Abstract
Amaç: Polikistik over sendromlu (PKOS) kadınların yaklaşık %70'inde insülin direnci ve buna bağlı metabolik bozukluklar vardır, ancak insülin direncine yol açan altta yatan mekanizma bilinmemektedir. Betatrofin, karaciğerde ve yağ dokusunda eksprese edilen ve insülin direnci ve β-hücre proliferasyonu ile ilişkili olduğu bulunan bir proteindir. Bu çalışmanın amacı, PKOS olgularında dolaşımdaki betatrofin düzeyini değerlendirmek ve obezite ve insülin direnci ile ilişkisini araştırmaktır.
Yöntemler: Bu prospektif kesitsel çalışmada, ELİSA test kitleri kullanılarak normo-ağırlıklı 35 tane PCOS vakasında ve 38 tane fazla kilolu/obez PCOS vakasında (BMI≥25) dolaşan betatrofin seviyeleri ölçüldü. Betatrofin seviyeleri, antropometrik ölçümler, açlık kan şekeri, glikoz yüklemesinden 2 saat sonra kan şekeri ve insülin direncinin homeostaz modeli değerlendirmesi (HOMA-IR) değerleri karşılaştırıldı.
Bulgular: Normal ağırlıklı PKOS grubunun dolaşımdaki betatrofin düzeyleri aşırı kilolu/obez PKOS grubuna göre anlamlı derecede yüksek bulundu (p=0,023). Betatrofin ve HOMA-IR seviyeleri arasında anlamlı bir ilişki yoktu.
Sonuç: Betatrofin, aşırı kilolu/obez grupta normo-ağırlıklı PKOS grubuna göre anlamlı derecede düşük bulundu. Betatrofinin PKOS ve insülin direncindeki rolü yeterince aydınlatılamadığından PKOS hastalarında insülin direncinin iyi bir öngörücüsü olmadığı söylenebilir.
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References
- 1. Kahraman S, Altinova AE, Yalcin MM, Gulbahar O, Arslan B, Akturk M, Cakir N ,Toruner FB. Association of serum betat- rophin with fibroblast growth factor-21 in women with polycys- tic ovary syndrome. Journal of endocrinological investigation. 2018; 41(9), 1069-1074. 2. Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz, R. Poly- cystic ovary syndrome: etiology, pathogenesis and diagnosis. Nature reviews endocrinology. 2011; 7(4), 219-231. 3. Li L, Zhang F, Cui J, Shi Y, Xiang J, Wang X et al. Associa- tion of betatrophin with metabolic characteristics in overweight/ obese and lean women with PCOS. Gynecological Endocrino- logy. 2017; 33(3), 238-243.
THE RELATIONSHIP BETWEEN CIRCULATING BETATROPHIN LEVELS AND INSULIN RESISTANCE IN NORMO-WEIGHT AND OVERWEIGHT/OBESE PCOS
Abstract
Objective: About 70% of women with polycystic ovary syndrome (PCOS) have insulin resistance and related metabolic disorders but the underlying mechanism leading to insulin resistance remain unknown. Betatrophin is a protein expressed in the liver and adipose tissue that has been found to be related to insulin resistance and β-cell proliferation. The aim of this study is evaluate the circulating betatrophin level in PCOS cases and to investigate its relationship with obesity and insulin resistance.
Methods: In this prospective cross-sectional study circulating betatrophin levels were measured in 35 PCOS cases with normo-weight and 38 overweight/ obese PCOS cases (BMI≥25) using spesific enzyme-linked immunosorbent assay kits. Betatrophin levels, antropometric measurements, fasting blood glucose, 2 -hour post-glucose load blood glucose and homeostasis model assessment of insulin resistance (HOMA-IR) values were compared.
Results: Circulating betatrophin levels of the normo-weight PCOS group were found to be significantly higher than the overweight/obese PCOS group (p=0.023). There were no significant association between betatrophin and HOMA-IR levels.
Conclusion:Betatrophin was found to be significantly lower in the overweight/obese group than in the normo-weight PCOS group. Since the role of betatrophin in PCOS and insulin resistance has not been sufficiently clarified, it can be said that it is not a good predictor of insulin resistance in PCOS patients.
Project Number
yok
References
- 1. Kahraman S, Altinova AE, Yalcin MM, Gulbahar O, Arslan B, Akturk M, Cakir N ,Toruner FB. Association of serum betat- rophin with fibroblast growth factor-21 in women with polycys- tic ovary syndrome. Journal of endocrinological investigation. 2018; 41(9), 1069-1074. 2. Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz, R. Poly- cystic ovary syndrome: etiology, pathogenesis and diagnosis. Nature reviews endocrinology. 2011; 7(4), 219-231. 3. Li L, Zhang F, Cui J, Shi Y, Xiang J, Wang X et al. Associa- tion of betatrophin with metabolic characteristics in overweight/ obese and lean women with PCOS. Gynecological Endocrino- logy. 2017; 33(3), 238-243.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Obstetrics and Gynaecology |
| Journal Section | Research Articles |
| Authors | |
| Project Number | yok |
| Publication Date | April 1, 2024 |
| Submission Date | June 16, 2023 |
| Acceptance Date | February 7, 2024 |
| Published in Issue | Year 2024 Volume: 21 Issue: 1 |