SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ

Songül Karakaya; Özlem Özdemir; Ümit İncekara; Hasan Türkez; Oksana Sytar; Özkan Aksakal

doi:10.33483/jfpau.1266421

Research Article

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IN VITRO ASSESSMENT OF HEMOSTATIC PERFORMANCES OF SALVIA VERTICILLATA L, ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS., AND CEPHALARIA PROCERA FISCH. & AVÉ-LALL.

Year 2023, Volume: 47 Issue: 3, 883 - 893, 20.09.2023

Songül Karakaya , Özlem Özdemir , Ümit İncekara , Hasan Türkez , Oksana Sytar , Özkan Aksakal

https://doi.org/10.33483/jfpau.1266421

Cited By: 1

Abstract

Objective: Hemostasis is an inherent function and natural process to prevent or stop bleeding. Nowadays great efforts are being made to develop novel, economical and high-performance products to control bleeding. In this study, we aimed to assess the in vitro hemostatic effects of four several plant species used in folk medicine for different purposes including Salvia verticillata, Achillea biebersteinii, Tragopogon aureus, and Cephalaria procera.
Material and Method: The extracts with different solvent nature were prepared and their hemostatic efficacy were determined using optical aggregometry.
Result and Discussion: The present results clearly revealed that the extracts of S. verticillata showed the highest efficacy on platelet aggregation in presence of adenosine-diphosphate (ADP) (80.77%), collagen (80.78%), and arachidonic acid (AA) (73.71%) when compared to other plant extracts. Again, the most effective platelet aggregation (47.27%) was determined after the application C. procera within the presence of epinephrine (EPI). Moreover, we first executed that ethyl acetate extracts led to the highest percentages of platelet aggregation in the fact of APD, collagen, AA and EPI. In a conclusion, our findings suggested that the tested medicinal plants in particular S. verticillata and C. procera could be novel and natural sources of effective hemostatic agents.

Keywords

Achillea biebersteinii, Cephalaria procera, hemostasis, Salvia verticillata, Tragopogon aureus

Supporting Institution

Atatürk University (FBA-2018-6832).

Project Number

FBA-2018-6832

References

1. Nayal, R., Abajy, M.Y., Takla, S. (2015). Investigating in vitro the hemostatic effect of some medicinal plants, Res. J of Aleppo univ, Medicine Sience Series, No.100.
2. Yılmaz, Y.K. (2013). Vascular injuries: Introduction, history, the diagnosis and treatment methods. Turkiye Klinikleri Cardiovascular Surgery-Special Topics, 5(2), 18-25.
3. Periayah, M.H., Halim, A.S., Mat, S.A.Z. (2017). Mechanism action of platelets and crucial blood coagulation pathways in hemostasis. International Journal of Hematology-Oncology and Stem Cell Research, 11(4), 319-327.
4. Ghoshal, K., Bhattacharyya, M. (2014). Overview of platelet physiology: Its hemostatic and nonhemostatic role in disease pathogenesis. The Scientific World Journal, 2014, 781857. [CrossRef]
5. Paniccia, R., Priora, R., Liotta, A.A., Abbate, R. (2015). Platelet function tests: A comparative review. Vascular Health and Risk Management, 11, 133-148. [CrossRef]
6. Ebrahimia, F., Torbati, M., Mahmoudic, J., Valizadeh, H. (2020). Medicinal plants as potential hemostatic agents. Journal of Pharmacy & Pharmaceutical Science, 23, 11-23. [CrossRef]
7. Born, G.V.R. (1962). Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature, 194, 927-929. [CrossRef]
8. Zhou, L., Schmaier, A.H. (2005). Platelet aggregation testing in platelet-rich plasma: Description of procedures with the aim to develop standards in the field. American Journal of Clinical Pathology, 123, 172-183. [CrossRef]
9. Yarali, N., Oruc, M., Bay, A., Dalgic, B., Bozkaya, I.O., Arıkoglu, T., Kara, A., Bahattin, T. (2010). A new hemostatic agent-Ankaferd blood stopper: Management of gastrointestinal bleeding in an infant and other experiences in children. Pediatric Hematology and Oncology, 27, 592-596. [CrossRef]
10. Okten, S., Kurt, M., Onal, I.K, Haznedaroglu, I.C. (2011). Use of Ankaferd blood stopper for controlling actively bleeding fundal varices. Singapore Medical Journal, 52(1), e11-2.
11. Bilgili, H., Kosar, A., Kurt, M., Onal, I.K., Goker, H., Captug, O., Shorbagi, A., Turgut, M., Kekilli, M., Kar, K.O., Kirazli, S., Aksu, S., Haznedaroglu, I.C. (2009). Hemostatic efficacy of ankaferd blood stopper in a swine bleeding model. Medical Principles and Practice. 18, 165-169. [CrossRef]
12. Tepe, B., Eminagaoglu, O., Akpulat, H.A., Aydin, E. (2007). Antioxidant potentials and rosmarinic acid levels of the methanolic extracts of Salvia verticillata (L.) subsp. verticillata and S. verticillata (L.) subsp. amasiaca (Freyn & Bornm.) Bornm. Food Chemistry, 100(3), 985-989. [CrossRef]
13. Matkowski, A., Zielińska, S., Oszmiański, J., Lamer-Zarawsk, E. (2008). Antioxidant activity of extracts from leaves and roots of Salvia miltiorrhiza Bunge, S. przewalskii Maxim., and S. verticillata L. Bioresource Technology, 99(16), 7892-7896. [CrossRef]
14. Jaffal, S.M., Manal, A.A. (2019). Antinociceptive action of Achillea biebersteinii methanolic fower extract is mediated by interaction with cholinergic receptor in mouse pain models. Infammopharmacology, 27, 961-968. [CrossRef]
15. Katanić, S.S., Srećković, N., Mišić, D., Gašić, U., Imbimbo, P., Monti, D.M., Mihailović, V. (2020). Bioactivity, biocompatibility and phytochemical assessment of lilac sage, Salvia verticillata L. (Lamiaceae)-A plant rich in rosmarinic acid. Industrial Crops and Products, 143, 111932. [CrossRef]
16. Plantlist Web site. (2019). Retrieved August 23, 2019, from http://www.theplantlist.org/tpl1.1/record/gcc-131516. Erişim tarihi: 23.08.2019.
17. Coruh, I., Gormez, A.A., Ercisli, S., Bilen, S. (2007). Total phenolics, mineral elements, antioxidant and antibacterial activities of some edible wild plants in Turkey. Asian Journal of Chemistry, 19(7), 5755-5762.
18. Karakaya, S., Polat, A., Aksakal, Ö., Sümbüllü, Y.Z., İncekara, Ü. (2019). An ethnobotanical investigation on medicinal plants in South of Erzurum (Turkey). Ethnobotany Research & Applications, 18, 13.
19. Güner, A., Aslan, S., Ekim, T., Vural, M., Babaç, M.T. (2012). Türkiye Bitkileri Listesi (Damarlı Bitkiler), İstanbul: Nezahat Gökyiğit Botanic Garden Publications, p.108, 211, 316, 580.
20. Ozgen, U., Kaya, Y., Coskun, M. (2004). Ethnobotancal studies in the villages of the district of Ilıca (province Erzurum), Turkey. Economic Botany, 58(4), 691-696.
21. Tozlu, G. (2010). Biological observations on Agapanthia osmanlis Reiche & Saulcy (Coleoptera: Cerambycidae) associated with Cephalaria procera Fisch & Lall. (Dipsacaceae) in Northeastern Turkey. Journal of Entomological Research Society, 12(1), 15.
22. Plantlist Web site. (2019). Retrieved August 23, 2019, from http://www.theplantlist.org/tpl1.1/record/kew-2709407. Erişim tarihi: 23.08.2019.
23. Singleton, V.L., Rossi, J.A. (1965). Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture, 6, 144-158.
24. Slinkard, K., Singleton, V.L. (1977). Total phenols analysis: Automation and comparison with manual methods. American Journal of Enology and Viticulture, 28, 49-55.
25. Mavi, A., Terzi, Z., Ozgen, U., Yildirim, A., Coşkun, M. (2004). Antioxidant properties of some medicinal plants: Prangos ferulacea (Apiaceae), Sedum sempervivoides (Crassulaceae), Malva neglecta (Malvaceae), Cruciata taurica (Rubiaceae), Rosa pimpinellifolia (Rosaceae), Galium verum subsp. verum (Rubiaceae), Urtica dioica (Urticaceae). Biological and Pharmaceutical Bulletin, 27, 702-705. [CrossRef]
26. Brand, W.W., Cuvelier, M.E., Berset, C. (1995) Use of a free radical method to evaluate antioxidant activity. LWT-Food Science and Technology, 28, 25-30. [CrossRef]
27. Ugur, A., Saraç, N., Çankal, D.A., Özle, M. (2016). The antioxidant and antimutagenic activities of Ankaferd blood stopper, a natural hemostatic agent used in dentistry. Turkish Journal of Medical Sciences, 46, 657-663. [CrossRef]
28. Páez, X., Hernández, L. (2003). Topical hemostatic effect of a common ornamental plant, the Geraniaceae Pelargonium zonale. The Journal of Clinical Pharmacology, 43, 291-295. [CrossRef]
29. Kose, R., Sogut, O., Erdemir, T., Koruk, I. (2012). Hemostatic efficacy of folkloric medicinal plant extract in a rat skin bleeding model. Dermatologic Surgery, 38, 760-766. [CrossRef]
30. Mekhfi, H., El Haouari, M., Legssyer, A., Bnouham, M., Aziz, M., Atmani, F., Adnane, R., Abderrahim, Z. (2004). Platelet anti-aggregant property of some Moroccan medicinal plants. Journal of Ethnopharmacology, 94, 317-322. [CrossRef]

SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ

Year 2023, Volume: 47 Issue: 3, 883 - 893, 20.09.2023

Songül Karakaya , Özlem Özdemir , Ümit İncekara , Hasan Türkez , Oksana Sytar , Özkan Aksakal

https://doi.org/10.33483/jfpau.1266421

Cited By: 1

Abstract

Amaç: Hemostaz, kanamayı önlemek veya durdurmak için doğal bir işlev ve doğal bir süreçtir. Günümüzde kanama kontrolü için yeni, ekonomik ve yüksek performanslı ürünler geliştirmek için büyük çaba sarf edilmektedir. Bu çalışmada, halk hekimliğinde farklı amaçlarla kullanılan Salvia verticillata, Achillea biebersteinii, Tragopogon aureus ve Cephalaria procera gibi dört farklı bitki türünün in vitro hemostatik etkilerini değerlendirmeyi amaçladık.
Gereç ve Yöntem: Farklı polaritelerde ekstreler hazırlandı ve hemostatik etkinlikleri optik agregometri kullanılarak belirlendi.
Sonuç ve Tartışma: Mevcut sonuçlar, diğer bitki özleri ile karşılaştırıldığında S. verticillata ekstrelerinin adenozin-difosfat (ADP) (%80.77), kollajen (%80.78) ve araşidonik asit (AA) (%73.71) varlığında trombosit agregasyonu üzerinde en yüksek etkinliği gösterdiğini açıkça ortaya koymuştur. Yine epinefrin (EPI) varlığında en etkili trombosit agregasyonu (%47.27) C. procera uygulamasından sonra belirlendi. Ayrıca, öncelikle etil asetat ekstrelerinin APD, kollajen, AA ve EPI olgusunda en yüksek trombosit agregasyonu yüzdelerini göstermiştir. Sonuç olarak, bulgularımız, özellikle S. verticillata ve C. procera'nın etkili hemostatik ajanların yeni ve doğal kaynakları olabileceğini gösterdi.

Keywords

Achillea biebersteinii, Cephalaria procera, hemostaz, Salvia verticillata, Tragopogon aureus

Project Number

FBA-2018-6832

References

1. Nayal, R., Abajy, M.Y., Takla, S. (2015). Investigating in vitro the hemostatic effect of some medicinal plants, Res. J of Aleppo univ, Medicine Sience Series, No.100.
2. Yılmaz, Y.K. (2013). Vascular injuries: Introduction, history, the diagnosis and treatment methods. Turkiye Klinikleri Cardiovascular Surgery-Special Topics, 5(2), 18-25.
3. Periayah, M.H., Halim, A.S., Mat, S.A.Z. (2017). Mechanism action of platelets and crucial blood coagulation pathways in hemostasis. International Journal of Hematology-Oncology and Stem Cell Research, 11(4), 319-327.
4. Ghoshal, K., Bhattacharyya, M. (2014). Overview of platelet physiology: Its hemostatic and nonhemostatic role in disease pathogenesis. The Scientific World Journal, 2014, 781857. [CrossRef]
5. Paniccia, R., Priora, R., Liotta, A.A., Abbate, R. (2015). Platelet function tests: A comparative review. Vascular Health and Risk Management, 11, 133-148. [CrossRef]
6. Ebrahimia, F., Torbati, M., Mahmoudic, J., Valizadeh, H. (2020). Medicinal plants as potential hemostatic agents. Journal of Pharmacy & Pharmaceutical Science, 23, 11-23. [CrossRef]
7. Born, G.V.R. (1962). Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature, 194, 927-929. [CrossRef]
8. Zhou, L., Schmaier, A.H. (2005). Platelet aggregation testing in platelet-rich plasma: Description of procedures with the aim to develop standards in the field. American Journal of Clinical Pathology, 123, 172-183. [CrossRef]
9. Yarali, N., Oruc, M., Bay, A., Dalgic, B., Bozkaya, I.O., Arıkoglu, T., Kara, A., Bahattin, T. (2010). A new hemostatic agent-Ankaferd blood stopper: Management of gastrointestinal bleeding in an infant and other experiences in children. Pediatric Hematology and Oncology, 27, 592-596. [CrossRef]
10. Okten, S., Kurt, M., Onal, I.K, Haznedaroglu, I.C. (2011). Use of Ankaferd blood stopper for controlling actively bleeding fundal varices. Singapore Medical Journal, 52(1), e11-2.
11. Bilgili, H., Kosar, A., Kurt, M., Onal, I.K., Goker, H., Captug, O., Shorbagi, A., Turgut, M., Kekilli, M., Kar, K.O., Kirazli, S., Aksu, S., Haznedaroglu, I.C. (2009). Hemostatic efficacy of ankaferd blood stopper in a swine bleeding model. Medical Principles and Practice. 18, 165-169. [CrossRef]
12. Tepe, B., Eminagaoglu, O., Akpulat, H.A., Aydin, E. (2007). Antioxidant potentials and rosmarinic acid levels of the methanolic extracts of Salvia verticillata (L.) subsp. verticillata and S. verticillata (L.) subsp. amasiaca (Freyn & Bornm.) Bornm. Food Chemistry, 100(3), 985-989. [CrossRef]
13. Matkowski, A., Zielińska, S., Oszmiański, J., Lamer-Zarawsk, E. (2008). Antioxidant activity of extracts from leaves and roots of Salvia miltiorrhiza Bunge, S. przewalskii Maxim., and S. verticillata L. Bioresource Technology, 99(16), 7892-7896. [CrossRef]
14. Jaffal, S.M., Manal, A.A. (2019). Antinociceptive action of Achillea biebersteinii methanolic fower extract is mediated by interaction with cholinergic receptor in mouse pain models. Infammopharmacology, 27, 961-968. [CrossRef]
15. Katanić, S.S., Srećković, N., Mišić, D., Gašić, U., Imbimbo, P., Monti, D.M., Mihailović, V. (2020). Bioactivity, biocompatibility and phytochemical assessment of lilac sage, Salvia verticillata L. (Lamiaceae)-A plant rich in rosmarinic acid. Industrial Crops and Products, 143, 111932. [CrossRef]
16. Plantlist Web site. (2019). Retrieved August 23, 2019, from http://www.theplantlist.org/tpl1.1/record/gcc-131516. Erişim tarihi: 23.08.2019.
17. Coruh, I., Gormez, A.A., Ercisli, S., Bilen, S. (2007). Total phenolics, mineral elements, antioxidant and antibacterial activities of some edible wild plants in Turkey. Asian Journal of Chemistry, 19(7), 5755-5762.
18. Karakaya, S., Polat, A., Aksakal, Ö., Sümbüllü, Y.Z., İncekara, Ü. (2019). An ethnobotanical investigation on medicinal plants in South of Erzurum (Turkey). Ethnobotany Research & Applications, 18, 13.
19. Güner, A., Aslan, S., Ekim, T., Vural, M., Babaç, M.T. (2012). Türkiye Bitkileri Listesi (Damarlı Bitkiler), İstanbul: Nezahat Gökyiğit Botanic Garden Publications, p.108, 211, 316, 580.
20. Ozgen, U., Kaya, Y., Coskun, M. (2004). Ethnobotancal studies in the villages of the district of Ilıca (province Erzurum), Turkey. Economic Botany, 58(4), 691-696.
21. Tozlu, G. (2010). Biological observations on Agapanthia osmanlis Reiche & Saulcy (Coleoptera: Cerambycidae) associated with Cephalaria procera Fisch & Lall. (Dipsacaceae) in Northeastern Turkey. Journal of Entomological Research Society, 12(1), 15.
22. Plantlist Web site. (2019). Retrieved August 23, 2019, from http://www.theplantlist.org/tpl1.1/record/kew-2709407. Erişim tarihi: 23.08.2019.
23. Singleton, V.L., Rossi, J.A. (1965). Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture, 6, 144-158.
24. Slinkard, K., Singleton, V.L. (1977). Total phenols analysis: Automation and comparison with manual methods. American Journal of Enology and Viticulture, 28, 49-55.
25. Mavi, A., Terzi, Z., Ozgen, U., Yildirim, A., Coşkun, M. (2004). Antioxidant properties of some medicinal plants: Prangos ferulacea (Apiaceae), Sedum sempervivoides (Crassulaceae), Malva neglecta (Malvaceae), Cruciata taurica (Rubiaceae), Rosa pimpinellifolia (Rosaceae), Galium verum subsp. verum (Rubiaceae), Urtica dioica (Urticaceae). Biological and Pharmaceutical Bulletin, 27, 702-705. [CrossRef]
26. Brand, W.W., Cuvelier, M.E., Berset, C. (1995) Use of a free radical method to evaluate antioxidant activity. LWT-Food Science and Technology, 28, 25-30. [CrossRef]
27. Ugur, A., Saraç, N., Çankal, D.A., Özle, M. (2016). The antioxidant and antimutagenic activities of Ankaferd blood stopper, a natural hemostatic agent used in dentistry. Turkish Journal of Medical Sciences, 46, 657-663. [CrossRef]
28. Páez, X., Hernández, L. (2003). Topical hemostatic effect of a common ornamental plant, the Geraniaceae Pelargonium zonale. The Journal of Clinical Pharmacology, 43, 291-295. [CrossRef]
29. Kose, R., Sogut, O., Erdemir, T., Koruk, I. (2012). Hemostatic efficacy of folkloric medicinal plant extract in a rat skin bleeding model. Dermatologic Surgery, 38, 760-766. [CrossRef]
30. Mekhfi, H., El Haouari, M., Legssyer, A., Bnouham, M., Aziz, M., Atmani, F., Adnane, R., Abderrahim, Z. (2004). Platelet anti-aggregant property of some Moroccan medicinal plants. Journal of Ethnopharmacology, 94, 317-322. [CrossRef]

There are 30 citations in total.

Details

Primary Language	Turkish
Subjects	Pharmacology and Pharmaceutical Sciences
Journal Section	Research Article
Authors	Songül Karakaya 0000-0002-3268-721X Özlem Özdemir 0000-0002-7776-1188 Ümit İncekara 0000-0002-3283-5841 Hasan Türkez 0000-0002-7046-8990 Oksana Sytar 0000-0003-4219-9292 Özkan Aksakal 0000-0003-0760-7502
Project Number	FBA-2018-6832
Early Pub Date	August 16, 2023
Publication Date	September 20, 2023
Submission Date	March 16, 2023
Acceptance Date	August 3, 2023
Published in Issue	Year 2023 Volume: 47 Issue: 3

Cite

APA	Karakaya, S., Özdemir, Ö., İncekara, Ü., Türkez, H., et al. (2023). SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ. Journal of Faculty of Pharmacy of Ankara University, 47(3), 883-893. https://doi.org/10.33483/jfpau.1266421
AMA	Karakaya S, Özdemir Ö, İncekara Ü, Türkez H, Sytar O, Aksakal Ö. SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ. J. Fac. Pharm. Ankara. September 2023;47(3):883-893. doi:10.33483/jfpau.1266421
Chicago	Karakaya, Songül, Özlem Özdemir, Ümit İncekara, Hasan Türkez, Oksana Sytar, and Özkan Aksakal. “SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ”. Journal of Faculty of Pharmacy of Ankara University 47, no. 3 (September 2023): 883-93. https://doi.org/10.33483/jfpau.1266421.
EndNote	Karakaya S, Özdemir Ö, İncekara Ü, Türkez H, Sytar O, Aksakal Ö (September 1, 2023) SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ. Journal of Faculty of Pharmacy of Ankara University 47 3 883–893.
IEEE	S. Karakaya, Ö. Özdemir, Ü. İncekara, H. Türkez, O. Sytar, and Ö. Aksakal, “SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ”, J. Fac. Pharm. Ankara, vol. 47, no. 3, pp. 883–893, 2023, doi: 10.33483/jfpau.1266421.
ISNAD	Karakaya, Songül et al. “SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ”. Journal of Faculty of Pharmacy of Ankara University 47/3 (September 2023), 883-893. https://doi.org/10.33483/jfpau.1266421.
JAMA	Karakaya S, Özdemir Ö, İncekara Ü, Türkez H, Sytar O, Aksakal Ö. SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ. J. Fac. Pharm. Ankara. 2023;47:883–893.
MLA	Karakaya, Songül et al. “SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ”. Journal of Faculty of Pharmacy of Ankara University, vol. 47, no. 3, 2023, pp. 883-9, doi:10.33483/jfpau.1266421.
Vancouver	Karakaya S, Özdemir Ö, İncekara Ü, Türkez H, Sytar O, Aksakal Ö. SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ. J. Fac. Pharm. Ankara. 2023;47(3):883-9.

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TRADITIONAL USES OF MEDICINAL PLANTS IN ERZİNCAN PROVINCE, TÜRKİYE

Ankara Universitesi Eczacilik Fakultesi Dergisi

https://doi.org/10.33483/jfpau.1329957

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.