Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience

Year 2019, Volume: 9 Issue: 4, 359 - 364, 31.12.2019

Vildan Güngörer , Ebru Yılmaz Keskin , Tunç Fışgın

https://doi.org/10.16899/jcm.605404

Cited By: 1

Abstract

Abstract

Aim: Analysis of the data of children following stem cell transplantation.

Materials and Methods: A total of 44 children who received stem cell
transplant between February 2009 and May 2011 were evaluated retrospectively.

Results: Among the patients with a mean age of 9.6 ± 4.63 years, 20 (45.5%) were male, whereas 24 (54.5%) were
female. The initial diagnosis of the patients with decreasing order of
frequency was as follows: thalassemia major (n=15), acute leukemia (n=9),
Fanconi aplastic anemia (n=6), aplastic anemia (n=5) and other disorders (n=9).
Disease-free survival in two years was observed in 27 (61.3%) of patients.
Relapse occurred in 8 (18.1%) patients, whereas 9 (20.4%) patients died. The
mortality was transplant-related in two cases, whereas it was due to
progression of the underlying disease in 7 (15.9%) patients.

Conclusion: As the stem cell transplantation has become widespread
in Türkiye recently, its data are valuable. We found high incidence of
mucositis and infection due to myeloablative regimens. The limitation of our
study is the small number of patients included. 
Though, results obtained here are similar to those of national and
international studies. 

Keywords

Hematopoietic stem cell transplantation, prognosis, transplant-related mortality

Supporting Institution

None

Thanks

None

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