Case Report
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Death Due to Furosemide Anaphylaxis and The Importance of Serum Tryptase Level in Diagnosing Anaphylaxis: A Case Report

Year 2024, , 7 - 9, 29.03.2024
https://doi.org/10.33706/jemcr.1338799

Abstract

Anaphylaxis is a severe systemic hypersensitivity reaction with a sudden onset and may result in death. In this study, we report the case of a 71-year-old female patient who died within seconds after the administration of intravenous furosemide in emergency service; she had high serum tryptase levels at postmortem examination and nonspecific findings at autopsy, and death due to anaphylaxis was reported. With this study, we wanted to point to the rare and potentially fatal drug anaphylaxis, such as furosemide anaphylaxis. Also, our results indicate the importance of serum tryptase levels in the diagnosis of death due to anaphylaxis.

References

  • 1. Muñoz-Cano R, Picado C, Valero A, Bartra J. Mechanisms of Anaphylaxis Beyond IgE. J InvestigAllergolClinImmunol. 2016;26:73-82.
  • 2. Simons FER, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, et al. 2015 update of the evidencebase: World AllergyOrganizationanaphylaxisguidelines. World Allergy Organ J. 2015;8:32.
  • 3. Hansbrough JR, Wedner HJ, Chaplin DD. Anaphylaxis to intravenousfurosemide. J AllergyClinImmunol. 1987;80:538-41.
  • 4. Domínguez-Ortega J, Martínez-Alonso JC, Domínguez-Ortega C, Fuentes MJ, Frades A, Fernández-Colino T. Anaphylaxis to oral furosemide. AllergolImmunopathol (Madr). 2003;31:345-7. 5. Machtey I. Sudden death afterintramuscularfrusemide. Lancet. 1968;2:1301.
  • 6. Osborn, M, Chambers, D, Parcq, J, et al. Guidelines on autopsy practice: Autopsy for suspected acute anaphylaxis (includes anaphylactic shock and anaphylactic asthma). R. Coll. Pathol. 2018;1–12
  • 7. Schwartz LB. Diagnostic Value of Tryptase in Anaphylaxis and Mastocytosis. C. 26, Immunology and AllergyClinics of North America. ImmunolAllergyClin North Am; 2006;26:451-63.
  • 8. Passia E, Jandus P. Using Baseline and Peak Serum Tryptase Levels to DiagnoseAnaphylaxis: a Review. ClinRevAllergyImmunol. 2020;58:366-76.
  • 9. Valent P, Akin C, Arock M, Brockow K, Butterfield JH, Carter MC, et al. Definitions, criteria and global classification of mastcelldisorders with specialreference to mastcellactivationsyndromes: a consensusproposal. IntArchAllergyImmunol. 2012;157:215-25.
  • 10. Tse R, Wong CX, Kesha K, Garland J, Tran Y, Anne S, et al. Post-mortem tryptase cut-offlevelforanaphylactic death. Forensic SciInt. 2018;284:5-8.
  • 11. Turner PJ, Jerschow E, Umasunthar T, Lin R, CampbellDE,Boyle RJ. FatalAnaphylaxis: Mortality Rate and Risk Factors. J AllergyClinImmunolPract. 2017;5:1169-78.
  • 12. Xiao N, Li DR, Wang Q, Zhang F, Yu YG, Wang HJ. Postmortem Serum Tryptase Levels with Special Regard to AcuteCardiacDeaths. J Forensic Sci. Eylül 2017;62:1336-8.
  • 13. Kervinen H, Kaartinen M, Mäkynen H, Palosuo T, Mänttäri M, Kovanen PT. Serum tryptase levels in acutecoronarysyndromes. Int J Cardiol. 2005;104:138-43.
  • 14. Orhan F, Civelek E, Şahiner ÜM, Arga M, Can D, Çalıkaner AZ, et al. Anaphylaxis: TurkishNationalGuideline 2018. AsthmaAllergyImmunol 2018; 16 (Suppl 1):1-62.
Year 2024, , 7 - 9, 29.03.2024
https://doi.org/10.33706/jemcr.1338799

Abstract

References

  • 1. Muñoz-Cano R, Picado C, Valero A, Bartra J. Mechanisms of Anaphylaxis Beyond IgE. J InvestigAllergolClinImmunol. 2016;26:73-82.
  • 2. Simons FER, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, et al. 2015 update of the evidencebase: World AllergyOrganizationanaphylaxisguidelines. World Allergy Organ J. 2015;8:32.
  • 3. Hansbrough JR, Wedner HJ, Chaplin DD. Anaphylaxis to intravenousfurosemide. J AllergyClinImmunol. 1987;80:538-41.
  • 4. Domínguez-Ortega J, Martínez-Alonso JC, Domínguez-Ortega C, Fuentes MJ, Frades A, Fernández-Colino T. Anaphylaxis to oral furosemide. AllergolImmunopathol (Madr). 2003;31:345-7. 5. Machtey I. Sudden death afterintramuscularfrusemide. Lancet. 1968;2:1301.
  • 6. Osborn, M, Chambers, D, Parcq, J, et al. Guidelines on autopsy practice: Autopsy for suspected acute anaphylaxis (includes anaphylactic shock and anaphylactic asthma). R. Coll. Pathol. 2018;1–12
  • 7. Schwartz LB. Diagnostic Value of Tryptase in Anaphylaxis and Mastocytosis. C. 26, Immunology and AllergyClinics of North America. ImmunolAllergyClin North Am; 2006;26:451-63.
  • 8. Passia E, Jandus P. Using Baseline and Peak Serum Tryptase Levels to DiagnoseAnaphylaxis: a Review. ClinRevAllergyImmunol. 2020;58:366-76.
  • 9. Valent P, Akin C, Arock M, Brockow K, Butterfield JH, Carter MC, et al. Definitions, criteria and global classification of mastcelldisorders with specialreference to mastcellactivationsyndromes: a consensusproposal. IntArchAllergyImmunol. 2012;157:215-25.
  • 10. Tse R, Wong CX, Kesha K, Garland J, Tran Y, Anne S, et al. Post-mortem tryptase cut-offlevelforanaphylactic death. Forensic SciInt. 2018;284:5-8.
  • 11. Turner PJ, Jerschow E, Umasunthar T, Lin R, CampbellDE,Boyle RJ. FatalAnaphylaxis: Mortality Rate and Risk Factors. J AllergyClinImmunolPract. 2017;5:1169-78.
  • 12. Xiao N, Li DR, Wang Q, Zhang F, Yu YG, Wang HJ. Postmortem Serum Tryptase Levels with Special Regard to AcuteCardiacDeaths. J Forensic Sci. Eylül 2017;62:1336-8.
  • 13. Kervinen H, Kaartinen M, Mäkynen H, Palosuo T, Mänttäri M, Kovanen PT. Serum tryptase levels in acutecoronarysyndromes. Int J Cardiol. 2005;104:138-43.
  • 14. Orhan F, Civelek E, Şahiner ÜM, Arga M, Can D, Çalıkaner AZ, et al. Anaphylaxis: TurkishNationalGuideline 2018. AsthmaAllergyImmunol 2018; 16 (Suppl 1):1-62.
There are 13 citations in total.

Details

Primary Language English
Subjects Emergency Medicine, Forensic Medicine
Journal Section Case Report
Authors

Soner Dağlı 0000-0003-2073-4872

Mustafa Talip Şener 0000-0002-1295-7710

Ahmet Nezih Kök 0000-0001-5022-9119

Ahmet Şahpaz 0000-0001-8719-436X

Publication Date March 29, 2024
Submission Date August 7, 2023
Published in Issue Year 2024

Cite

APA Dağlı, S., Şener, M. T., Kök, A. N., Şahpaz, A. (2024). Death Due to Furosemide Anaphylaxis and The Importance of Serum Tryptase Level in Diagnosing Anaphylaxis: A Case Report. Journal of Emergency Medicine Case Reports, 15(1), 7-9. https://doi.org/10.33706/jemcr.1338799
AMA Dağlı S, Şener MT, Kök AN, Şahpaz A. Death Due to Furosemide Anaphylaxis and The Importance of Serum Tryptase Level in Diagnosing Anaphylaxis: A Case Report. Journal of Emergency Medicine Case Reports. March 2024;15(1):7-9. doi:10.33706/jemcr.1338799
Chicago Dağlı, Soner, Mustafa Talip Şener, Ahmet Nezih Kök, and Ahmet Şahpaz. “Death Due to Furosemide Anaphylaxis and The Importance of Serum Tryptase Level in Diagnosing Anaphylaxis: A Case Report”. Journal of Emergency Medicine Case Reports 15, no. 1 (March 2024): 7-9. https://doi.org/10.33706/jemcr.1338799.
EndNote Dağlı S, Şener MT, Kök AN, Şahpaz A (March 1, 2024) Death Due to Furosemide Anaphylaxis and The Importance of Serum Tryptase Level in Diagnosing Anaphylaxis: A Case Report. Journal of Emergency Medicine Case Reports 15 1 7–9.
IEEE S. Dağlı, M. T. Şener, A. N. Kök, and A. Şahpaz, “Death Due to Furosemide Anaphylaxis and The Importance of Serum Tryptase Level in Diagnosing Anaphylaxis: A Case Report”, Journal of Emergency Medicine Case Reports, vol. 15, no. 1, pp. 7–9, 2024, doi: 10.33706/jemcr.1338799.
ISNAD Dağlı, Soner et al. “Death Due to Furosemide Anaphylaxis and The Importance of Serum Tryptase Level in Diagnosing Anaphylaxis: A Case Report”. Journal of Emergency Medicine Case Reports 15/1 (March 2024), 7-9. https://doi.org/10.33706/jemcr.1338799.
JAMA Dağlı S, Şener MT, Kök AN, Şahpaz A. Death Due to Furosemide Anaphylaxis and The Importance of Serum Tryptase Level in Diagnosing Anaphylaxis: A Case Report. Journal of Emergency Medicine Case Reports. 2024;15:7–9.
MLA Dağlı, Soner et al. “Death Due to Furosemide Anaphylaxis and The Importance of Serum Tryptase Level in Diagnosing Anaphylaxis: A Case Report”. Journal of Emergency Medicine Case Reports, vol. 15, no. 1, 2024, pp. 7-9, doi:10.33706/jemcr.1338799.
Vancouver Dağlı S, Şener MT, Kök AN, Şahpaz A. Death Due to Furosemide Anaphylaxis and The Importance of Serum Tryptase Level in Diagnosing Anaphylaxis: A Case Report. Journal of Emergency Medicine Case Reports. 2024;15(1):7-9.