COVID-19 TEDAVİSİNDE İLAÇ-İLAÇ ETKİLEŞİMLERİNİN FARMAKOKİNETİK AÇIDAN DEĞERLENDİRİLMESİ

Year 2021, Volume: 45 Issue: 2, 443 - 456, 31.05.2021

Nuran Coşkun Ozge Ulker

https://doi.org/10.33483/jfpau.881317

Abstract

Amaç: Çin'in Wuhan kentinde başlayan ve tüm dünyayı etkileyen COVID-19 pandemisi, bulaşıcılığı ve ölümcüllüğü benzersiz bir küresel mücadeleyi hala temsil etmektedir. COVID-19 hastalarının semptomları, hastalığın ciddiyetine göre farklılık gösterebilmektedir. Sağlık Bakanlığı Koronavirüs Araştırma Danışma Kurulu, COVID-19'un teşhisi, tedavisi ve kontrolü hakkında yayınladığı rapora göre ilaç kombinasyon tedavisi (hidroksiklorokin, lopinavir / ritonavir ve favipiravir) sağlık yetkilileri tarafından önerilmektedir. Çoğunlukla karaciğerde bulunan sitokrom P 450 enzimleri (CYP) tarafından metabolize edilen bu ilaçların diğer bazı ilaçlarla eş zamanlı kullanımları sonucu ilaç-ilaç etkileşimi olası bir durumdur. Biz bu derlemede COVID-19 tedavisinde kullanılan ilaçların özellikle metabolizma yolaklarını da belirterek farmakokinetik olarak ilaç-ilaç etkileşmelerini göstermeyi amaçladık.

Sonuç ve Tartışma: COVID-19 pandemisi dünya çapında sosyal hayatı, ekonomik ve finansal piyasaları olumsuz etkilemektedir. Uygun tedavi protokolleri büyük önem taşımaktadır. Ancak tedavi uygulamalarında ilaç-ilaç etkileşimlerinin göz önünde bulundurulması, hasta tedavisinde istenmeyen sonuçların oluşmasına engel olur.

Keywords

COVID 19, ilaç-ilaç etkileşmeleri, farmakokinetik, CYP enzimleri

PHARMACOKINETIC EVALUATION OF DRUG-DRUG INTERACTIONS IN THE TREATMENT OF COVID-19

Abstract

Objective: The COVID-19 pandemic, which started in Wuhan, China and affected the whole world, still represents a unique global challenge with its contagiousness and lethality. The symptoms of COVID-19 patients may differ depending on the severity of the disease. According to the report published by the Ministry of Health Coronavirus Research Advisory Board on the diagnosis, treatment and control of COVID-19, drug combination therapy (hydroxychloroquine, lopinavir / ritonavir and favipiravir) is recommended by health

authorities. Drug-drug interaction is a possible situation as a result of simultaneous use of these drugs, which are metabolized by cytochrome P 450 enzymes (CYP), which are mostly found in the liver, with some other drugs. In this review, we aimed to show the pharmacokinetic drug-drug interactions of the drugs used in the treatment of COVID-19, especially by indicating the metabolism pathways.

Result and Discussion: The COVID-19 pandemic adversely affects social life, economic and financial markets worldwide. Appropriate treatment protocols are of great importance but taking drug-drug interactions into account in treatment practices prevents unwanted results in patient treatment.

Keywords

COVID-19, drug-drug interactions, pharmacokinetic, CYP enzymes

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