CLINICAL COURSE OF A DEATH FROM RANOLAZINE OVERDOSE: A CASE REPORT

Year 2020, , 35 - 38, 09.10.2020

Mehmet Ali Yavuz , Ramazan Asoglu

https://doi.org/10.33706/jemcr.607486

Cited By: 2

Abstract

Introduction: Ranolazine is a new medication for angina
pectoris. It is usually used for refractory angina pectoris. Ranolazine
overdose may cause some serious effects on heart like other cardiac medications.

Case Report: We report the case of a 21-year-old girl
was brought to the emergency department because of an attempt to commit suicide
with a large number of Ranolazine tablets. She went into the coma and was
unresponsive to verbal and painful stimuli after two hours of admission. There
was no pathological findings on brain computed tomography (CT) and Magnetic
Resonance Imaging (MRI). The QT interval was 420 msec and more extended than
previous measurements. The patient had three episodes of polymorphic
nonsustained ventricular tachycardia (NSVT). Despite the amiodarone treatment,
the NSVT evolved to polymorphic sustained ventricular tachycardia (Torsade de
Pointes; TdP) and Ventricular fibrillation (VF). The patient underwent CPR and
accepted as death end of the resuscitation due to asystole on the ECG.

Conclusion: Ranolazine overdose is known that may cause
some serious ECG changes and seizures. But suddenly entering a coma and death
has never been reported with ranolazine intoxication in literature.

Keywords

Ranolazine overdose, Death, Torsades De Pointes

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