001) seviyeleri RV-pozitif grupta anlamlı olarak daha düşüktü. Ortalama platelet düzeyi (p=0,005) ve ortalama lenfosit düzeyi (p<0,001) RV-pozitif grupta anlamlı olarak daha yüksekti.
Sonuç: Rotavirüs gastroenteritinde birçok hematolojik parametre etkilenmiştir. RBC, Hb, Htc, MCV, ortalama trombosit düzeyi, ortalama nötrofil düzeyi, ortalama lenfosit düzeyi, trombosit/lenfosit oranı, nötrofil/lenfosit oranı, eozinofil/lenfosit oranı ve rotavirüs gastroenteriti için destekleyici olabilir
Keywords
Supporting Institution
yok
Project Number
yok
References
- King CK, Glass R, Bresee JS, Duggan C. Centers for Disease Control and Prevention. Managing acute gastroenteritis among children. MMWR Recomm Rep. 2003; 52(RR16): 1-16. google scholar
- King CK, Glass R, Bresee J, et al. Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy. MMWR Recomm Rep. 2003; 52(RR-16): 1-16. google scholar
- El-Radhi AS. Fever in Common Infectious Diseases. Clinical Manual of Fever in Children. 2019; 2: 85-140. google scholar
- Parashar UD, Burton A, Lanata C et al. Global Mortality Associated with Rotavirus Disease among Children in 2004. The Journal of Infectious Diseases. 2009; 9-15. google scholar
- Fischer TK. Incidence of hospitalizations due to rotavirus gastroenteritis in Denmark, Acta Paediatr. 2001; 90(9): 1073-5. google scholar
- Karavanaki K, Polychronopoulou S, Giannaki M, et al. Transient and chronic neutropenias detected in children with different viral and bacterial infections. Acta Paediatr. 2006; 95: 565-572. google scholar
- Donowitz M, Kokke FT, Saidi R. Evaluation of patients with chronic diarrhea. N Engl J Med. 1995; 332(11): 725-729. google scholar
- Nehring SM, Goyal A, Bansal P, Patel BC. C reactive protein (CRP). Treasure Island, FL: StatPearls. 2020. google scholar
- Arun P, Krishnasami K, Gunasekeran P, et al. Gender Distribution among Children in Rotavirus Gastroenteritis Diarrhea in Chennai. SAS J. Med. 2017; 7 :199-201. google scholar
- Fang ZY, Yang H, Qi J et al., Diversity of Rotavirus Strains among Children with Acute Diarrhea in China: 1998-2000 Surveillance Study. J Clin Microbiol. 2004: 5; 1875-8. google scholar
- Mete E, Akelma AZ, Cizmeci MN, et al. Decreased Mean Platelet Volume in Children with Acute Rotavirus Gastroenteritis. Platelets. 2014; 25 (1) : 51-54. google scholar
- Dalgıç N, Haşim Ö, Pullu M, et al. Is Rotavirus Diarrhea a Systemic Viral Infection? Çocuk Enf Derg. 2010; 4: 48-55. google scholar
- Bozdayi G, Dogan B, Dalgic B, et al. Diversity of human rotavirus G9 among children in Turkey. J Med Virol. 2008; 80: 733-40. google scholar
- Cook S, Glass R, Lebaron C. Global seasonality of rotavirus infections. Bull World Health Org. 1990; 68:171-177. google scholar
- Sanchez-Fauquier A, MonteroV, Colomina J, et. al. Aisa. Global study of viral diarrhea in hospitalized children in Spain: Results of Structural Surveillance of Viral Gastroenteritis Net Work (VIGESS-net) 2006-2008. J Clin Virology. 2011; 11: 353- 358. google scholar
- Tajiri H, Takeuchi Y, Takano T, et al. The Burden of Rotavirus Gastroenteritis and Hospital- acquired Rotavirus Gastroenteritis Among Children Aged Less Than 6 Years in Japan: A Retrospective, Multicenter Epidemiological Survey. BMC Pediatrics. 2013, 13: 83. google scholar
- Greenberg DE, Wilimas JA, Buckingham SC. Hematologic findings in children with 19) rotavirus-positive and -negative diarrhea. Pediatr Hematol Oncol. 2003; 20: 453-6. google scholar
- Ebersole JL, Cappelli D: Acute-phase reactants in infections and inflammatory diseases. Periodontol. 2000, 23: 19-49. google scholar
- Ware RE. Hemolytic Anemias. In: Nathan DG, Orkin SH, Ginsburg D, Look AT (6th ed): Nathan and Oski’s Hematology of Infancy and Childhood. W.B. Saunders, 2003: 521- 721 google scholar
- Buchanan GR. The mild anemia of acute infection. Pediatr Infect DisJ. 1985; 4: 225-228. google scholar
- Kelly JT, Busse WW. Host immune responses to rhinovirus: mechanisms in asthma. J Allergy Clin Immun.2008; 122(4): 671682. google scholar
Abstract
Objective: Rotavirus is the most frequent cause of infectious acute gastroenteritis in children and may result in electrolyte imbalance, severe dehydration, hypovolemic shock, and death. Even though improved serological methods for definitive diagnosis exist, these methods may not always be easy to reach. This study aims to evaluate the parameters that help the diagnosis of rotavirus gastroenteritis.
Material and Methods: We retrospectively reviewed 1,539 children aged 1 month to 18 years who had been admitted to our hospital for acute gastroenteritis. Patients were divided into two groups: rotavirus positive and rotavirus negative. There were 745 patients in the RV-positive group and 794 patients in the RV-negative group.
Results: The mean RBC (p=0.005), Hb (p<0.001), Htc (p<0.001), MCV (p<0.001), neutrophil (p=0.001), PLR (p=0.003), NLR (p<0.001), and ELR (p<0.001) levels were significantly lower in the RV-positive group. The mean PLT level (p=0.005) and the mean lymphocyte level (p<0.001) were significantly higher in the RV-positive group.
Conclusion: Several hematological parameters were influenced in rotavirus gastroenteritis. RBC, Hb, Htc, MCV, the mean platelet level, the mean neutrophil level, the mean lymphocyte level, platelet /lymphocyte ratio, neutrophil/lymphocyte ratio, and the eosinophil/lymphocyte ratio could be supportive for rotavirus gastroenteritis.
Keywords
Project Number
yok
References
- King CK, Glass R, Bresee JS, Duggan C. Centers for Disease Control and Prevention. Managing acute gastroenteritis among children. MMWR Recomm Rep. 2003; 52(RR16): 1-16. google scholar
- King CK, Glass R, Bresee J, et al. Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy. MMWR Recomm Rep. 2003; 52(RR-16): 1-16. google scholar
- El-Radhi AS. Fever in Common Infectious Diseases. Clinical Manual of Fever in Children. 2019; 2: 85-140. google scholar
- Parashar UD, Burton A, Lanata C et al. Global Mortality Associated with Rotavirus Disease among Children in 2004. The Journal of Infectious Diseases. 2009; 9-15. google scholar
- Fischer TK. Incidence of hospitalizations due to rotavirus gastroenteritis in Denmark, Acta Paediatr. 2001; 90(9): 1073-5. google scholar
- Karavanaki K, Polychronopoulou S, Giannaki M, et al. Transient and chronic neutropenias detected in children with different viral and bacterial infections. Acta Paediatr. 2006; 95: 565-572. google scholar
- Donowitz M, Kokke FT, Saidi R. Evaluation of patients with chronic diarrhea. N Engl J Med. 1995; 332(11): 725-729. google scholar
- Nehring SM, Goyal A, Bansal P, Patel BC. C reactive protein (CRP). Treasure Island, FL: StatPearls. 2020. google scholar
- Arun P, Krishnasami K, Gunasekeran P, et al. Gender Distribution among Children in Rotavirus Gastroenteritis Diarrhea in Chennai. SAS J. Med. 2017; 7 :199-201. google scholar
- Fang ZY, Yang H, Qi J et al., Diversity of Rotavirus Strains among Children with Acute Diarrhea in China: 1998-2000 Surveillance Study. J Clin Microbiol. 2004: 5; 1875-8. google scholar
- Mete E, Akelma AZ, Cizmeci MN, et al. Decreased Mean Platelet Volume in Children with Acute Rotavirus Gastroenteritis. Platelets. 2014; 25 (1) : 51-54. google scholar
- Dalgıç N, Haşim Ö, Pullu M, et al. Is Rotavirus Diarrhea a Systemic Viral Infection? Çocuk Enf Derg. 2010; 4: 48-55. google scholar
- Bozdayi G, Dogan B, Dalgic B, et al. Diversity of human rotavirus G9 among children in Turkey. J Med Virol. 2008; 80: 733-40. google scholar
- Cook S, Glass R, Lebaron C. Global seasonality of rotavirus infections. Bull World Health Org. 1990; 68:171-177. google scholar
- Sanchez-Fauquier A, MonteroV, Colomina J, et. al. Aisa. Global study of viral diarrhea in hospitalized children in Spain: Results of Structural Surveillance of Viral Gastroenteritis Net Work (VIGESS-net) 2006-2008. J Clin Virology. 2011; 11: 353- 358. google scholar
- Tajiri H, Takeuchi Y, Takano T, et al. The Burden of Rotavirus Gastroenteritis and Hospital- acquired Rotavirus Gastroenteritis Among Children Aged Less Than 6 Years in Japan: A Retrospective, Multicenter Epidemiological Survey. BMC Pediatrics. 2013, 13: 83. google scholar
- Greenberg DE, Wilimas JA, Buckingham SC. Hematologic findings in children with 19) rotavirus-positive and -negative diarrhea. Pediatr Hematol Oncol. 2003; 20: 453-6. google scholar
- Ebersole JL, Cappelli D: Acute-phase reactants in infections and inflammatory diseases. Periodontol. 2000, 23: 19-49. google scholar
- Ware RE. Hemolytic Anemias. In: Nathan DG, Orkin SH, Ginsburg D, Look AT (6th ed): Nathan and Oski’s Hematology of Infancy and Childhood. W.B. Saunders, 2003: 521- 721 google scholar
- Buchanan GR. The mild anemia of acute infection. Pediatr Infect DisJ. 1985; 4: 225-228. google scholar
- Kelly JT, Busse WW. Host immune responses to rhinovirus: mechanisms in asthma. J Allergy Clin Immun.2008; 122(4): 671682. google scholar
Details
| Primary Language | English |
|---|---|
| Subjects | Paediatrics |
| Journal Section | Research Articles |
| Authors | |
| Project Number | yok |
| Publication Date | June 30, 2023 |
| Published in Issue | Year 2023 Volume: 23 Issue: 2 |
