Personalized Antigen Receptor with Cell Therapy (CAR-T)

Year 2019, Volume: 9 Issue: 4, 2235 - 2245, 01.12.2019

Özlem Gök , Abdullah Aslan

https://doi.org/10.21597/jist.591578

Cited By: 1

Abstract

Given the use of the body's own immune system, immunotherapy; promises a more effective and durable treatment than traditional treatments to treat cancer. A type of immunotherapy chimeric antigen receptor-T (CAR-T) cell therapy is a promising new T cell immunotherapy in cancer treatment. CAR-T a fusion protein comprising an antigen recognition fragment and T cell signaling sites. CAR-T cell, predominantly; acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), lymphoma (lymph cancer), multiple myeloma (bone marrow cancer) have been used in the treatment of hematological cancers. CAR-T cell; melanoma (skin cancer), breast cancer and sarcoma (tumor in the connective tissue), such as the treatment of tumors promises great promise. Studies are underway to improve chimeric antigen receptor technology to increase safety and efficacy, reduce production costs and make it more applicable than hematological cancers, and the number of clinical trials continues to grow exponentially.

Keywords

immünoterapi, kimerik antijen reseptörü, T lenfosit

Kişiye Özgü Geliştirilen Antijen Reseptörü ile Hücre Tedavisi (CAR-T)

Abstract

Vücudun kendi bağışıklık sisteminin kullanımı göz önüne alındığında, immünoterapi olarak adlandırılan tedavi; kanseri tedavi etmek için geleneksel tedavilerden daha etkili ve dayanıklı bir tedavi vaat etmektedir. Bir tür immünoterapi olan kimerik antijen reseptörü-T (CAR-T) hücre tedavisi, kanser tedavisinde umut verici yeni bir T hücresi immünoterapisidir. CAR-T; bir antijen tanıma parçası ve T hücresi sinyalleşme alanlarından oluşan bir füzyon proteinidir. CAR-T hücresi, ağırlıklı olarak; akut lenfoblastik lösemi (ALL), kronik lenfositik lösemi (KLL), lenfoma (Lenf kanseri), multipl miyeloma (kemik iliği kanseri) dahil olmak üzere hematolojik kanserlerin tedavisinde kullanılmıştır. CAR-T hücresi; melanom (cilt kanseri), meme kanseri ve sarkom (bağ dokusunda oluşan tümör) gibi tümörlerin tedavisinde ise büyük umut vaat etmektedir. Güvenlik ve etkinliği artırmak, üretim maliyetlerini azaltmak ve hematolojik kanserlerin ötesinde uygulanabilir kılmak için kimerik antijen reseptörü teknolojisinin iyileştirilmesine yönelik çalışmalar yürütülmekte ve klinik çalışmaların sayısı katlanarak artmaya devam etmektedir.

Keywords

İmmünoterapi, kimerik antijen reseptörü, T lenfosit

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