Estrogen in Luteal Phase Support: Effects on IVF-ICSI Antagonist Protocol Pregnancy Results

Year 2022, Volume: 12 Issue: 6, 978 - 983, 30.11.2022

Cemre Alan , Hüseyin Görkemli

https://doi.org/10.16899/jcm.1125489

Abstract

Aim: This study aimed to investigate the effect of luteal phase support (LPS) with estradiol in addition to progesterone on pregnancy outcomes in patients who underwent ovulation induction with GnRH antagonist protocol in in vitro fertilization- intracytoplasmic sperm injection (IVF-ICSI).
Materials and Methods: This retrospective study was carried out at reproductive medicine center of Necmettin Erbakan University Meram Medical Faculty. The study enrolled 128 patients undergoing ICSI on an antagonist protocol for controlled ovarian hyperstimulation. Study group administered 7.8 mg transdermal estradiol (E2) daily in addition to progesterone for LPS (n=64). Control group administered only progesterone for LPS (n=64). All women received 200 mg progesterone 3x1 intravaginal daily and 50 mg progesterone intramuscular injection per two days for LPS. Blood samples were drawn 12 days after embryo transfer for β-hCG. If the result is negative, treatment was discontinued, if positive, estradiol was discontinued and progesterone support was continued until the 10th week of gestation. Pregnancy outcomes were the main endpoint.
Results: There was no difference between groups in terms of biochemical pregnancy, clinical pregnancy, abortus and ongoing pregnancy rates.
Conclusion: In our study, the use of estrogen for luteal phase support in GnRH antagonist protocol did not show any difference on pregnancy outcomes.

Keywords

Luteal phase support, estradiol, GnRH antagonist, ICSI

Luteal Faz Desteğinde Östrojen: IVF-ICSI Antagonist Protokolde Gebelik Sonuçları Üzerine Etkisi

Abstract

Giriş: Bu çalışma GnRH antagonist protokolle IVF-ICSI yapılan hastalarda luteal faz desteğinde (LFD) progesterone ek olarak östradiol verilmesinin gebelik sonuçlarına etkisini incelemeyi amaçlamaktadır.
Gereç ve Yöntem: Bu retrospektif çalışma Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi Yardımla Üreme Teknikleri Merkezinde yapılmıştır. Çalışmaya GnRH antagonist protokolle kontrollü ovaryan stimülasyon uygulanacak 128 hasta katılmıştır. Çalışma grubuna LFD’de progesterona ek olarak günlük 7.8 mg transdermal estradiol (E2) uygulanmıştır (n=64). Kontrol grubu LFD için sadece progesteron kullanmıştır (n=64). Tüm kadınlara LFD’ de günlük 200 mg progesteron 3x1 intravajinal ve gün aşırı 50 mg progesteron intramuskuler uygulanmıştır. β-hCG için kan örnekleri embryo transferinden 12 gün sonra alınmıştır. Sonuç negatifse tedavi sonlandırılmış, pozitifse estradiol sonlandırılıp progesteron desteği gebeliğin 10. Haftasına kadar sürdürülmüştür. Gebelik sonuçları esas hedef olarak belirlenmiştir.
Bulgular: Gruplar arasında biyokimyasal gebelik, klinik gebelik, abortus ve devam eden gebelik oranları açısından fark bulunamadı.
Sonuç: Çalışmamızda GnRH antagonist protokol LFD’de östrojen kullanımı gebelik sonuçları üzerinde farklılık göstermedi.

Keywords

Luteal faz desteği, estradiol, GnRH antagonist, ICSI

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