Endoscopic Treatment of Postoperative Esophageal Anastomotic Strictures: A Single Center Experience
Year 2023,
Volume: 13 Issue: 4, 603 - 608, 31.07.2023
Muhammed Bahaddin Durak
,
Cem Şimşek
,
Zeki Mesut Yalın Kılıç
Abstract
Background
To evaluate the analysis, treatment methods and results of endoscopic treatments of esophagojejunostomy (EJ) and esophagogastric (EG) anastomotic strictures.
Methods:
Data from patients treated between 2009 and 2019 was collected and analyzed. The primary endpoint was defined as the absence of dysphagia for at least 6 months after the final endoscopic treatment session. The improvement in dysphagia scores at 1 and 6 months was accepted as the secondary endpoint.
Results
Of 18 patients (10 male), there were 11 patients with EG anastomotic stricture and 7 patients with EJ anastomotic stricture. Only balloon or bougie dilatation was applied to 13 patients, while 5 patients received a full-covered metal stent (FCMS) in addition to balloon or bougie dilatation due to persistent dysphagia symptoms. The primary endpoint was reached in 10 of the 13 patients (76.9%) who received only balloon or bougie dilatation. The secondary endpoint was reached in 3 patients. The primary endpoint was reached in 4 of the 5 patients (80%) who received a FCMS in addition to balloon or bougie dilatation. 6 patients (33.3%) had a recurrence. Major complications occurred in 4 (22.2%) patients, including perforation in 2 and stent migration in 2 patients.
Conclusion
The study demonstrated that endoscopic treatment of esophageal anastomotic strictures is a reliable and effective treatment option with a high success rate. The use of FCMS, either as a primary treatment option or in the treatment of perforation as a complication of endoscopic treatment, showed good effectiveness in our study.
Supporting Institution
None
References
- 1. Dryden GW, McClave SA. Methods of treating dysphagia caused by benign esophageal strictures. Tech Gastrointest Endosc 2001;3: 135-43
- 2. Kumbum K, Talavera F, Anand BS et al. Esophageal Stenosis. medscape 20 August 2019.
- 3. Honkoop P, Siersema PD, Tilanus HW, Stassen LP, Hop WC, van Blankenstein M. Benign anastomotic strictures after transhiatal esophagectomy and cervical esophagogastrostomy: risk factors and management. J Thorac Cardiovasc Surg. 1996; 111 (6):1141–1146.
- 4. Siddiqui UD, Banerjee S, Barth B, et al. Tools for endoscopic stricture dilatation. Gastrointest Endosc 2013;78:391–404
- 5. Wadhwa RP, Kozarek RA, France RE, et al. Use of self-expanding metallic stents in benign gastrointestinal diseases. Gastrointestinal Endosc. 2003;58(2):207–12
- 6. Chiu YC, Hsu CC, Chiu KW et al. Factors affecting clinical applications of endoscopic balloon dilation for benign esophageal strictures. Endoscopy 2004;36:595–600.
- 7. Saeed ZA, Ramirez FC, Hepps KS et al. An objective endpoint for dilation improves outcome of peptic esophageal strictures: a prospective, randomized trial. Gastrointest Endosc 1997;45:354–9.
- 8. Sami S, Haboubi HN, Yeng A et al. UK guidelines for esophageal dilatation in clinical practice: British Society of Gastroenterology (BSG) Clinical Guidelines. gutjnl-2017-315414
- 9. Kochman ML, McClave SA, Boyce HW. Resistant and recurrent esophageal stricture: a definition. Gastrointest Endosc 2005;62:474-5.
- 10. Siersema Police. Treatment options for esophageal strictures. Nat Clin Pract Gastroenterol Hepatol. 2008;5(3):142–52.
- 11. Lu, Q., Yan, H., Wang, Y. et al. The role of endoscopic dilatation and stents in resistant benign esophageal strictures: a retrospective analysis. BMC Gastroenterol 2019;19:95.
- 12. Lee J, Song HY, Ko HK et al. Fluoroscopy-guided balloon dilation or temporary stent placement in patients with gastric conduit strictures after esophagogastrostomy and esophagectomy. AJR Am J Roentgenol 2013;201:202–7.
- 13. Fuccio L, Hassan C, Frazzoni L, Miglio R, Repici A. Clinical outcomes following stent placement in resistant benign esophageal stricture: a systematic review and meta-analysis. Endoscopy. 2016;48(2):141-8
- 14. van Hooft JE, van Berge Henegouwen MI, Rauws EA, et al. Endoscopic treatment of benign anastomotic esophagogastric strictures with a biodegradable stent. Gastrointestinal Endosc. 2011;73(5):1043-7. 17.
- 15. Poincloux L, Rouquette O, Abergel A. Endoscopic treatment of benign esophageal strictures: a literature review. Expert Rev Gastroenterol Hepatol. 2017;11(1):53-64.
- 16. Park JY, Song HY, Kim JH and others. Benign anastomotic strictures after esophagectomy: long-term efficacy of balloon dilatation in 155 patients and factors affecting recurrence. AJR AmJ Roentgenol. 2012;198(5):1208-13.
- 17. Saxena P, Khashab MA. Endoscopic Management of Esophageal Perforations: Who, When and How? Curr Treatment Options Gastroenterol. 2017;15(1):35-45.
Postoperatif Özofageal Anastomoz Darlıklarının Endoskopik Tedavisi: Tek Merkez Deneyimi
Year 2023,
Volume: 13 Issue: 4, 603 - 608, 31.07.2023
Muhammed Bahaddin Durak
,
Cem Şimşek
,
Zeki Mesut Yalın Kılıç
Abstract
Giriş
Özofagojejunostomi ve özofagogastrik anastomoz darlıklarının endoskopik tedavilerinin analizi, tedavi yöntemleri ve sonuçlarının değerlendirilmesi.
Yöntem
2009 ve 2019 yılları arasında endoskopik olarak tedavi edilen hastaların verileri toplandı ve analiz edildi. Primer sonlanım noktası, son endoskopik tedavi seansından sonra en az 6 ay süreyle disfaji olmaması olarak tanımlandı. 1. ve 6. aylarda disfaji skorlarındaki iyileşme ikincil sonlanım noktası olarak kabul edildi.
Sonuçlar
18 hastanın (10 erkek) 11'inde özofagogastrik anastomoz darlığı, 7'sinde Özofagojejunostomi anastomoz darlığı vardı. 13 hastaya sadece balon veya buji dilatasyonu uygulanırken, 5 hastaya devam eden disfaji semptomları nedeniyle balon veya buji dilatasyonuna ek olarak tam kaplı metal stent uygulandı. Sadece balon veya buji dilatasyonu uygulanan 13 hastanın 10'unda (%76.9) primer sonlanım noktasına ulaşıldı. İkincil sonlanım noktasına 3 hastada ulaşıldı. Balon veya buji dilatasyonuna ek olarak tam kaplı metal stent uygulanan 5 hastanın 4'ünde (%80) primer sonlanım noktasına ulaşıldı. 6 hastada (%33.3) nüks görüldü. 2 hastada perforasyon ve 2 hastada stent migrasyonu olmak üzere 4 (%22,2) hastada majör komplikasyon gelişti.
Sonuç
Çalışmamız, özofagus anastomoz darlıklarının endoskopik tedavisinin yüksek başarı oranı ile güvenilir ve etkili bir tedavi seçeneği olduğunu göstermiştir. Tam kaplı metal stentin hem primer tedavi seçeneği olarak hem de endoskopik tedavinin bir komplikasyonu olarak perforasyon tedavisinde kullanılması çalışmamızda iyi etkinlik göstermiştir.
References
- 1. Dryden GW, McClave SA. Methods of treating dysphagia caused by benign esophageal strictures. Tech Gastrointest Endosc 2001;3: 135-43
- 2. Kumbum K, Talavera F, Anand BS et al. Esophageal Stenosis. medscape 20 August 2019.
- 3. Honkoop P, Siersema PD, Tilanus HW, Stassen LP, Hop WC, van Blankenstein M. Benign anastomotic strictures after transhiatal esophagectomy and cervical esophagogastrostomy: risk factors and management. J Thorac Cardiovasc Surg. 1996; 111 (6):1141–1146.
- 4. Siddiqui UD, Banerjee S, Barth B, et al. Tools for endoscopic stricture dilatation. Gastrointest Endosc 2013;78:391–404
- 5. Wadhwa RP, Kozarek RA, France RE, et al. Use of self-expanding metallic stents in benign gastrointestinal diseases. Gastrointestinal Endosc. 2003;58(2):207–12
- 6. Chiu YC, Hsu CC, Chiu KW et al. Factors affecting clinical applications of endoscopic balloon dilation for benign esophageal strictures. Endoscopy 2004;36:595–600.
- 7. Saeed ZA, Ramirez FC, Hepps KS et al. An objective endpoint for dilation improves outcome of peptic esophageal strictures: a prospective, randomized trial. Gastrointest Endosc 1997;45:354–9.
- 8. Sami S, Haboubi HN, Yeng A et al. UK guidelines for esophageal dilatation in clinical practice: British Society of Gastroenterology (BSG) Clinical Guidelines. gutjnl-2017-315414
- 9. Kochman ML, McClave SA, Boyce HW. Resistant and recurrent esophageal stricture: a definition. Gastrointest Endosc 2005;62:474-5.
- 10. Siersema Police. Treatment options for esophageal strictures. Nat Clin Pract Gastroenterol Hepatol. 2008;5(3):142–52.
- 11. Lu, Q., Yan, H., Wang, Y. et al. The role of endoscopic dilatation and stents in resistant benign esophageal strictures: a retrospective analysis. BMC Gastroenterol 2019;19:95.
- 12. Lee J, Song HY, Ko HK et al. Fluoroscopy-guided balloon dilation or temporary stent placement in patients with gastric conduit strictures after esophagogastrostomy and esophagectomy. AJR Am J Roentgenol 2013;201:202–7.
- 13. Fuccio L, Hassan C, Frazzoni L, Miglio R, Repici A. Clinical outcomes following stent placement in resistant benign esophageal stricture: a systematic review and meta-analysis. Endoscopy. 2016;48(2):141-8
- 14. van Hooft JE, van Berge Henegouwen MI, Rauws EA, et al. Endoscopic treatment of benign anastomotic esophagogastric strictures with a biodegradable stent. Gastrointestinal Endosc. 2011;73(5):1043-7. 17.
- 15. Poincloux L, Rouquette O, Abergel A. Endoscopic treatment of benign esophageal strictures: a literature review. Expert Rev Gastroenterol Hepatol. 2017;11(1):53-64.
- 16. Park JY, Song HY, Kim JH and others. Benign anastomotic strictures after esophagectomy: long-term efficacy of balloon dilatation in 155 patients and factors affecting recurrence. AJR AmJ Roentgenol. 2012;198(5):1208-13.
- 17. Saxena P, Khashab MA. Endoscopic Management of Esophageal Perforations: Who, When and How? Curr Treatment Options Gastroenterol. 2017;15(1):35-45.