Farklı Moleküler Ağırlıklı Kitosan Katkılı Hidroksiapatit/Kitosan Biyokompozit Kaplamaların Araştırılması

Year 2023, Volume: 13 Issue: 3, 1703 - 1712, 01.09.2023

Tuncay Dilsizoğlu , İsmail Hakki Karahan , Ali Tozar

https://doi.org/10.21597/jist.1190305

Abstract

Kemiğin yapısına en yakın olan kalsiyum fosfat; (Ca10(PO4)6(OH)2) oranının olduğu hidroksiapatittir (HA). Ancak polimer katkısıyla hidroksiapatitin (HA) mukavemet ve sertlik gibi mekanik özelliklerinin arttırıldığı bilinmektedir. Düşük toksiklik ve yüksek biyouyumluluk özelliklerinden dolayı kitosan (CTS) polimer olarak kullanıldı. HA/CTS kaplamaları yapılırken orta moleküler ağırlıklı (MMW) ve yüksek moleküler ağırlıklı (HMW) olmak üzere iki farklı moleküler ağırlıklı kitosan kullanıldı. Orta ve yüksek moleküler ağırlıklı kitosan katkılanarak HA/CTS biyokompozit kaplamalarının etkisi incelendi. Kaplamalar ultasonik destekli elektroforetik yöntemle üretildi. Kristalografik, morfolojik yapıları FT-IR, XRD ve SEM ile incelendi. Yüksek moleküler ağırlıklı kitosan değeri arttıkça numunenin yapısının daha homojen olduğu belirlendi.

Keywords

Hidroksiapatit, Kitosan, Biyokompozit, Ultrasonik, Elektroforetik depolama

Supporting Institution

Hatay Mustafa Kemal Üniversitesi

Project Number

18.D.015

Thanks

Bu çalışmayı 18.D.015 proje numarası ile desteklediği için Hatay Mustafa Kemal Üniversitesi BAP Birimine teşekkür ederiz.

Investigation of Different Molecular Weights Chitosan Added Hydroxyapatite/Chitosan Biocomposite Coatings

Abstract

Which is the nearest of the bone structure of calcium phosphate rate (HAp, Ca10(PO4)6(OH)2) is hydroxyapatite. However, it is known that the mechanical properties of hydroxyapatite (HAp) such as strength and hardness are increased with polymer additives. Chitosan (CTS) was used as the polymer due to its low toxicity and high biocompatibility properties. Two types of chitosan were used while making HAp/CTS coatings. Medium molecular weight (MMW) and high molecular weight (HMW). The effect of HAp/CTS biocomposite coatings by doping with medium and high molecular weight chitosan was investigated. The coatings were produced by the ultrasonic assisted electrophoretic method. Their crystallographic and morphological structures were examined by FT-IR, XRD and SEM. The structure of the sample become more homogeneous as the high molecular weight chitosan value increased.

Keywords

Hydroxypatite, Chitosan, Biocomposite, Ultrasonic, Electrophoretic deposition

Project Number

18.D.015

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