FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION

Year 2020, Volume: 44 Issue: 1, 33 - 49, 31.01.2020

Neslihan Üstündağ Okur , Vildan Yozgatlı Zeynep Şenyiğit

https://doi.org/10.33483/jfpau.586590

Cited By: 5

Abstract

Objective: This study
was aimed to prepare, characterize and evaluate in situ gel formulation for a
sustained ocular delivery of voriconazole.

Material and Method: In situ gels
were prepared with three different hydrophilic co-polymers: Poloxamer 188, 407
and 388. The formulations were characterized in terms of their clarity, pH,
viscosity drug content uniformity and mechanical/rheological properties.
Moreover, in vitro drug release and stabilitystudies were performed.

Result
and Discussion: The results showed that the optimized in situ
gel formulation had desired in vitro properties and a good stability over the
period of 3 months. Texture profile analysis presented that formulations
offered suitable adhesive and mechanical properties. P2-V formulation exhibited
pseudo-plastic flow and typical gel-type mechanical spectra (G′ > G″) at
different frequecy values and at different temperatures. Moreover, all
formulations showed a sustained drug release for 24 hours. In conclusion,
voriconazole loaded in situ gel could be offered as an encouraging strategy as
ocular systems for ocular infections treatment.

Keywords

mechanical properties poloxamer, rheological properties, thermo-sensitive in situ gel

Thanks

The authors would like to thank to the BASF for providing the poloxamers.

OKÜLER UYGULAMA İÇİN VORİKONAZOL YÜKLÜ İN SİTU JELLERİN FORMÜLASYONU VE DETAYLI KARAKTERİZASYONU

Abstract

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