Çölyak Hastalığı Deneyimimiz: 94 Hastanın Demografik Özellikleri, Laboratuvar Bulguları ve Eşlik Eden Hastalıklar

Year 2021, Volume: 11 Issue: 3, 364 - 368, 24.05.2021

Ömer Öztürk , Mustafa Kaplan , Ben Azir Begum Hymabaccus Muradi , Nurefşan Çihangiroğlu , İlyas Tenlik , Volkan Gökbulut , Derya Arı , Emin Altıparmak

https://doi.org/10.16899/jcm.870394

Abstract

Amaç: Çölyak Hastalığı (ÇH) toplumun yüzde %1’ini etkileyen, diğer otoimmun hastalıklarla birliktelik gösteren ve ekstraintestinal manisfestasyonlara sahip otoimmun bir hastalıktır. Bu çalışmada 94 hastanın demografik ve laboratuvar bulgularını, kansızlık, osteoporoz ve diğer otoimmun hastalıklar ile ilişkisini araştırdık.
Gereç ve Yöntem: Bu çalışma Ocak 2014-Aralık 2019 tarihleri arasında ÇH tanısı ile takipli 94 hastanın hasta kayıtları incelenerek retrospektif olarak yapılmıştır.
Bulgular: Hastaların 74’ü kadın (%79), 20’si erkekti (%21). Hastaların ortalama yaşı 35 idi (18-73). Ortalama hastalık süresi 6.6 yıldı (0-29). 81 hastada anti-endomisyum Ig A pozitifliği (%86) ,87 hastada doku transglutaminaz Ig A pozitifliği (%93) ve 45 hastada doku transglutaminaz Ig G pozitifliği saptandı (%48). 14 hastada hipotiroidi (%15) ve 8 hastada diabetes mellitus (%9) saptandı. 61 hastada kemik mineral dansitometri sonucunda osteoporoz veya osteopeni saptandı (%65). Ferritin sonuçlarına göre hastaların yarısında, transferrin saturasyonunu sonucuna göre ise %47’sinde demir eksikliği mevcuttu. 13 hastada B12 eksikliği (%14), 24 hastada folik asit eksikliği mevcuttu (%26). Hastaların %74’ünde D vitamin eksikliği saptandı. 10 hastada TSH değeri 4.5 mIU/L’den büyük saptandı. Hipotiroidi oranı %10’larda iken anti-TPO antikor pozitifliği %40, anti-TG pozitifliği ise %38 idi.
Sonuç: ÇH demir, folat, vitamin B12 ve vitamin D eksikliği ve bunlara bağlı kansızlık ve osteoporoz ile ilişkili olup hastalığa sıklıkla otoimmun tiroid hastalıkları ve diyabet eşlik etmektedir.

Keywords

Çölyak hastalığı, hipotiroidi, osteoporoz, anemi

Our Celiac Disease Experience: Demographic Characteristics, Laboratory Findings and Concomitant Diseases of 94 Patients

Abstract

Aim: Celiac Disease (CD) which is an autoimmune disease affecting 1% of the population is associated with other autoimmune diseases and has extraintestinal manifestations. In the present study, we investigated the demographic and laboratory data of 94 patients and diseases related to anemia, osteoporosis and other autoimmune diseases.
Material and Method: This study was conducted retrospectively by examining the records of 94 patients who were followed up with the diagnosis of CD between January 2014 and December 2019.
Results: Of the patients, 74 were female (79%), 20 were male (21%). The mean age of the patients was 35 (18-73). The average disease duration was 6.6 years (0-29). Anti-endomysium Ig A positivity in 81 patients (86%), tissue transglutaminase Ig A positivity in 87 patients (93%), and tissue transglutaminase IgG positivity in 45 patients (48%) were detected. 14 patients had hypothyroidism (15%) and 8 patients had diabetes mellitus (9%). Osteoporosis or osteopenia was detected in 61 patients as the result of bone mineral densitometry (65%). According to the ferritin results, half of the patients and according to the transferrin saturation result, 47% had iron deficiency. 13 patients had B12 deficiency (14%) and 24 patients had folic acid deficiency (26%). Vitamin D deficiency was found in 74% of the patients. TSH value was found over 4.5 mIU/L in 10 patients.
Conclusion: CD is associated with iron, folate, vitamin B12, and vitamin D deficiency and is associated with anemia and osteoporosis, and the disease is often accompanied by autoimmune thyroid diseases and diabetes.

Keywords

Celiac disease, hypothyroidism, osteoporosis, anemia

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