PHARMACOPOEIA ANALYSIS OF NIOLI ESSENTIAL OIL PURCHASED FROM THE MARKET

Year 2024, Volume: 48 Issue: 1, 215 - 225, 20.01.2024

Burçin Ergene , Gizem Öztürk

https://doi.org/10.33483/jfpau.1406371

Abstract

Objective: The public's considerstion of natural resources as safe and the tendency not to use synthetic component-containing products have increased the use of essential oils recently. However, since essential oils contain a vast number of compounds, there are difficulties in standardization. For this reason, monographs are used to evaluate the quality of the essential oils and their use for therapeutic purposes. As a result of various studies, it has been shown that nioli essential oil can be used against upper respiratory tract and urinary tract infections and skin disorders and has antioxidant, anti-inflammatory, antiseptic, antifungal, antibacterial, anthelmintic, insecticidal, larvicidal and acaricidal activities. It is traditionally used against cold, influenza, cough, sinusitis, pharyngitis, rhinitis, rheumatic disorders and urinary system infections. Due to these activities and its traditional use; it is aimed to evaluate the compliance of some nioli essential oil samples available on the market with the Turkish Pharmacopoeia 2017.
Material and Method: In the content of this study; nioli essential oil samples of 5 different brands are analyzed according to the monograph given in Turkish Pharmacopoeia (2017). In the analysis; relative density, refractive index, optical rotation values were determined; organoleptic control, thin layer chromatography and gas chromatography analyzes were carried out.
Result and Discussion: As the result of the pharmacopoeia analysis conducted within the scope of the study, only one of the five nioli essential oil samples provided was found to comply with the pharmacopoeia standard. Other nioli essential oil samples did not meet the required conditions in the pharmacopoeia.

Keywords

Aromatherapy, nioli essential oil, pharmacopoeia analysis, Turkish Pharmacopoeia

Project Number

1919B012215189

PİYASADAN TEMİN EDİLEN NİOLİ UÇUCU YAĞI ÖRNEKLERİNİN FARMAKOPE ANALİZİ

Abstract

Amaç: Halk arasında doğal kaynakların güvenli olarak kabul edilmesi ve sentetik içerikli ürünlerden uzaklaşma isteği, uçucu yağ kullanımını son zamanlarda arttırmıştır. Fakat uçucu yağlar, içerisinde çok sayıda bileşik barındırdığından standardizasyon konusunda sıkıntılar yaşanmaktadır. Bu sebeple uçucu yağların kalitesini ve terapötik amaçla kullanılabilirliğini değerlendirmek için monograflardan yararlanılmaktadır. Yapılan çeşitli çalışmalar sonucunda nioli uçucu yağının; üst solunum yolu ve üriner sistem enfeksiyonlarına, cilt rahatsızlıklarına karşı kullanılabileceği ve antioksidan, antienflamatuvar, antiseptik, antifungal, antibakteriyel, antihelmintik, insektisidal, larvisidal ve akarisidal etkinliği tespit edilmiştir. Halk arasında ise soğuk algınlığı, influenza, öksürük, sinüzit, farenjit, rinit, romatizmal rahatsızlıklarda ve üriner sistem enfeksiyonlarında kullanılmaktadır. Bu etkinlikleri ve halk arasındaki kullanımından yola çıkılarak, piyasada bulunan bazı nioli uçucu yağ örneklerinin Türk Farmakopesi 2017’ye uygunluğunun değerlendirilmesi hedeflenmiştir.
Gereç ve Yöntem: Çalışma kapsamında; 5 farklı markadan temin edilen nioli uçucu yağı örneklerinin Türk Farmakopesi’nde (2017) yer alan monografa göre analiz edilmiştir. Analizde, bağıl yoğunluk, kırılım imleci, optik çevirme değerleri tespit edilmiş; organoleptik kontrol, ince tabaka kromatografisi ve gaz kromatografisi analizleri yürütülmüştür.
Sonuç ve Tartışma: Çalışma kapsamında yapılan farmakope analizi sonucunda, temin edilen beş nioli uçucu yağ numunesinden sadece bir tanesi farmakope standardına uygun olduğu bulunmuştur. Diğer nioli uçucu yağ numuneleri, farmakopede istenilen şartları karşılamamıştır.

Keywords

Aromaterapi, farmakope analizi, nioli uçucu yağı, Türk Farmakopesi

Ethical Statement

Yazarlar bu çalışma için etik kurul onayının zorunlu olmadığını beyan etmektedir.

Supporting Institution

Ankara Üniversitesi Eczacılık Fakültesi, TÜRKİYE BİLİMSEL VE TEKNOLOJİK ARAŞTIRMA KURUMU

Project Number

1919B012215189

Thanks

Yazarlar, çalışma kapsamında GC-MS analizlerine olanak sağlayan Anadolu Üniversitesi, Bitki, İlaç ve Bilimsel Araştırmalar Uygulama ve Araştırma Merkezi (AÜBİBAM)’ne teşekkürlerini sunarlar. Bu çalışma, TÜBİTAK 2209-A Üniversite Öğrencileri Araştırma Projeleri Destekleme Programı kapsamında desteklenmiştir.

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