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PERIODONTAL TREATMENT OUTCOMES IN POST MENOPAUSAL WOMEN RECEIVING HORMONE REPLACEMENT THERAPY

Year 2015, Volume: 49 Issue: 3, 39 - 44, 05.08.2015
https://doi.org/10.17096/jiufd.61637

Abstract

Purpose: To evaluate the effect of hormone replacement
therapy(HRT) on periodontal treatment outcomes in
a group of postmenopausal women with periodontitis.
Materials and Methods: 23 post-menopausal
chronic periodontitis patients were included in this
study. The test group(n=11) consisted of women
who started HRT with this study and received
conjugated estrogen and medroxyprogesteron. The
control group(n=12) was women not taking any HRT
or supplement therapy. Study groups received the
same periodontal treatment. All subjects examiend
by recording the following: plaque index (PI), sulcus
bleeding index (SBI), periodontal pocket depth (PD)
and relative attachment level (RAL) from 6 sites in
each tooth. Measurements were recorded at the
baseline, 1 month, 3 months, and 6 months following
periodontal treatment. Serum estrogene level and
bone mineral density was recorded at baseline
and 6 months following periodontal treatment.
Results: The GI change was greater in the
control group. There wasn’t significant difference
by means of PD, the attachment gain was
significantly greater in the HRT receiving group.
Conclusion: HRT seems to have a positive
effect on periodontal treatment outcomes.

References

  • Paulander J, Axelsson P, Lindhe J. Association between level of education and oral health status in 35-, 50-, 65- and 75-year-olds. J Clin Periodontol 2003;30(8):697-704.
  • Mascarenhas P, Gapski R, Al-Shammari K, Wang HL. Influence of sex hormones on the periodontium. J Clin Periodontol 2003;30(8):671-681.
  • Reddy MS. Reaching a better understanding of non-oral disease and the implication of periodontal infections. Periodontol 2000 2007;44:(9-14).
  • Krejci CB, Bissada NF. Women's health issues and their relationship to periodontitis. J Am Dent Assoc 2002;133(3):323-329.
  • Geurs NC. Osteoporosis and periodontal disease. Periodontol 2000 2007;44(29-43).
  • Lerner UH. Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis. J Dent Res 2006;85(7):596-607.
  • Wactawski-Wende J. Periodontal diseases and osteoporosis: Association and mechanisms. Ann Periodontol 2001;6(1):197-208.
  • Friedlander AH. The physiology, medical management and oral implications of menopause. J Am Dent Assoc 2002;133(1):73-81.
  • Caufriez A. Hormonal replacement therapy (hrt) in postmenopause: A reappraisal. Ann Endocrinol (Paris) 2007;68(4):241-250.
  • Harman SM. Estrogen replacement in menopausal women: Recent and current prospective studies, the whi and the keeps. Gend Med 2006;3(4):254-269.
  • Gambacciani M, Ciaponi M, Genazzani AR. The hrt misuse and osteoporosis epidemic: A possible future scenario. Climacteric 2007;10(4):273-275.
  • Payne JB, Zachs NR, Reinhardt RA, Nummikoski PV, Patil K. The association between estrogen status and alveolar bone density changes in postmenopausal women with a history of periodontitis. J Periodontol 1997;68(1):24-31.
  • Speroff L. FM. Clinical gynecologic endocrinology and infertility: Lippincott Williams & Wilkins; 2005.
  • Cauley JA, Robbins J, Chen Z, Cummings SR, Jackson RD, LaCroix AZ, LeBoff M, Lewis CE, McGowan J, Neuner J, Pettinger M, Stefanick ML, Wactawski-Wende J, Watts NB. Effects of estrogen plus progestin on risk of fracture and bone mineral density: The women's health initiative randomized trial. JAMA 2003;290(13):1729-1738.
  • U.S. Preventive Services Task Force. Hormone therapy for the prevention of chronic conditions in postmenopausal women: Recommendations from the U.S. Preventive services task force. Ann Intern Med 2005;142(10):855-860.
  • Reinhardt RA, Payne JB, Maze CA, Patil KD, Gallagher SJ, Mattson JS. Influence of estrogen and osteopenia/osteoporosis on clinical periodontitis in postmenopausal women. J Periodontol 1999;70(8):823-828.
  • Ronderos M, Jacobs DR, Himes JH, Pihlstrom BL. Associations of periodontal disease with femoral bone mineral density and estrogen replacement therapy: Cross-sectional evaluation of US adults from nhanes iii. J Clin Periodontol 2000;27(10):778-786.
  • Pizzo G, Guiglia R, Licata ME, Pizzo I, Davis JM, Giuliana G. Effect of hormone replacement therapy (hrt) on periodontak status of postmenopausal women. Med Sci Monit 2011;17(4):23-27.
  • Lundstrom A, Jendle J, Stenstrom B, Toss G, Ravald N. Periodontal conditions in 70-year-old women with osteoporosis. Swed Dent J 2001;25(3):89-96.
  • Amar S, Chung KM. Influence of hormonal variation on the periodontium in women. Periodontol 2000 1994;6:(79-87).
  • Daniell HW. Periodontitis in estrogen-deficient women. Arch Intern Med 2002;162(22):2634-2635.
  • Genco RJ, Grossi SG. Is estrogen deficiency a risk factor for periodontal disease? Compend Contin Educ Dent Suppl 1998;22, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1208975822):S23-29.
  • Geurs NC, Lewis CE, Jeffcoat MK. Osteoporosis and periodontal disease progression. Periodontol 2000 2003;32:(105-110).
  • Grossi SG. Effect of estrogen supplementation on periodontal disease. Compend Contin Educ Dent Suppl 1998;22, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1208975922):S30-36.
  • Hildebolt CF. Osteoporosis and oral bone loss.Dentomaxillofac Radiol 1997;26(1):3-15.
  • Inagaki K, Kurosu Y, Kamiya T, Kondo F, Yoshinari N, Noguchi T, Krall EA, Garcia RI. Low metacarpal bone density, tooth loss, and periodontal disease in japanese women. J Dent Res 2001;80(9):1818-1822.
  • Inagaki K, Noguchi T. [osteoporosis: A risk factor in periodontal disease]. Clin Calcium 2002;12(7):978-986.
  • Krook L, Whalen JP, Lesser GV, Lutwak L. Human periodontal disease and osteoporosis. Cornell Vet 1972;62(3):371-391.
  • Lai YL. Osteoporosis and periodontal disease. J Chin Med Assoc 2004;67(8):387-388.
  • Loza JC, Carpio LC, Dziak R. Osteoporosis and its relationship to oral bone loss. Curr Opin Periodontol 1996;3:(27-33).
  • Lundstrom A. JJ, Stenstrom B., Toss G., Ravald N. The physiology, medical management and oral implications of menopause. J Am Dent Assoc. 2002;133:(73-81).
  • Mohammad AR, Hooper DA, Vermilyea SG, Mariotti A, Preshaw PM. An investigation of the relationship between systemic bone density and clinical periodontal status in post-menopausal asian-american women. Int Dent J 2003;53(3):121-125.
  • Payne JB, Reinhardt RA, Masada MP, DuBois LM, Allison AC. Gingival crevicular fluid il-8: Correlation with local il-1 beta levels and patient estrogen status. J Periodontal Res 1993;(28):451-453.
  • Pilgram TK, Hildebolt CF, Yokoyama-Crothers N, Dotson M, Cohen SC, Hauser JF, Kardaris E. Relationships between radiographic alveolar bone height and probing attachment level: Data from healthy post-menopausal women. J Clin Periodontol 2000;27(5):341-346.
  • Shen EC, Gau CH, Hsieh YD, Chang CY, Fu E. Periodontal status in post-menopausal osteoporosis: A preliminary clinical study in taiwanese women. J Chin Med Assoc 2004;67(8):389-393.
  • Tezal M, Wactawski-Wende J, Grossi SG, Ho AW, Dunford R, Genco RJ. The relationship between bone mineral density and periodontitis in postmenopausal women. J Periodontol 2000;71(9):1492-1498.
  • Daltaban O, Saygun I, Bal B, Balos K, Serdar M. Gingival crevicular fluid alkaline phosphatase levels in postmenopausal women: Effects of phase i periodontal treatment. J Periodontol 2006;77(1):67-72.
  • Norderyd OM, Grossi SG, Machtei EE, Zambon JJ, Hausmann E, Dunford RG, Genco RJ. Periodontal status of women taking postmenopausal estrogen supplementation. J Periodontol 1993;64(10):957-962.
  • Lopez-Marcos JF, Garcia-Valle S, Garcia-Iglesias AA. Periodontal aspects in menopausal women undergoing hormone replacement therapy. Med Oral Patol Oral Cir Bucal 2005;10(2):132-141.
  • Silness J, Loe H. Periodontal disease in pregnancy. Ii. Correlation between oral hygiene and periodontal condtion. Acta Odontol Scand 1964;22:(121-135).
  • Muhlemann HR, Son S. Gingival sulcus bleeding--a leading symptom in initial gingivitis. Helv Odontol Acta 1971;15(2):107-113.
  • Pilgram TK, Hildebolt CF, Yokoyama-Crothers N, Dotson M, Cohen SC, Hauser JF, Kardaris E. Relationships between longitudinal changes in radiographic alveolar bone height and probing depth measurements: Data from postmenopausal women. J Periodontol 1999;70(8):829-833.
  • Mohammad AR, Brunsvold M, Bauer R. The strength of association between systemic postmenopausal osteoporosis and periodontal disease. Int J Prosthodont 1996;9(5):479-483.
  • Mealey BL, Moritz AJ. Hormonal influences: Effects of diabetes mellitus and endogenous female sex steroid hormones on the periodontium. Periodontol 2000 2003;32:(59-81).
  • Garcia RI, Henshaw MM, Krall EA. Relationship between periodontal disease and systemic health. Periodontol 2000 2001;25(21-36).
  • Straub RH. The complex role of estrogens in inflammation. Endocr Rev 2007;28(5):521-574.

Hormon Replasman Tedavisi Alan Postmenopozal Dönemdeki Kadınlarda Periodontal Tedavinin Etkileri

Year 2015, Volume: 49 Issue: 3, 39 - 44, 05.08.2015
https://doi.org/10.17096/jiufd.61637

Abstract

Amaç: Bu çalışmanın amacı periodontitisli postmenopozal kadınlarda postmenopozal hormon tedavisinin (PHT), periodontal başlangıç tedavisi sonuçları üzerindeki etkilerini incelemektir.Gereç ve Yöntem: 23 kronik periodontitisli daha önce hormon tedavisi görmemiş olan postmenopozal kadın çalışmaya dâhil edilmiştir. Deney grubuna (n=11) konjuge östrojen ve medroxyprogesteron kullandırılmış, kontrol grubuna(n=12) herhangi bir hormon tedavisi verilmemiştir. Çalışmadaki tüm bireyler bireylere aynı periodontal başlangıç tedavisi uygulanmıştır. Plak indeksi(PI), dişeti oluğu kanama indeksi (DOKİ), sondalanabilir cep derinliği (SD), rölatif ataşman düzeyi (RAD) ölçümleri başlangıçta, 1., 3., ve 6. aylarda, serum östrojen düzeyi, sistemik kemik yoğunluğu ölçümleri başlangıçta ve 6. ayda gerçekleştirilmiştir. Bulgular: DOKİ, kontrol grubunda daha fazla değişim göstermiştir. SD açısından gruplar arasında fark yoktur. PHT kullanmakta olan kadınlarda klinik atasman kazanci daha fazla bulunmuştur. Sonuç: PHT kullanımının periodontal tedavi sonuclarina olumlu katki sağladığı söylenebilir

References

  • Paulander J, Axelsson P, Lindhe J. Association between level of education and oral health status in 35-, 50-, 65- and 75-year-olds. J Clin Periodontol 2003;30(8):697-704.
  • Mascarenhas P, Gapski R, Al-Shammari K, Wang HL. Influence of sex hormones on the periodontium. J Clin Periodontol 2003;30(8):671-681.
  • Reddy MS. Reaching a better understanding of non-oral disease and the implication of periodontal infections. Periodontol 2000 2007;44:(9-14).
  • Krejci CB, Bissada NF. Women's health issues and their relationship to periodontitis. J Am Dent Assoc 2002;133(3):323-329.
  • Geurs NC. Osteoporosis and periodontal disease. Periodontol 2000 2007;44(29-43).
  • Lerner UH. Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis. J Dent Res 2006;85(7):596-607.
  • Wactawski-Wende J. Periodontal diseases and osteoporosis: Association and mechanisms. Ann Periodontol 2001;6(1):197-208.
  • Friedlander AH. The physiology, medical management and oral implications of menopause. J Am Dent Assoc 2002;133(1):73-81.
  • Caufriez A. Hormonal replacement therapy (hrt) in postmenopause: A reappraisal. Ann Endocrinol (Paris) 2007;68(4):241-250.
  • Harman SM. Estrogen replacement in menopausal women: Recent and current prospective studies, the whi and the keeps. Gend Med 2006;3(4):254-269.
  • Gambacciani M, Ciaponi M, Genazzani AR. The hrt misuse and osteoporosis epidemic: A possible future scenario. Climacteric 2007;10(4):273-275.
  • Payne JB, Zachs NR, Reinhardt RA, Nummikoski PV, Patil K. The association between estrogen status and alveolar bone density changes in postmenopausal women with a history of periodontitis. J Periodontol 1997;68(1):24-31.
  • Speroff L. FM. Clinical gynecologic endocrinology and infertility: Lippincott Williams & Wilkins; 2005.
  • Cauley JA, Robbins J, Chen Z, Cummings SR, Jackson RD, LaCroix AZ, LeBoff M, Lewis CE, McGowan J, Neuner J, Pettinger M, Stefanick ML, Wactawski-Wende J, Watts NB. Effects of estrogen plus progestin on risk of fracture and bone mineral density: The women's health initiative randomized trial. JAMA 2003;290(13):1729-1738.
  • U.S. Preventive Services Task Force. Hormone therapy for the prevention of chronic conditions in postmenopausal women: Recommendations from the U.S. Preventive services task force. Ann Intern Med 2005;142(10):855-860.
  • Reinhardt RA, Payne JB, Maze CA, Patil KD, Gallagher SJ, Mattson JS. Influence of estrogen and osteopenia/osteoporosis on clinical periodontitis in postmenopausal women. J Periodontol 1999;70(8):823-828.
  • Ronderos M, Jacobs DR, Himes JH, Pihlstrom BL. Associations of periodontal disease with femoral bone mineral density and estrogen replacement therapy: Cross-sectional evaluation of US adults from nhanes iii. J Clin Periodontol 2000;27(10):778-786.
  • Pizzo G, Guiglia R, Licata ME, Pizzo I, Davis JM, Giuliana G. Effect of hormone replacement therapy (hrt) on periodontak status of postmenopausal women. Med Sci Monit 2011;17(4):23-27.
  • Lundstrom A, Jendle J, Stenstrom B, Toss G, Ravald N. Periodontal conditions in 70-year-old women with osteoporosis. Swed Dent J 2001;25(3):89-96.
  • Amar S, Chung KM. Influence of hormonal variation on the periodontium in women. Periodontol 2000 1994;6:(79-87).
  • Daniell HW. Periodontitis in estrogen-deficient women. Arch Intern Med 2002;162(22):2634-2635.
  • Genco RJ, Grossi SG. Is estrogen deficiency a risk factor for periodontal disease? Compend Contin Educ Dent Suppl 1998;22, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1208975822):S23-29.
  • Geurs NC, Lewis CE, Jeffcoat MK. Osteoporosis and periodontal disease progression. Periodontol 2000 2003;32:(105-110).
  • Grossi SG. Effect of estrogen supplementation on periodontal disease. Compend Contin Educ Dent Suppl 1998;22, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1208975922):S30-36.
  • Hildebolt CF. Osteoporosis and oral bone loss.Dentomaxillofac Radiol 1997;26(1):3-15.
  • Inagaki K, Kurosu Y, Kamiya T, Kondo F, Yoshinari N, Noguchi T, Krall EA, Garcia RI. Low metacarpal bone density, tooth loss, and periodontal disease in japanese women. J Dent Res 2001;80(9):1818-1822.
  • Inagaki K, Noguchi T. [osteoporosis: A risk factor in periodontal disease]. Clin Calcium 2002;12(7):978-986.
  • Krook L, Whalen JP, Lesser GV, Lutwak L. Human periodontal disease and osteoporosis. Cornell Vet 1972;62(3):371-391.
  • Lai YL. Osteoporosis and periodontal disease. J Chin Med Assoc 2004;67(8):387-388.
  • Loza JC, Carpio LC, Dziak R. Osteoporosis and its relationship to oral bone loss. Curr Opin Periodontol 1996;3:(27-33).
  • Lundstrom A. JJ, Stenstrom B., Toss G., Ravald N. The physiology, medical management and oral implications of menopause. J Am Dent Assoc. 2002;133:(73-81).
  • Mohammad AR, Hooper DA, Vermilyea SG, Mariotti A, Preshaw PM. An investigation of the relationship between systemic bone density and clinical periodontal status in post-menopausal asian-american women. Int Dent J 2003;53(3):121-125.
  • Payne JB, Reinhardt RA, Masada MP, DuBois LM, Allison AC. Gingival crevicular fluid il-8: Correlation with local il-1 beta levels and patient estrogen status. J Periodontal Res 1993;(28):451-453.
  • Pilgram TK, Hildebolt CF, Yokoyama-Crothers N, Dotson M, Cohen SC, Hauser JF, Kardaris E. Relationships between radiographic alveolar bone height and probing attachment level: Data from healthy post-menopausal women. J Clin Periodontol 2000;27(5):341-346.
  • Shen EC, Gau CH, Hsieh YD, Chang CY, Fu E. Periodontal status in post-menopausal osteoporosis: A preliminary clinical study in taiwanese women. J Chin Med Assoc 2004;67(8):389-393.
  • Tezal M, Wactawski-Wende J, Grossi SG, Ho AW, Dunford R, Genco RJ. The relationship between bone mineral density and periodontitis in postmenopausal women. J Periodontol 2000;71(9):1492-1498.
  • Daltaban O, Saygun I, Bal B, Balos K, Serdar M. Gingival crevicular fluid alkaline phosphatase levels in postmenopausal women: Effects of phase i periodontal treatment. J Periodontol 2006;77(1):67-72.
  • Norderyd OM, Grossi SG, Machtei EE, Zambon JJ, Hausmann E, Dunford RG, Genco RJ. Periodontal status of women taking postmenopausal estrogen supplementation. J Periodontol 1993;64(10):957-962.
  • Lopez-Marcos JF, Garcia-Valle S, Garcia-Iglesias AA. Periodontal aspects in menopausal women undergoing hormone replacement therapy. Med Oral Patol Oral Cir Bucal 2005;10(2):132-141.
  • Silness J, Loe H. Periodontal disease in pregnancy. Ii. Correlation between oral hygiene and periodontal condtion. Acta Odontol Scand 1964;22:(121-135).
  • Muhlemann HR, Son S. Gingival sulcus bleeding--a leading symptom in initial gingivitis. Helv Odontol Acta 1971;15(2):107-113.
  • Pilgram TK, Hildebolt CF, Yokoyama-Crothers N, Dotson M, Cohen SC, Hauser JF, Kardaris E. Relationships between longitudinal changes in radiographic alveolar bone height and probing depth measurements: Data from postmenopausal women. J Periodontol 1999;70(8):829-833.
  • Mohammad AR, Brunsvold M, Bauer R. The strength of association between systemic postmenopausal osteoporosis and periodontal disease. Int J Prosthodont 1996;9(5):479-483.
  • Mealey BL, Moritz AJ. Hormonal influences: Effects of diabetes mellitus and endogenous female sex steroid hormones on the periodontium. Periodontol 2000 2003;32:(59-81).
  • Garcia RI, Henshaw MM, Krall EA. Relationship between periodontal disease and systemic health. Periodontol 2000 2001;25(21-36).
  • Straub RH. The complex role of estrogens in inflammation. Endocr Rev 2007;28(5):521-574.
There are 46 citations in total.

Details

Primary Language English
Journal Section Original Research Articles
Authors

Ali Çekici

Ülkü Başer

Gülden Işık

Süleyman Akhan This is me

Halim İşsever

Utku Onan This is me

Publication Date August 5, 2015
Published in Issue Year 2015 Volume: 49 Issue: 3

Cite

APA Çekici, A., Başer, Ü., Işık, G., Akhan, S., et al. (2015). PERIODONTAL TREATMENT OUTCOMES IN POST MENOPAUSAL WOMEN RECEIVING HORMONE REPLACEMENT THERAPY. Journal of Istanbul University Faculty of Dentistry, 49(3), 39-44. https://doi.org/10.17096/jiufd.61637
AMA Çekici A, Başer Ü, Işık G, Akhan S, İşsever H, Onan U. PERIODONTAL TREATMENT OUTCOMES IN POST MENOPAUSAL WOMEN RECEIVING HORMONE REPLACEMENT THERAPY. J Istanbul Univ Fac Dent. October 2015;49(3):39-44. doi:10.17096/jiufd.61637
Chicago Çekici, Ali, Ülkü Başer, Gülden Işık, Süleyman Akhan, Halim İşsever, and Utku Onan. “PERIODONTAL TREATMENT OUTCOMES IN POST MENOPAUSAL WOMEN RECEIVING HORMONE REPLACEMENT THERAPY”. Journal of Istanbul University Faculty of Dentistry 49, no. 3 (October 2015): 39-44. https://doi.org/10.17096/jiufd.61637.
EndNote Çekici A, Başer Ü, Işık G, Akhan S, İşsever H, Onan U (October 1, 2015) PERIODONTAL TREATMENT OUTCOMES IN POST MENOPAUSAL WOMEN RECEIVING HORMONE REPLACEMENT THERAPY. Journal of Istanbul University Faculty of Dentistry 49 3 39–44.
IEEE A. Çekici, Ü. Başer, G. Işık, S. Akhan, H. İşsever, and U. Onan, “PERIODONTAL TREATMENT OUTCOMES IN POST MENOPAUSAL WOMEN RECEIVING HORMONE REPLACEMENT THERAPY”, J Istanbul Univ Fac Dent, vol. 49, no. 3, pp. 39–44, 2015, doi: 10.17096/jiufd.61637.
ISNAD Çekici, Ali et al. “PERIODONTAL TREATMENT OUTCOMES IN POST MENOPAUSAL WOMEN RECEIVING HORMONE REPLACEMENT THERAPY”. Journal of Istanbul University Faculty of Dentistry 49/3 (October 2015), 39-44. https://doi.org/10.17096/jiufd.61637.
JAMA Çekici A, Başer Ü, Işık G, Akhan S, İşsever H, Onan U. PERIODONTAL TREATMENT OUTCOMES IN POST MENOPAUSAL WOMEN RECEIVING HORMONE REPLACEMENT THERAPY. J Istanbul Univ Fac Dent. 2015;49:39–44.
MLA Çekici, Ali et al. “PERIODONTAL TREATMENT OUTCOMES IN POST MENOPAUSAL WOMEN RECEIVING HORMONE REPLACEMENT THERAPY”. Journal of Istanbul University Faculty of Dentistry, vol. 49, no. 3, 2015, pp. 39-44, doi:10.17096/jiufd.61637.
Vancouver Çekici A, Başer Ü, Işık G, Akhan S, İşsever H, Onan U. PERIODONTAL TREATMENT OUTCOMES IN POST MENOPAUSAL WOMEN RECEIVING HORMONE REPLACEMENT THERAPY. J Istanbul Univ Fac Dent. 2015;49(3):39-44.