REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ

Nazlı Turan Yücel; Ümmühan Kandemir; Umut İrfan Üçel; Özgür Devrim Can; Ümide Demir Özkay

doi:10.33483/jfpau.1149796

Research Article

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REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ

Year 2023, Volume: 47 Issue: 1, 20 - 38, 20.01.2023

Nazlı Turan Yücel , Ümmühan Kandemir , Umut İrfan Üçel , Özgür Devrim Can , Ümide Demir Özkay

https://doi.org/10.33483/jfpau.1149796

Abstract

Amaç: Diyabetik hastalarda duygu-durum hastalıklarının ve kognitif bozukluk insidansının genel popülasyona oranla daha yüksek olduğu bilinmektedir. Bu çalışmada, klinikte antidepresan etkinliği için reçete edilen reboksetin’in sıçanlarda diyabet ile indüklenen davranışsal ve bilişsel değişiklikler üzerine etkinliğinin araştırılması amaçlanmıştır.

Gereç ve Yöntem: Sıçanlarda deneysel diyabet modeli 50 mg/kg tek doz streptozotosin enjeksiyonu (i.v.) ile oluşturulnuştur. Reboksetin tedavisine diyabetik komplikasyonların oluşması için 4 hafta beklendikten sonra başlanmıştır. Deney hayvanlarının depresyon ve anksiyete düzeyleri sırasıyla modifiye zorlu yüzme ve yükseltilmiş artı şekilli labirent testleri ile araştırılmış; kognitif performansları ise Morris su tankı ve pasif sakınma testleri ie değerlendirilmiştir. Hayvanlarının motor aktiviteleri de aktivite kafesi ve Rota-rod testleri ile incelenmiştir.

Sonuç ve Tartışma: Deneyler sonucunda, diyabetik sıçanların depresyon ve anksiyete düzeylerinin yükseldiği ve bilişsel performanslarının zayıfladığı belirlenmiştir. İki hafta süre ile uygulanan reboksetin tedavisi (8 ve 16 mg/kg) diyabetik sıçanların yüksek depresyon ve anksiyete düzeylerini azaltırken, zayıflamış olan bilişsel performanslarını kayda değer ölçüde güçlendirmiştir. Elde edilen bulgular reboksetin’in diyabete bağlı olarak ortaya çıkan davranışsal ve bilişsel bozuklukların tedavisinde terapötik bir potansiyele sahip olabileceğine işaret etmiştir.

Keywords

Anksiyete, depresyon, Diabetes mellitus, kognisyon, reboksetin

Supporting Institution

Anadolu Üniversitesi

Project Number

Proje Numarası: 1809S307

Thanks

Bu araştırma, Anadolu Üniversitesi Bilimsel Araştırma Projeleri Komisyonu tarafından desteklenmiştir (Proje Numarası: 1809S307).

References

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BENEFICIAL EFFECTS OF REBOXETINE ON IMPAIRED BEHAVIORAL PARAMETERS OF DIABETIC RATS

Year 2023, Volume: 47 Issue: 1, 20 - 38, 20.01.2023

Nazlı Turan Yücel , Ümmühan Kandemir , Umut İrfan Üçel , Özgür Devrim Can , Ümide Demir Özkay

https://doi.org/10.33483/jfpau.1149796

Abstract

Objective: The incidence of emotional and cognitive disorders are higher in diabetic patients with respect to the general population. In this study, it was aimed to investigate the efficacy of reboxetine, a clinically prescribed drug for its antidepressant effect, on behavioral and cognitive alterations caused by diabetes in rats.

Material and Method: An experimental diabetes model in rats was induced with a single 50 mg/kg injection of streptozotocin (i.v.). Reboxetine treatment was started 4 weeks after induction of diabetes in order to observe diabetic complications. Depression and anxiety levels of experimental animals were investigated by modified forced swimming and elevated plus-maze tests, respectively; cognitive performances were evaluated by Morris water-maze and passive avoidance experiments. The motor activities of the animals were also examined with the activity cage and Rota-rod tests.

Result and Discussion: Obtained results indicated that the depression and anxiety levels of diabetic rats were increased and their cognitive performances were weakened. Reboxetine treatment (8 and 16 mg/kg) for two weeks reduced the elevated depression and anxiety levels in diabetic rats, while significantly improving their weakened cognitive performance. The findings indicated that reboxetine might possess a therapeutic potential for the cure of behavioral and cognitive impairements concomitant with diabetes.

Keywords

Anxiety, cognition, depression, Diabetes mellitus, reboxetine

Project Number

Proje Numarası: 1809S307

References

1. American Diabetes Association (2012). Diagnosis and classification of diabetes mellitus. Diabetes Care, 35(1), 64–S71. [CrossRef]
2. Wolfsdorf, J., Glaser, N., Sperling, M.A. (2006). Diabetic ketoacidosis in infants, children, and adolescents: A consensus statement from the American Diabetes Association. Diabetes Care, 29(5), 1150–1159. [CrossRef]
3. Venkatraman, R., Singhi, S.C. (2006). Hyperglycemic hyperosmolar nonketotic syndrome. Indian Journal of Pediatrics, 73(1), 55–60. [CrossRef]
4. Tripathi, B.K., Srivastava, A.K. (2006). Diabetes mellitus: Complications and therapeutics. International Medical Journal of Experimental and Clinical Research, 12(7), 130–147.
5. Forbes, J.M., Cooper, M.E. (2013). Mechanisms of diabetic complications. Physiological Reviews, 93(1), 137–188. [CrossRef]
6. Can, O.D., Öztürk, Y. (2009). Diabetes mellitus’un diğer yüzü: Psikiyatrik ve nörodejeneratif komplikasyonlar. Turkiye Klinikleri Journal of Medical Sciences, 29(4), 968-975.
7. Kovacs, M., Goldston, D., Obrosky, D.S., Bonar, L.K. (1997). Psychiatric disorders in youths with IDDM: Rates and risk factors. Diabetes Care, 20(1), 36–44. [CrossRef]
8. Pasquier, F., Boulogne, A., Leys, D., Fontaine, P. (2006). Diabetes mellitus and dementia. Diabetes & Metabolism, 32(5), 403–414. [CrossRef]
9. Yager, J.Y. (2002). Hypoglycemic injury to the immature brain. Clinics in Perinatology, 29(4), 651-674. [CrossRef]
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Details

Primary Language	Turkish
Subjects	Pharmacology and Pharmaceutical Sciences
Journal Section	Research Article
Authors	Nazlı Turan Yücel 0000-0002-0371-2703 Ümmühan Kandemir 0000-0003-3314-1961 Umut İrfan Üçel 0000-0002-5470-0139 Özgür Devrim Can 0000-0002-2260-3174 Ümide Demir Özkay 0000-0002-6773-4266
Project Number	Proje Numarası: 1809S307
Early Pub Date	November 21, 2022
Publication Date	January 20, 2023
Submission Date	July 27, 2022
Acceptance Date	October 7, 2022
Published in Issue	Year 2023 Volume: 47 Issue: 1

Cite

APA	Turan Yücel, N., Kandemir, Ü., Üçel, U. İ., Can, Ö. D., et al. (2023). REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ. Journal of Faculty of Pharmacy of Ankara University, 47(1), 20-38. https://doi.org/10.33483/jfpau.1149796
AMA	Turan Yücel N, Kandemir Ü, Üçel Uİ, Can ÖD, Demir Özkay Ü. REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ. J. Fac. Pharm. Ankara. January 2023;47(1):20-38. doi:10.33483/jfpau.1149796
Chicago	Turan Yücel, Nazlı, Ümmühan Kandemir, Umut İrfan Üçel, Özgür Devrim Can, and Ümide Demir Özkay. “REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ”. Journal of Faculty of Pharmacy of Ankara University 47, no. 1 (January 2023): 20-38. https://doi.org/10.33483/jfpau.1149796.
EndNote	Turan Yücel N, Kandemir Ü, Üçel Uİ, Can ÖD, Demir Özkay Ü (January 1, 2023) REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ. Journal of Faculty of Pharmacy of Ankara University 47 1 20–38.
IEEE	N. Turan Yücel, Ü. Kandemir, U. İ. Üçel, Ö. D. Can, and Ü. Demir Özkay, “REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ”, J. Fac. Pharm. Ankara, vol. 47, no. 1, pp. 20–38, 2023, doi: 10.33483/jfpau.1149796.
ISNAD	Turan Yücel, Nazlı et al. “REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ”. Journal of Faculty of Pharmacy of Ankara University 47/1 (January 2023), 20-38. https://doi.org/10.33483/jfpau.1149796.
JAMA	Turan Yücel N, Kandemir Ü, Üçel Uİ, Can ÖD, Demir Özkay Ü. REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ. J. Fac. Pharm. Ankara. 2023;47:20–38.
MLA	Turan Yücel, Nazlı et al. “REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ”. Journal of Faculty of Pharmacy of Ankara University, vol. 47, no. 1, 2023, pp. 20-38, doi:10.33483/jfpau.1149796.
Vancouver	Turan Yücel N, Kandemir Ü, Üçel Uİ, Can ÖD, Demir Özkay Ü. REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ. J. Fac. Pharm. Ankara. 2023;47(1):20-38.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.