Relationship Between Prolonged Jaundice and Vitamin B12 Levels in Term Newborn

Year 2023, Volume: 13 Issue: 4, 671 - 675, 31.07.2023

Emine Esin Yalınbaş , Yaşar Durmaz , Fezan Mutlu

https://doi.org/10.16899/jcm.1309898

Abstract

Abstract
Aim: Vitamin B12 deficiency, when observed during the neonatal period, can generally be traced back to maternal causes. In cases of vitamin B12 deficiency, hyperbilirubinemia may occur due to hem overproduction as the result of erythrocyte lysis. Prolonged jaundice is common during the neonatal period, and its underlying etiological causes should be analyzed. The aim of this study was to analyze whether vitamin B12 deficiency has any effect on prolonged jaundice formation in infants.
Material and Method: The study examined 89 infants; this included 45 that had been diagnosed with prolonged jaundice and 44 in the control group. Their clinical and demographic characteristics were recorded. Patient group was formed with term infants with prolonged jaundice excluding possible etiological causes of prolonged jaundice. Both the maternal and infant vitamin B12 levels were analyzed.
Results:An indirect bilirubin level of 11.8 mg/dl in the prolonged jaundice group and 3.16 mg/dl (p < 0.001), a hemoglobin level of 14.18 gr/dl and 15.7 gr/dl (p = 0.005), and infant vitamin B12 level of 168 pg/ml and 205.2 pg/ml (p=0.013) in the patient and control groups, respectively, showed significant differences between the two. Maternal vitamin B12 levels were found to be similar in the patient and control groups (p= 0.315), and there was no significant correlation between the vitamin B12 levels of the infants and mothers (r = 0.278, p = 0.064).
Conclusion: Vitamin B12 deficiency can be related to prolonged jaundice in neonatals, and an early diagnosis of vitamin B12 deficiency in high risks group in the neonatal period can be useful in terms of potentially identifying and controlling related conditions.
Keywords: Jaundice, newborn, vitamin B12 deficiency

Keywords

Jaundice, newborn, vitamin B12 deficiency

Supporting Institution

none

Project Number

none

Term Yenidoğanlarda Uzamış Sarılık ile Vitamin B12 Düzeyleri Arasındaki İlişki

Abstract

Özet
Amaç: Yenidoğan döneminde görülen vitamin B12 eksikliği genellikle maternal nedenlerle ilişkilidir. Vitamin B12 eksikliğinde yenidoğan döneminde eritrosit lizisi sonucunda aşırı hem üretimine bağlı hiperbilirubinemi gelişebilmektedir Uzamış sarılık ise yenidoğan döneminde yaygın görülen bir durumdur, allta yatan etiyolojik nedenler araştırılmalıdır. Bu çalışmanın amacı, bebeklerde uzamış sarılık gelişiminde vitamin B12 eksikliğinin etkisinin olup olmadığını araştırmaktır.
Gereç ve Yöntem : 45 uzamış sarılık tanısı alan yenidoğan ile 44 kontrol grubunun yer aldığı toplam 89 bebek çalışmaya dahil edildi. Klinik ve demografik özellikleri kaydedildi. Hasta grubu uzamış sarılığa neden olabilecek etiyolojik nedenler dışlanmış, uzamış sarılığı olan term bebeklerden oluşturuldu. Anne ve bebeklerden vit B12 düzeyleri ile çalışıldı.
Bulgular: Uzamış sarılık grubunda indirekt bilirubin düzeyi 11.8 mg/dl, kontrol grubunda 3.16 mg/dl (p< 0.001), hemoglobin düzeyi hasta grubunda 14.18 gr/dl, kontrol grubunda 15.7 gr/dl (p= 0.005), bebek vitamin B12 düzeyleri hasta grubunda 168 pg/ml (p= 0.013) olmak üzere kontrol grubuna 205.2 pg/ml (p=0.013) göre anlamlı farklılık vardı. Anne vitamin B12 düzeyleri hasta ve kontrol grubunda benzer bulundu (p= 0.315). Bebek ve annelerden bakılan vitamin B12 düzeyleri arasında anlamlı bir korelasyon olmadığı saptandı (r= 0.278, P= 0.064). Sonuç: Yenidoğanlarda vitamin B12 eksikliğinin uzamış sarılık ile ilişkili olabileceği ve yenidoğan döneminde riskli grupta erken konulan vitamin B12 eksikliği tanısının buna bağlı gelişebilecek durumların kontrol altına alınmasında fayda sağlayabileceğini düşünmekteyiz

Keywords

Sarılık, yenidoğan, vitamin B12 eksikliği

Project Number

none

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