KENDİLİĞİNDEN EMÜLSİFİYE OLABİLEN İLAÇ TAŞIYICI SİSTEMLER

Year 2023, Volume: 47 Issue: 2, 705 - 718, 20.05.2023

Naz Baytok Ongun Mehmet Saka

https://doi.org/10.33483/jfpau.1244378

Cited By: 1

Abstract

Amaç: Kendiliğinden emülsifiye olan ilaç taşıyıcı sistemler (SEDDS), henüz tamamen aydınlatılmamış olan muazzam bir potansiyele sahiptir. Oral lipid uygulamasında suda çözünürlüğü düşük olan ilaç bileşiklerinin formülasyonunda kullanılabilirler ve bu bileşiklerle ilişkilendirilen birçok problemin üstesinden gelebilirler. SEDDS, küçük parçacık boyutuna, geniş yüzey alanına, yüksek kapsülleme etkinliğine ve yüksek ilaç yüküne atfedilebilen bağırsak emilim bölgesindeki ilaç çözünürlüğünü optimize ederek oral emilim oranını ve derecesini artırabilir. Ayrıca, lipit bazlı formülasyonu nedeniyle SEDDS, hepatik ilk geçiş metabolizmasını atlayarak ve dolayısıyla biyoyararlanımı artırarak farmasötik lenfatik taşınmayı hızlandırabilir ve artırabilir.
Sonuç ve Tartışma: Terapötik açıdan etkili olan yeni lipofilik hidrofobik moleküllerin miktarı, yenilikçi ilaç geliştirme yaklaşımları sayesinde istikrarlı bir şekilde artmıştır. Farmasötik araştırmaların geleceği, yalnızca yeni moleküllerin keşfedilmesinden değil, aynı zamanda halihazırda bilinenlerin daha iyi kullanılmasından da geçebilir. Bu bileşiklerin oral biyoyararlanımını artırma stratejilerinden hidrofobik ve lipofilik ilaç moleküllerinin oral biyoyararlanımını artırmada SEDDS kullanımının oldukça başarılı olduğu kanıtlanmıştır.

Keywords

Emülsifiye dozaj formları, ilaç çözünürlüğü, kendiliğinden emülsifikasyon, kendiliğinden emülsifiye olabilen ilaç taşıyıcı sistemler, lipofilik ilaçlar

SELF EMULSIFYING DRUG DELIVERY SYSTEMS - AN OVERVIEW

Abstract

Objective: Self-Emulsifying Drug Delivery System (SEDDS) has tremendous potential that has yet to be completely realized. They can be used in the formulation of drug compounds that have low water solubility in oral lipid administration and overcome many problems associated with these compounds. The SEDDS can increase the rate and degree of oral absorption by optimizing drug solubility in the intestinal absorption site, attributable to its small particle size, large surface area, high encapsulation efficiency, and high drug load. Furthermore, due to its lipid-based formulation, SEDDS can accelerate and increase pharmaceutical lymphatic transport, bypassing hepatic first-pass metabolism and therefore enhancing bioavailability.
Result and Discussion: The quantity of novel therapeutically effective lipophilic molecules that are hydrophobic has steadily increased thanks to innovative drug development approaches. The future of pharmaceutical research may not only pass through the discovery of new molecules but also better exploitation of those already known. The use of SEDDS has been proven to be quite successful in enhancing the oral bioavailability of hydrophobic and lipophilic drug molecules among the strategies to increase the oral bioavailability of these compounds.

Keywords

Drug solubility, emulsifying dosage forms, lipophilic drugs, self-emulsification, self-emulsifying delivery systems

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