SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY

Ahmet Hüsamettin Baran; Ahmet Berk; Ayşe Burçin Uyumlu; Özgen Arslan Solmaz; Göknur Yalım

doi:10.33483/jfpau.1443799

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SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY

Year 2024, Volume: 48 Issue: 3, 940 - 948, 10.09.2024

Ahmet Hüsamettin Baran , Ahmet Berk , Ayşe Burçin Uyumlu , Özgen Arslan Solmaz , Göknur Yalım

https://doi.org/10.33483/jfpau.1443799

Abstract

Objective: This study aimed to evaluate the effects of sildenafil (SIL) on inflammation and histopathological changes in cadmium (Cd)-induced toxicity in female rats.
Material and Method: Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF- α) levels were measured to assess the degree of inflammation. Histopathological changes in the liver, lungs and kidneys were also assessed.
Result and Discussion: SIL significantly reduced the cellular release of TNF-α and IL-6, which have been implicated in the pathogenesis of Cd-induced tissue damage. When SIL was administered alone, it showed histopathological effects similar to the control group. However, it was found that co-administration of SIL with Cd prevented portal vein dilation and central vein enlargement in the liver, prevented necrosis in kidney tissue, but did not affect the lung. Although SIL has variable protective effects on tissues, our results are in support of the idea that the use of SIL in tissue damage management can be investigated for its efficacy in modulating oxidative stress-induced proinflammatory cytokine activation in vivo and ultimately help prevent Cd-induced tissue damage. Our study has shown that SIL can reduce Cd-induced acute toxicity in rats. SIL may be use as a protective agent against toxicity of heavy metals.

Keywords

Cadmium, liver enzymes, oxidative stress, sildenafil, tissue damage

References

1. El-Habit, O.H., Abdel Moneim, A.E. (2014). Testing the genotoxicity, cytotoxicity, and oxidative stress of cadmium and nickel and their additive effect in male mice. Biological Trace Element Research, 159 (1-3), 364-372. [CrossRef]
2. Rani, A., Kumar, A., Lal, A., Pant, M. (2014). Cellular mechanisms of cadmium-induced toxicity: A review. International Journal of Environmental Health Research, 24(4), 378-399. [CrossRef]
3. Abu-El-Zahab, H.S.H., Hamza, R.Z., Montaser, M.M., El-Mahdi, M.M., Al-Harthi, W.A. (2019). Antioxidant, antiapoptotic, antigenotoxic, and hepatic ameliorative effects of L-carnitine and selenium on cadmium-induced hepatotoxicity and alterations in liver cell structure in male mice. Ecotoxicology and Environmental Safety, 173, 419-428. [CrossRef]
4. Gong, Z.G., Wang, X.Y., Wang, J.H., Fan, R.F., Wang, L. (2019). Trehalose prevents cadmium-induced hepatotoxicity by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis. Journal of Inorganic Biochemistry, 192, 62-71. [CrossRef]
5. Reyes-Becerril, M., Angulo, C., Sanchez, V., Cuesta, A., Cruz, A. (2019). Methylmercury, cadmium and arsenic(III)-induced toxicity, oxidative stress and apoptosis in Pacific red snapper leukocytes. Aquatic Toxicology, 213, 105223. [CrossRef]
6. Seif, M.M., Madboli, A.N., Marrez, D.A., Aboulthana, W.M.K. (2019). Hepato-Renal protective effects of Egyptian Purslane extract against experimental cadmium toxicity in rats with special emphasis on the functional and histopathological changes. Toxicology Reports, 6, 625-631. [CrossRef]
7. Ölmestig, J.N.E., Marlet, I.R., Hainsworth, A.H., Kruuse, C. (2017). Phosphodiesterase 5 inhibition as a therapeutic target for ischemic stroke: A systematic review of preclinical studies. Cellular Signalling, 38, 39–48. [CrossRef]
8. Fang, D., Lin, Q., Wang, C., Zheng, C., Li, Y., Huang, T., Ni, F., Wu, Z., Chen, B., Sun, L. (2020). Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats. International Immunopharmacology, 80, 106151. [CrossRef]
9. Kelly, L.E., Ohlsson, A., Shah, P.S. (2017). Sildenafil for pulmonary hypertension in neonates. Cochrane Database of Systematic Reviews, 8, 1465-1858. [CrossRef]
10. Garcia, L., Hlaing, S., Gutierrez, R., Sanchez, M., Kovanecz, I., Artaza, J., Ferrini, M. (2014). Sildenafil attenuates ınflammation and oxidative stress in pelvic ganglia neurons after bilateral cavernosal nerve damage. International Journal of Molecular Sciences, 15(10), 17204-17220. [CrossRef]
11. Jeong, K.H., Lee, T.W., Ihm, C.G., Lee, S.H., Moon, J.Y., Lim, S.J. (2009). Effects of sildenafil on oxidative and ınflammatory ınjuries of the kidney in streptozotocin-ınduced diabetic rats. American Journal of Nephrology, 29(3), 274-282. [CrossRef]
12. Zahran, M.H., Hussein, A.M., Barakat, N., Awadalla, A., Khater, S., Harraz, A., Shokeir, A.A. (2015). Sildenafil activates antioxidant and antiapoptotic genes and inhibits proinflammatory cytokine genes in a rat model of renal ischemia/reperfusion injury. International Urology and Nephrology, 47(11), 1907-1915. [CrossRef]
13. Fouad, A.A., Qureshi, H.A., Yacoubi, M.T., AL-Melhim, W.N. (2009). Protective role of carnosine in mice with cadmium-induced acute hepatotoxicity. Food and Chemical Toxicology, 47(11), 2863-2870. [CrossRef]
14. Renugadevi, J., Prabu, S.M. (2010). Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Experimental and Toxicologic Pathology, 62(2), 171-181. [CrossRef]
15. Goodarzi, Z., Karami, E., Yousefi, S., Dehdashti, A., Bandegi, A.R., Ghanbari, A. (2020). Hepatoprotective effect of atorvastatin on cadmium chloride induced hepatotoxicity in rats. Life Sciences, 254, 117770. [CrossRef]
16. Fouad, A.A., Jresat, I. (2011). Protective effect of telmisartan against cadmium-induced nephrotoxicity in mice. Life Sciences, 89(1-2), 29-35. [CrossRef]
17. Khames, A., Khalaf, M.M., Gad, A.M., Abd El-Raouf, O.M. (2017). Ameliorative effects of sildenafil and/or febuxostat on doxorubicin-induced nephrotoxicity in rats. European Journal of Pharmacology, 805, 118-124. [CrossRef]
18. Abd El Motteleb, D.M., Ibrahim, I.A.A.E.H., Elshazly, S.M. (2017). Sildenafil protects against bile duct ligation induced hepatic fibrosis in rats: Potential role for silent information regulator 1 (SIRT1). Toxicology and Applied Pharmacology, 335, 64-71. [CrossRef]
19. Kalayci, M., Kocdor, M.A., Kuloglu, T., Sahin, İ., Sarac, M., Aksoy, A., Yardim, M., Dalkilic, S., Gursu, O., Aydin, S., Akkoc, R.F., Ugras, M., Artas, G., Ozercan, İ.H., Ugur, K., Aydin, S. (2017). Comparison of the therapeutic effects of sildenafil citrate, heparin and neuropeptides in a rat model of acetic acid-induced gastric ulcer. Life Sciences, 186, 102-110. [CrossRef]
20. Fouad, A.A., Al-Mulhim, A.S., Gomaa, W. (2013). Protective effect of cannabidiol against cadmium hepatotoxicity in rats. Journal of Trace Elements in Medicine and Biology, 27(4), 355-363. [CrossRef]
21. Jin, H., Jin, F., Jin, J.X., Xu, J., Tao, T.T., Liu, J., Huang, H.J. (2013). Protective effects of Ganoderma lucidum spore on cadmium hepatotoxicity in mice. Food and Chemical Toxicology, 52, 171-175. [CrossRef]
22. Sunitha, S., Nagaraj, M., Varalakshmi, P. (2001). Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defence system in cadmium-induced hepatotoxicity in rats. Fitoterapia, 72(5), 516-523. [CrossRef]
23. Goering, P.L., Klaassen, C.D. (1984). Zinc-induced tolerance to cadmium hepatotoxicity. Toxicology and Applied Pharmacology, 74(3), 299-307. [CrossRef]
24. Klaassen, C.D., Liu, J., Diwan, B.A. (2009). Metallothionein protection of cadmium toxicity. Toxicology and Applied Pharmacology, 238(3), 215-220. [CrossRef]
25. Blazka, M.E., Shaikh, Z.A. (1991). Sex differences in hepatic and renal cadmium accumulation and metallothionein induction. Biochemical Pharmacology, 41(5), 775-780. [CrossRef]
26. Kim, Y.D., Yim, D.H., Eom, S.Y., Moon, S.I., Park, C.H., Kim, G.B., Yu, S.D., Choi, B.S., Park, J.D., Kim, H. (2014). Differences in the susceptibility to cadmium-induced renal tubular damage and osteoporosis according to sex. Environmental Toxicology and Pharmacology, 38(1), 272-278. [CrossRef]
27. Ninomiya, R., Inoue, Y., Koizumi, N., Tsukamoto, T. (1985). Effects of low protein diet and sex difference on the amounts of metallothionein in liver and kidney of cadmium-administered rats. Chemosphere, 14(11-12), 1845-1854. [CrossRef]
28. Guerra-Mora, J.R., Perales-Caldera, E., Aguilar-León, D., Nava-Sanchez, C., Díaz-Cruz, A., Díaz-Martínez, N.E., Santillán-Doherty, P., Torres-Villalobos, G., Bravo-Reyna, C.C. (2017). Effects of sildenafil and tadalafil on edema and reactive oxygen species production in an experimental model of lung ıschemia-reperfusion injury. Transplantation Proceedings, 49(6), 1461-1466. [CrossRef]
29. Lee, K.W., Jeong, J.Y., Lim, B.J., Chang, Y.K., Lee, S.J., Na, K.R., Shin, Y.T., Choi, D.E. (2009). Sildenafil attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity. Toxicology, 257(3), 137-143. [CrossRef]
30. Yildirim, A., Ersoy, Y., Ercan, F., Atukeren, P., Gumustas, K., Uslu, U., Alican, I. (2010). Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis. Pulmonary Pharmacology & Therapeutics, 23(3), 215-221. [CrossRef]
31. Uzun, H., Konukoglu, D., Nuri, M.K., Ersoy, E.Y., Özçevik, S., Yavuz, N. (2008). The effects of sildenafil citrate on ischemic colonic anastomotic healing in rats: Its relationship between nitric oxide and oxidative stress. World Journal of Surgery, 32(9), 2107-2113. [CrossRef]
32. Cadirci, E., Halici, Z., Odabasoglu, F., Albayrak, A., Karakus, E., Unal, D., Atalay, F., Ferah, I., Unal, B. (2011). Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: A biochemical and histopathological study. Clinical and Experimental Immunology, 166(3), 374-384. [CrossRef]
33. Daghfous, R., El Aidli, S., Zaiem, A., Loueslati, M.H., Belkahia, C. (2005). Sildenafil-associated hepatotoxicity. The American Journal of Gastroenterology, 100(8), 1895-1896. [CrossRef]
34. Enomoto, M., Sakaguchi, H., Ominami, M., Iwai, S., Morikawa, H., Tamori, A., Kawada, N. (2009). Sildenafil-induced severe cholestatic hepatotoxicity. The American Journal of Gastroenterology, 104(1), 254-255. [CrossRef]
35. Kayama, F., Yoshida, T., Elwell, M.R., Luster, M.I. (1995). Role of tumor necrosis factor-α in cadmium-ınduced hepatotoxicity. Toxicology and Applied Pharmacology, 131(2), 224-234. [CrossRef]
36. Chen, L., Zhou, J., Gao, W., Jiang, Y.Z. (2003). Action of NO and TNF-alpha release of rats with cadmium loading in malfunctiion of multiple system organ. Sheng Li Xue Bao: [Acta Physiologica Sinica], 55(5), 535-540.
37. Phuagkhaopong, S., Ospondpant, D., Kasemsuk, T., Sibmooh, N., Soodvilai, S., Power, C., Vivithanaporn, P. (2017). Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-κB pathways. NeuroToxicology, 60, 82-91. [CrossRef]

SİLDENAFİL CD İLE İNDÜKLENEN AKUT TOKSİSİTEDE TNF-α VE IL-6 DÜZEYLERİNİ DÜŞÜRÜR

Year 2024, Volume: 48 Issue: 3, 940 - 948, 10.09.2024

Ahmet Hüsamettin Baran , Ahmet Berk , Ayşe Burçin Uyumlu , Özgen Arslan Solmaz , Göknur Yalım

https://doi.org/10.33483/jfpau.1443799

Abstract

Amaç: Bu çalışmada, dişi sıçanlarda kadmiyum (Cd) kaynaklı toksisitede sildenafilin (SIL) inflamasyon ve histopatolojik değişiklikler üzerindeki etkilerinin değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: İnflamasyon derecesini değerlendirmek için interlökin-6 (IL-6) ve tümör nekroz faktörü-alfa (TNF- α) seviyeleri ve karaciğer, akciğer ve böbreklerdeki histopatolojik değişiklikler değerlendirilmiştir.
Sonuç ve Tartışma: SIL, Cd ile indüklenen doku hasarının patogenezinde rol oynayan TNF-α ve IL-6'nın hücresel salınımını önemli ölçüde azaltmıştır. SIL tek başına uygulandığında, kontrol grubuna benzer histopatolojik etkiler göstermiştir. Bununla birlikte, SIL'in Cd ile birlikte uygulanmasının karaciğerde portal ven genişlemesini ve merkezi ven büyümesini önlediği, böbrek dokusunda nekrozu önlediği, ancak akciğeri etkilemediği bulunmuştur. SIL'in dokular üzerinde değişken koruyucu etkileri olmasına rağmen, sonuçlarımız doku hasarı yönetiminde SIL kullanımının in vivo oksidatif stres kaynaklı proinflamatuar sitokin aktivasyonunu modüle etmedeki etkinliğinin araştırılabileceği ve nihayetinde Cd kaynaklı doku hasarını önlemeye yardımcı olabileceği fikrini desteklemektedir. Çalışmamız, SIL'in sıçanlarda Cd kaynaklı akut toksisiteyi azaltabildiğini göstermiştir. SIL, ağır metallerin toksisitesine karşı koruyucu bir ajan olarak kullanılabilir.

Keywords

Doku hasarı, kadmiyum, karaciğer enzimleri, oksidatif stres, sildenafil

References

1. El-Habit, O.H., Abdel Moneim, A.E. (2014). Testing the genotoxicity, cytotoxicity, and oxidative stress of cadmium and nickel and their additive effect in male mice. Biological Trace Element Research, 159 (1-3), 364-372. [CrossRef]
2. Rani, A., Kumar, A., Lal, A., Pant, M. (2014). Cellular mechanisms of cadmium-induced toxicity: A review. International Journal of Environmental Health Research, 24(4), 378-399. [CrossRef]
3. Abu-El-Zahab, H.S.H., Hamza, R.Z., Montaser, M.M., El-Mahdi, M.M., Al-Harthi, W.A. (2019). Antioxidant, antiapoptotic, antigenotoxic, and hepatic ameliorative effects of L-carnitine and selenium on cadmium-induced hepatotoxicity and alterations in liver cell structure in male mice. Ecotoxicology and Environmental Safety, 173, 419-428. [CrossRef]
4. Gong, Z.G., Wang, X.Y., Wang, J.H., Fan, R.F., Wang, L. (2019). Trehalose prevents cadmium-induced hepatotoxicity by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis. Journal of Inorganic Biochemistry, 192, 62-71. [CrossRef]
5. Reyes-Becerril, M., Angulo, C., Sanchez, V., Cuesta, A., Cruz, A. (2019). Methylmercury, cadmium and arsenic(III)-induced toxicity, oxidative stress and apoptosis in Pacific red snapper leukocytes. Aquatic Toxicology, 213, 105223. [CrossRef]
6. Seif, M.M., Madboli, A.N., Marrez, D.A., Aboulthana, W.M.K. (2019). Hepato-Renal protective effects of Egyptian Purslane extract against experimental cadmium toxicity in rats with special emphasis on the functional and histopathological changes. Toxicology Reports, 6, 625-631. [CrossRef]
7. Ölmestig, J.N.E., Marlet, I.R., Hainsworth, A.H., Kruuse, C. (2017). Phosphodiesterase 5 inhibition as a therapeutic target for ischemic stroke: A systematic review of preclinical studies. Cellular Signalling, 38, 39–48. [CrossRef]
8. Fang, D., Lin, Q., Wang, C., Zheng, C., Li, Y., Huang, T., Ni, F., Wu, Z., Chen, B., Sun, L. (2020). Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats. International Immunopharmacology, 80, 106151. [CrossRef]
9. Kelly, L.E., Ohlsson, A., Shah, P.S. (2017). Sildenafil for pulmonary hypertension in neonates. Cochrane Database of Systematic Reviews, 8, 1465-1858. [CrossRef]
10. Garcia, L., Hlaing, S., Gutierrez, R., Sanchez, M., Kovanecz, I., Artaza, J., Ferrini, M. (2014). Sildenafil attenuates ınflammation and oxidative stress in pelvic ganglia neurons after bilateral cavernosal nerve damage. International Journal of Molecular Sciences, 15(10), 17204-17220. [CrossRef]
11. Jeong, K.H., Lee, T.W., Ihm, C.G., Lee, S.H., Moon, J.Y., Lim, S.J. (2009). Effects of sildenafil on oxidative and ınflammatory ınjuries of the kidney in streptozotocin-ınduced diabetic rats. American Journal of Nephrology, 29(3), 274-282. [CrossRef]
12. Zahran, M.H., Hussein, A.M., Barakat, N., Awadalla, A., Khater, S., Harraz, A., Shokeir, A.A. (2015). Sildenafil activates antioxidant and antiapoptotic genes and inhibits proinflammatory cytokine genes in a rat model of renal ischemia/reperfusion injury. International Urology and Nephrology, 47(11), 1907-1915. [CrossRef]
13. Fouad, A.A., Qureshi, H.A., Yacoubi, M.T., AL-Melhim, W.N. (2009). Protective role of carnosine in mice with cadmium-induced acute hepatotoxicity. Food and Chemical Toxicology, 47(11), 2863-2870. [CrossRef]
14. Renugadevi, J., Prabu, S.M. (2010). Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Experimental and Toxicologic Pathology, 62(2), 171-181. [CrossRef]
15. Goodarzi, Z., Karami, E., Yousefi, S., Dehdashti, A., Bandegi, A.R., Ghanbari, A. (2020). Hepatoprotective effect of atorvastatin on cadmium chloride induced hepatotoxicity in rats. Life Sciences, 254, 117770. [CrossRef]
16. Fouad, A.A., Jresat, I. (2011). Protective effect of telmisartan against cadmium-induced nephrotoxicity in mice. Life Sciences, 89(1-2), 29-35. [CrossRef]
17. Khames, A., Khalaf, M.M., Gad, A.M., Abd El-Raouf, O.M. (2017). Ameliorative effects of sildenafil and/or febuxostat on doxorubicin-induced nephrotoxicity in rats. European Journal of Pharmacology, 805, 118-124. [CrossRef]
18. Abd El Motteleb, D.M., Ibrahim, I.A.A.E.H., Elshazly, S.M. (2017). Sildenafil protects against bile duct ligation induced hepatic fibrosis in rats: Potential role for silent information regulator 1 (SIRT1). Toxicology and Applied Pharmacology, 335, 64-71. [CrossRef]
19. Kalayci, M., Kocdor, M.A., Kuloglu, T., Sahin, İ., Sarac, M., Aksoy, A., Yardim, M., Dalkilic, S., Gursu, O., Aydin, S., Akkoc, R.F., Ugras, M., Artas, G., Ozercan, İ.H., Ugur, K., Aydin, S. (2017). Comparison of the therapeutic effects of sildenafil citrate, heparin and neuropeptides in a rat model of acetic acid-induced gastric ulcer. Life Sciences, 186, 102-110. [CrossRef]
20. Fouad, A.A., Al-Mulhim, A.S., Gomaa, W. (2013). Protective effect of cannabidiol against cadmium hepatotoxicity in rats. Journal of Trace Elements in Medicine and Biology, 27(4), 355-363. [CrossRef]
21. Jin, H., Jin, F., Jin, J.X., Xu, J., Tao, T.T., Liu, J., Huang, H.J. (2013). Protective effects of Ganoderma lucidum spore on cadmium hepatotoxicity in mice. Food and Chemical Toxicology, 52, 171-175. [CrossRef]
22. Sunitha, S., Nagaraj, M., Varalakshmi, P. (2001). Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defence system in cadmium-induced hepatotoxicity in rats. Fitoterapia, 72(5), 516-523. [CrossRef]
23. Goering, P.L., Klaassen, C.D. (1984). Zinc-induced tolerance to cadmium hepatotoxicity. Toxicology and Applied Pharmacology, 74(3), 299-307. [CrossRef]
24. Klaassen, C.D., Liu, J., Diwan, B.A. (2009). Metallothionein protection of cadmium toxicity. Toxicology and Applied Pharmacology, 238(3), 215-220. [CrossRef]
25. Blazka, M.E., Shaikh, Z.A. (1991). Sex differences in hepatic and renal cadmium accumulation and metallothionein induction. Biochemical Pharmacology, 41(5), 775-780. [CrossRef]
26. Kim, Y.D., Yim, D.H., Eom, S.Y., Moon, S.I., Park, C.H., Kim, G.B., Yu, S.D., Choi, B.S., Park, J.D., Kim, H. (2014). Differences in the susceptibility to cadmium-induced renal tubular damage and osteoporosis according to sex. Environmental Toxicology and Pharmacology, 38(1), 272-278. [CrossRef]
27. Ninomiya, R., Inoue, Y., Koizumi, N., Tsukamoto, T. (1985). Effects of low protein diet and sex difference on the amounts of metallothionein in liver and kidney of cadmium-administered rats. Chemosphere, 14(11-12), 1845-1854. [CrossRef]
28. Guerra-Mora, J.R., Perales-Caldera, E., Aguilar-León, D., Nava-Sanchez, C., Díaz-Cruz, A., Díaz-Martínez, N.E., Santillán-Doherty, P., Torres-Villalobos, G., Bravo-Reyna, C.C. (2017). Effects of sildenafil and tadalafil on edema and reactive oxygen species production in an experimental model of lung ıschemia-reperfusion injury. Transplantation Proceedings, 49(6), 1461-1466. [CrossRef]
29. Lee, K.W., Jeong, J.Y., Lim, B.J., Chang, Y.K., Lee, S.J., Na, K.R., Shin, Y.T., Choi, D.E. (2009). Sildenafil attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity. Toxicology, 257(3), 137-143. [CrossRef]
30. Yildirim, A., Ersoy, Y., Ercan, F., Atukeren, P., Gumustas, K., Uslu, U., Alican, I. (2010). Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis. Pulmonary Pharmacology & Therapeutics, 23(3), 215-221. [CrossRef]
31. Uzun, H., Konukoglu, D., Nuri, M.K., Ersoy, E.Y., Özçevik, S., Yavuz, N. (2008). The effects of sildenafil citrate on ischemic colonic anastomotic healing in rats: Its relationship between nitric oxide and oxidative stress. World Journal of Surgery, 32(9), 2107-2113. [CrossRef]
32. Cadirci, E., Halici, Z., Odabasoglu, F., Albayrak, A., Karakus, E., Unal, D., Atalay, F., Ferah, I., Unal, B. (2011). Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: A biochemical and histopathological study. Clinical and Experimental Immunology, 166(3), 374-384. [CrossRef]
33. Daghfous, R., El Aidli, S., Zaiem, A., Loueslati, M.H., Belkahia, C. (2005). Sildenafil-associated hepatotoxicity. The American Journal of Gastroenterology, 100(8), 1895-1896. [CrossRef]
34. Enomoto, M., Sakaguchi, H., Ominami, M., Iwai, S., Morikawa, H., Tamori, A., Kawada, N. (2009). Sildenafil-induced severe cholestatic hepatotoxicity. The American Journal of Gastroenterology, 104(1), 254-255. [CrossRef]
35. Kayama, F., Yoshida, T., Elwell, M.R., Luster, M.I. (1995). Role of tumor necrosis factor-α in cadmium-ınduced hepatotoxicity. Toxicology and Applied Pharmacology, 131(2), 224-234. [CrossRef]
36. Chen, L., Zhou, J., Gao, W., Jiang, Y.Z. (2003). Action of NO and TNF-alpha release of rats with cadmium loading in malfunctiion of multiple system organ. Sheng Li Xue Bao: [Acta Physiologica Sinica], 55(5), 535-540.
37. Phuagkhaopong, S., Ospondpant, D., Kasemsuk, T., Sibmooh, N., Soodvilai, S., Power, C., Vivithanaporn, P. (2017). Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-κB pathways. NeuroToxicology, 60, 82-91. [CrossRef]

There are 37 citations in total.

Details

Primary Language	English
Subjects	Basic Pharmacology, Medical Pharmacology
Journal Section	Research Article
Authors	Ahmet Hüsamettin Baran 0000-0003-0830-313X Ahmet Berk 0000-0002-0828-6520 Ayşe Burçin Uyumlu 0000-0001-9517-9274 Özgen Arslan Solmaz 0000-0002-8942-199X Göknur Yalım 0000-0002-1646-8674
Early Pub Date	July 28, 2024
Publication Date	September 10, 2024
Submission Date	February 27, 2024
Acceptance Date	July 8, 2024
Published in Issue	Year 2024 Volume: 48 Issue: 3

Cite

APA	Baran, A. H., Berk, A., Uyumlu, A. B., Arslan Solmaz, Ö., et al. (2024). SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY. Journal of Faculty of Pharmacy of Ankara University, 48(3), 940-948. https://doi.org/10.33483/jfpau.1443799
AMA	Baran AH, Berk A, Uyumlu AB, Arslan Solmaz Ö, Yalım G. SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY. J. Fac. Pharm. Ankara. September 2024;48(3):940-948. doi:10.33483/jfpau.1443799
Chicago	Baran, Ahmet Hüsamettin, Ahmet Berk, Ayşe Burçin Uyumlu, Özgen Arslan Solmaz, and Göknur Yalım. “SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY”. Journal of Faculty of Pharmacy of Ankara University 48, no. 3 (September 2024): 940-48. https://doi.org/10.33483/jfpau.1443799.
EndNote	Baran AH, Berk A, Uyumlu AB, Arslan Solmaz Ö, Yalım G (September 1, 2024) SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY. Journal of Faculty of Pharmacy of Ankara University 48 3 940–948.
IEEE	A. H. Baran, A. Berk, A. B. Uyumlu, Ö. Arslan Solmaz, and G. Yalım, “SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY”, J. Fac. Pharm. Ankara, vol. 48, no. 3, pp. 940–948, 2024, doi: 10.33483/jfpau.1443799.
ISNAD	Baran, Ahmet Hüsamettin et al. “SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY”. Journal of Faculty of Pharmacy of Ankara University 48/3 (September 2024), 940-948. https://doi.org/10.33483/jfpau.1443799.
JAMA	Baran AH, Berk A, Uyumlu AB, Arslan Solmaz Ö, Yalım G. SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY. J. Fac. Pharm. Ankara. 2024;48:940–948.
MLA	Baran, Ahmet Hüsamettin et al. “SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY”. Journal of Faculty of Pharmacy of Ankara University, vol. 48, no. 3, 2024, pp. 940-8, doi:10.33483/jfpau.1443799.
Vancouver	Baran AH, Berk A, Uyumlu AB, Arslan Solmaz Ö, Yalım G. SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY. J. Fac. Pharm. Ankara. 2024;48(3):940-8.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.