Abstract
References
- Albers DS, Augood SJ, Martin DM, Standaert DG, Vonsattel JP, Beal MF. 1999. Evidence for oxidative stress in the subthalamic nucleus in progressive supranuclear palsy. J Neurochem. Aug, 73(2): 881-4. Amir M, Dhar N and Tiwari SK. 1997. Synthesis and Anti-inflammatory Activity of Some New Indole and Indazole Derivatives. Indian. J. Chem. Sect B. 36: 96-98. Amorim EL, Brandao SS, Cavalcanti CO, Galdino SL, Pitta IR and Luu-Duc C. 1992. Synthesis and structure of substituted bromo and nitrobenzyl benzylidene imidazolidinediones and thiazolidinediones. Ann. Pharm. Fr. 50(2): 103-111.
Effects of The Hydroxyurea Derivative 1, 3 ,4 - Thiadiazoles on Antioxidant Vitamins and MDA in Serums of Rats and Cell Viability of MCF-7 Breast Cancer Cells
Abstract
In this study, the effects of as used
ligand [1-hydroxy - 2 - (5 - (trifluoromethyl) - 1, 3, 4- thiadiazole- 2 - yl) guanidine]
and its Mn, Cd, Cr complexes on the antioxidant vitamins and MDA levels in the
serums of rats and antitumor activity of these chemical compounds on the MCF-7
breast cancer cells at different concentrations were investigated. When the
results were compared between the levels of control and experimental groups of
antioxidant vitamins and MDA statistically, it was observed that there were
decreased levels of A, E, and C vitamins in groups of applied Cd (II) and Cr
(II) complexes compared with the control group,
whereas MDA levels were increased. The antioxidant vitamins and MDA
levels in serum were determined by HPLC. It was clearly observed that the
subcutaneously MCF-7 breast cancer cells treated Ligand (L), Mn (L) 2, Cd (L) 2
and Cr (L) 2 complexes had the low levels of cell viability activity when
compared to the untreated control cells clearly increased according to the
control group for after incubation 24 h onwards to 48 h. Cell vialities
measured by electronic microscope. As a result, it suggested that thiadiazole
compounds exhibit antitumor activity with reduction in serum antioxidant
vitamins of rats can cause cytotoxic effect depending on the mechanism of
oxidative damage.
Keywords
References
- Albers DS, Augood SJ, Martin DM, Standaert DG, Vonsattel JP, Beal MF. 1999. Evidence for oxidative stress in the subthalamic nucleus in progressive supranuclear palsy. J Neurochem. Aug, 73(2): 881-4. Amir M, Dhar N and Tiwari SK. 1997. Synthesis and Anti-inflammatory Activity of Some New Indole and Indazole Derivatives. Indian. J. Chem. Sect B. 36: 96-98. Amorim EL, Brandao SS, Cavalcanti CO, Galdino SL, Pitta IR and Luu-Duc C. 1992. Synthesis and structure of substituted bromo and nitrobenzyl benzylidene imidazolidinediones and thiazolidinediones. Ann. Pharm. Fr. 50(2): 103-111.
Details
| Primary Language | English |
|---|---|
| Journal Section | Original Articles |
| Authors | |
| Publication Date | September 1, 2015 |
| Published in Issue | Year 2015 |