Do Mean Platelet Volume and Red Cell Distribution Width Predict Mortality in Patients with Acute Respiratory Distress Syndrome?

Year 2019, Volume: 4 Issue: 4, 97 - 106, 31.12.2019

Gülseren Yilmaz , Ziya Salihoglu

Abstract

Background:
To investigate the role of mean platelet
volume (MPV), red cell distribution width (RDW) and other parameters of
complete blood count on predicting mortality in patients withacute respiratory
distress syndrome (ARDS).

Methods:
Forty-six patients admitted to the
intensive care unit of our institute -a tertiary center- with ARDS between
April 2016 and January 2019 were retrospectively recruited in the study. Demographic
and clinical data including age, gender, accompanying chronic diseases, the
Acute Physiology and Chronic Health Evaluation (APACHE) scores and laboratory
test results were retrospectively collected from medical records and electronic
databases. The study population was divided into two groups according to the
development of mortality as survivors or non-survivors.

Results:
Twenty-five subjects died during the
in-hospital course (non-survivors) and 21 survived (survivors). APACHE II
scores, MPV, RDW
andneutrophil–lymphocyte ratio (NLR) were significantly higher in the
non-survivors group compared to that of the survivors. Multiple logistic
regression analysis revealed that MPV and RDW were independent predictors of
mortality in patients with ARDS.  ROC
curve analysis indicated a cut-off value of 8.11 fl for MPV (sensitivity 88%, specificity86%)
and 14.45 % for RDW (sensitivity 84%, specificity86 %) to predict mortality in
patients with ARDS.

Conclusions:
MPV, as an emerging indicator of
preexisting inflammation, and RDW indicating inflammation, independently
predict mortality in patients with ARDS. Implementation of MPV and RDW might be
useful in identifying patients who will require advanced support during admission
for ARDS.  

Keywords

Acute respiratory distress syndrome, mean platelet volume, red blood cell distribution width

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