The Relationship Between Antropometric Measurements And Cord Blood Tenascin-C, Insulin And Glucose Levels In Diabetic Mother’s Babies

Year 2018, Volume: 15 Issue: 1, 17 - 20, 01.01.2018

Fehime Erdem Sürecek Hakan Aylanç

Abstract

Aim: To investigate whether Tenascin-C has a role in the growth of a fetus affected from a chronic inflammatory process, diabetes and to determine cord blood Tenascin-C, insulin and glucose levels in infants of diabetic mothers.Material And Methods: Infants of diabetic mothers born at >376/7 weeks of gestation group 1, n=25 and healthy controls group 2, n=35 are included in this prospective study. Anthropometric measurements of infants height, head circumference, weight, chest circumference were recorded to assess their physical development. Cord blood levels of insulin, glucose and Tenascin-C were measured at birth.Results: Totally 25 infants of diabetic mothers and 35 healthy controls were included in the study. Cord blood Tenascin-C levels were significantly higher in infants of diabetic mothers when compared with healthy neonates p

Keywords

Diabetes, insulin, inflammation, newborn, Tenascin-C

Diyabetik Anne Bebeklerinde Antropometrik Ölçümler İle Kord Kanı Tenascin-C, İnsülin Ve Glikoz Seviyelerinin İlişkisi

Abstract

Giriş: Bu çalışmada Kronik bir inflamatuar süreç olan diyabetten etkilenen fetüsün büyümesinde Tenascin-C’nin rolünün olup olmadığının araştırılması ve kord kanı Tenascin-C, insülin ve glikoz düzeylerinin karşılaştırılması amaçlanmıştır.Gereç ve Yöntemler: Bu prospektif çalışmaya gebelik haftası >376/7olan, diyabetik anne bebekleri grup 1, n=25 ile annesinde diyabet olmayan sağlıklı bebekler grup 2, n=35 dahil edildi. Bebeklerin boy, baş çevresi, tartı ve göğüs çevreleri aynı kişi tarafından ölçülüp kayıt edildi. Doğumda göbek kordonundan alınan kan örneğinden Tenascin-C, insülin, glikoz düzeyleri çalışıldı.Sonuçlar: Prenatal diyabet maruziyeti olan grup 1 ile sağlıklı yenidoğanlardan oluşan grup 2‘nin kord kanı Tenascin-C seviyeleri karşılaştırıldığında istatistiksel olarak anlamlı fark bulundu p

Keywords

Diyabet, insülin, inflamasyon, Tenascin-C, yenidoğan

References

• Hawthorne G, Robson S, Ryall EA, Sen D, Roberts SH, WardPlatt MP. Prospective population based survey of outcome of pregnancy in diabe- tic women: results of the Northern Diabetic Pregnancy Audit. BMJ. 1997 2;315(7103):279-281.
• Milley JR, Papacostas JS. Effect of insulin on metabolism of fetal sheep hind quarters. Diabetes. 1989;38(5):597-603.
• Temple R, Aldridge V, Greenwood R, Heyburn P, Sampson M, Stanley K. Association between outcome of pregnancy and glycaemic control in early pregnancy in type 1 diabetes: population based study. BMJ. 2002;325(7375):1275-1276.
• Ju H, Dixon IM. Extracellular matrix and cardiovascular diseases. Can J Cardiol. 1996;12(12):1259-1267.
• Barbour LA1, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Fried- man JE. Cellular mechanisms for insülin resistance in normal pregnancy and gestational diabetes. Diabetes Care. 2007;30 Suppl2:S112-119.
• Crossin KL, Hoffman S, Grumet M, Thiery JP, Edelman GM. Site-restri- cted expression of cytotact in during development of the chicken embr- yo.J Cell Biol. 1986;102(5):1917-1930.
• American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2013; 36: S67-74.
• Cunningham FG. Diabetes. In: Cunningham FG, Mac Donald PC, Gant NF, (eds). Williams Obstetrics. 21th ed. New York: Appleton&Lange 2001: 567-618.
• Light IJ, Keenan WJ, Sutherland JM. Maternal intravenous glucose admi- nistration as a cause of hypoglycemia in theinfant of the diabetic mother. Am J Obstet Gynecol. 1972;113(3):345-350.
• Özbörü Aşkan Ö, Bozaykut A, Sezer RG, Güran T, Bereket A. Effect of Maternal Factors and Fetomaternal Glucose Homeostasis on Birth Wei- ght and Postnatal Growth. J Clin Res Pediatr Endocrinol. 2015;7(3):168- 174.
• Luhete PK, Mukuku O, Kiopin PM, Tambwe AM, Kayamba PK. Fetal mac- rosomia in Lubumbashi: risk factors and maternal and perinatal progno- sis. Pan Afr Med J. 2016;23:166.
• HAPO STUDY COOPERATİVE RESEARCH GROUP et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358(19):1991- 2002.
• de Medeiros TS, Bernardi JR, de Brito ML, Bosa VL, Goldani MZ, da Silva CH. Caffeine Intake During Pregnancy in Different Intrauterine Environ- mentsandits Association with Infant Anthropometric Measurements at 3 and 6 Months of Age. Matern Child Health J. 2017;21(6):1297-1307.
• Lemons JA, Vargas P, Delaney JJ. Infant of thediabeticmother: review of 225 cases. ObstetGynecol. 1981;57(2):187-192.