Hematopoietik kök hücre nakli uygulanan bireylerde nakil tipine göre kas kuvveti, ağrı, yorgunluk ve fiziksel aktivite düzeylerinin incelenmesi

Year 2021, Volume: 8 Issue: 3, 238 - 244, 31.12.2021

Vesile Yıldız Kabak , Songul Atasavun Uysal , Elifcan Aladağ , Hakan Goker Tülin Düger

https://doi.org/10.15437/jetr.949940

Abstract

Amaç: Çalışmamızın amacı, hematopoietik kök hücre nakli (HKHN) tedavisi uygulanan bireylerde nakil tipine göre kas kuvveti, ağrı, yorgunluk ve fiziksel aktivite düzeyini araştırmaktı.

Yöntem: Çalışmamıza HKHN ile tedavi olmuş ve en az 3 ay geçmiş toplam 61 birey dahil edildi. Ağrı ve yorgunluk düzeyi Vizuel Analog Skalası ile değerlendirildi. Katılımcıların kavrama kuvveti ve periferal kas kuvveti skorları dinamometre ile ölçüldü. 30-saniye Otur-Kalk Testi fonksiyonel performansı değerlendirmede kullanıldı. Uluslararası Fiziksel Aktivite Anketi, fiziksel aktivite düzeyini ölçmede kullanıldı.

Bulgular: Bireyler nakil tipine göre otolog (n=30) ve allojenik (n=31) olarak iki gruba ayrıldı. Katılımcıların tanısı dışında gruplar arasında demografik ve medikal karakteristikler açısından anlamlı bir fark yoktu (p˃0,05). Gruplar arasında kaydedilen sonuç ölçümleri karşılaştırıldığında; allojenik HKHN uygulanan bireylerin otolog HKHN uygulanan bireylere göre anlamlı ölçüde daha yüksek yorgunluğu var iken (p=0,027); Quadriceps femoris kas kuvveti (p=0,042) ve 30-saniye Otur-Kalk Testi sonuçları (p=0,006) anlamlı ölçüde daha düşüktü. Gruplar arasında diğer kaydedilen sonuç ölçümleri açısından anlamlı bir farklılık yoktu (p˃0,05).

Sonuç: Allojenik HKHN uygulanan bireyler otolog HKHN uygulanan bireylere göre daha fazla fiziksel problemlere sahiptir. Fizyoterapistler, nakil tipinin hastanın fonksiyonel defisitlerini artırabileceğinin farkında olup egzersiz programlarını nakil tipine göre ayarlayarak kişilerin en erken seviyede toparlanmalarına destek olmalıdırlar.

Keywords

kök hücre nakli, kas kuvveti, fiziksel aktivite, Ağrı, Yorgunluk

Investigation of muscle strength, pain, fatigue, and physical activity levels by transplant type in individuals undergoing hematopoietic stem cell transplantation

Abstract

Purpose: The aim of the present study was to investigate muscle strength, pain, fatigue, and physical activity level in terms of transplantation type in individuals undergoing hematopoietic stem cell transplantation (HSCT).

Methods: A total of 61 indiviuals treated with HSCT at least 3 months ago were included in this study. Pain and fatigue level was assessed by using the Visual Analogue Scale. Grip strength and peripheral muscle strength of the participants were assessed by using dynamometer. The 30-second Sit to Stand Test was used to assess functional performance. The International Physical Activity Questionnaire was used to measure physical activity level.

Results: Individuals were assigned to two groups as autologous (n=30) and allogeneic (n=31) according to the transplantation type. There was no significant difference in terms of demographic and medical characteristics except for diagnosis participants between the groups (p˃0.05). When compared the recorded outcomes between the groups; patients treated with allogenic HSCT had significantly higher fatigue level (p=0.027), while significanly lower quadriceps femoris muscle strength (p=0.042) and the 30-second Sit to Stand test score (p=0.006) than patients treated with autologous HSCT. There was no significant difference between the groups in terms of the other recorded outcomes (p˃0.05).

Conclusion: Individuals treated with allogeneic HSCT have higher physical problems than individuals treated with autologous HSCT. Physiotherapist should consider that transplantation type may increase functional deficits and they should should support the recovery of people at the earliest phase by adjust exercise program according to the transplantation type.

Keywords

stem cell transplantation, Muscle strength, Physical activity, Pain, Fatigue.

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