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Effect of Prophylactic Vitamin D Supplementation on Postoperative Pain and Sedation in Children with Mental Motor Retarded Who Undergoing Dental Treatment Introduction

Year 2023, , 67 - 74, 30.04.2023

Ebru Biricik , Nilgün Alpay , Feride Karacaer , Volkan Ciftci , Murat Türkeün Ilgınel , Ozlem Goruroglu Ozturk , Dilek Özcengiz

https://doi.org/10.36516/jocass.1216326

Abstract

Öz
Amaç: Mental motor retardasyonu (MMR) olan çocuklarda D vitamini eksikliği sıklığı daha yüksektir. Bu çalışmada genel anestezi altında diş tedavisi uygulanan MMR çocuklarda D vitamini takviyesinin postoperatif ağrı üzerine etkisini araştırmayı amaçladık.
Gereç-Yöntem: Yaşları 7-17 arasında değişen MMR'li toplam 62 hastaya diş tedavisi planlandı. Katılımcılar iki gruba ayrıldı. Çocuklara D vitamini (günde 600 IU D vitamini) veya Salin reçete edildi. Serum D vitamini düzeyleri ölçüldü. Katılımcılar oral D vitamini 600 IU (Grup D) veya 2 ml salin (Grup C) alımını 12. hafta boyunca devam ettirdiler. Tüm katılımcılar postoperatif 1. saate kadar gözlendi ve Non-communicating Children’s Pain Checklist–Postoperative Version (NCCPC-PV), Ramsay sedasyon skorları, anestezi sonrası bakım ünitesinde kalış süreleri, analjezik gereksinimleri kaydedildi.
Bulgular: Çalışma elli çocuk (Grup D' de 35, Grup C' de 15) ile tamamlandı. 12. hafta serum D vitamini düzeyleri Grup D' de Grup C' ye göre yüksekti (p=0,007). İlk başvuruda Grup D’ de 13 (%37,1) Grup C’ de 6 (%40) hastada D vitamini eksikliği, grup D’ de 8 (%51,4) ve Grup C’ de 7 (%46,7) hastada D vitamini yetersizliği. PACU' da 15., 30. ve 60. dakikalarda NCCPC-PV skorunda gruplar arasında istatistiksel olarak anlamlı fark vardı (p<0.05). Ancak Ramsey skorları tüm zamanlarda iki grup arasında benzerdi.
Sonuç: MMR çocuklarda serum D vitamini düzeyleri düşük olarak tespit edildi. D vitamini takviyesinin postoperatif 1. saatte ağrı skorlarını azaltabildiği gözlemlendi.

Keywords

postoperatif analjezi vitamin D mental motor retardasyon

References

  • 1. Durkin M, Schupf N, Stein Z et al. Mental retarda¬tion. In. Wallace R, editor. Stamford, CT: Apple¬ton & Lange; Public health and preventive medi¬cine. 2007:1173-84.
  • 2. Taylor SN. Vitamin D in Toddlers, Preschool Chil-dren, and Adolescents. Ann Nutr Metab. 2020; 76: 30-41. https://doi.org/10.1159/000505635
  • 3. Harvey RA, Champe PC. Biyokimya Lippincott's Illustrated Reviews (Çev. Edt. Ulukaya E.) 5. Ün-ite Metabolizmasının düzenlenmesi, 28. Bölüm Vitaminler (Çev: Delen Akçay Y), 3.baskı, İstan-bul: Nobel Tıp Yayınevi; 2007: 384-87.
  • 4. Akpinar P. Vitamin D status of children with cere-bral palsy: Should vitamin D levels be checked in children with cerebral palsy? North Clin Istanb. 2018;5:341-7. https://doi.org/10.14744/nci.2017.09581
  • 5. Manohar S, Gangadaran RP. Vitamin D status in children with cerebral palsy. Int J Contemp Pedi-atr. 2017; 4: 615.
  • 6. Seth A, Aneja S, Singh R et al. Effect of impaired ambulation and anti-epileptic drug intake on vita¬min D status of children with cerebral palsy. Pae¬diatr Int Child Health. 2017;37: 193-8. https://doi.org/10.1080/20469047.2016.1266116
  • 7. Straube S, Derry S, Moore RA et al. Vitamin D for the treatment of chronic painful conditions in adults. The Cochrane Database of Systematic Re¬views. 2010;(1)CD007771 https://doi.org/10.1002/14651858.CD007771.pub2
  • 8. Huang W, Shah S, Long Q et al. Improvement of pain, sleep, and quality of life in chronic pain pa-tients with vitamin D supplementation. Clin J Pain. 2013;29:341-7. https://doi.org/10.1097/AJP.0b013e318255655d
  • 9. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-81. https://doi.org/10.1056/NEJMra070553
  • 10. Van Veldhuizen PJ, Taylor SA, Williamson S et al. Treatment of vitamin D deficiency in patients with metastatic prostate cancer may improve bone pain and muscle strength. J of Urol. 2000;163:187-90. https://doi.org/10.1016/S0022-5347(05)68001-9
  • 11. Shams T, Al Wadani H, El-Masry R et al. Effect of prophylactic vitamin D on anesthetic outcome in children with sickle cell disease. Anaesthesiol Clin Pharmacol. 2014;30:20-4. https://doi.org/10.4103/0970-9185.125692
  • 12. Bose S, Khanna A, You J et al. Low serum vitamin D levels are not associated with increased postop¬erative pain and opioid requirements: a historical cohort study. Can J Anesth. 2015;62:770-6. https://doi.org/10.1007/s12630-015-0357-4
  • 13. Hajimohammadebrahim-Ketabforoush M, Shahmohammadi M, Khoundabi B et al. Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial. World Neurosurg. 2019;130:105-11. https://doi.org/10.1016/j.wneu.2019.05.250
  • 14. Rusińska A, Płudowski P, Walczak M et al. Vita-min D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Defi¬ciency in Poland-Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel with Participation of Na¬tional Specialist Consultants and Representatives of Scientific Societies-Update. Front Endocrinol. 2018;9:246. https://doi.org/10.3389/fendo.2018.00246
  • 15. Breau LM, Finley GA, McGrath PJ et al. Valida-tion of the non-communicative pain checklist-postoperative version. Anesthesiology 2002; 96:528-35. https://doi.org/10.1097/00000542-200203000-00004
  • 16. Mason KP, Michna E, Zurakowski D et al. Value of bispectral index monitor in differentiating be-tween moderate and deep Ramsay Sedation Scores in children. Paediatr Anaesth. 2006;16:1226-31. https://doi.org/10.1111/j.1460-9592.2006.01975.x
  • 17. Aldrete JA, Kroulik D. A postanesthetic recovery score. Anesth Analg. 1970;49:924. https://doi.org/10.1213/00000539-197011000-00020
  • 18. Munns CF, Shaw N, Kiely M al. Global Consensus Recommendations on Prevention and Manage¬ment of Nutritional Rickets. J Clin Endocrinol Metab. 2016;101:394-415. https://doi.org/10.1210/jc.2015-2175
  • 19. Botelho J, Machado V, Proença L et al. Vitamin D Deficiency and Oral Health: A Comprehensive Re¬view. Nutrients. 2020;19;12:1471. https://doi.org/10.3390/nu12051471
  • 20. Bashutski JD, Eber RM, Kinney JS et al. The Im-pact of Vitamin D Status on Periodontal Surgery Outcomes. J Dent Res. 2011;90:1007-12. https://doi.org/10.1177/0022034511407771
  • 21. Le Roy C, Barja S, Sepúlveda C et al. Vitamin D and iron deficiencies in children and adolescents with cerebral palsy. Neurologia (Engl Ed). 2021;36:112-8. https://doi.org/10.1016/j.nrl.2017.11.005
  • 22. Schwalfenberg G. Improvement of chronic back pain or failed back surgery with vitamin D reple-tion: a case series. J Am Board Fam Med. 2009;22:69-74. https://doi.org/10.3122/jabfm.2009.01.080026
  • 23. Lee A, Chan SKC, Samy W et al. Effect of Hypo-vitaminosis D on Postoperative Pain Outcomes and Short-Term Health-Related Quality of Life After Knee Arthroplasty: A Cohort Study. Medi-cine (Baltimore). 2015;94:1812. https://doi.org/10.1097/MD.0000000000001812

Effect of Prophylactic Vitamin D Supplementation on Postoperative Pain and Sedation in Children with Mental Motor Retarded Who Undergoing Dental Treatment Introduction

Year 2023, , 67 - 74, 30.04.2023

Ebru Biricik , Nilgün Alpay , Feride Karacaer , Volkan Ciftci , Murat Türkeün Ilgınel , Ozlem Goruroglu Ozturk , Dilek Özcengiz

https://doi.org/10.36516/jocass.1216326

Abstract

The frequency of vitamin D deficiency is higher in children with mental motor retardation(MMR). We aimed to investigate the effect of vitamin D supplementation on postoperative pain in children with MMR who underwent dental treatment under general anesthesia.
Materials-Methods: Dental treatment was planned for a total of 62 patients with MMR, aged 7-17 years. Participants were divided into two groups. Children were prescribed vitamin D (600 IU of vitamin D per day) or Saline. Serum vitamin D levels were measured. Participants continued to intake oral vitamin D 600 IU (Group D) or 2ml saline (Group C) throughout 12 weeks. All participants were observed postoperative 1st hour, and Non-communicating Children's Pain Checklist–Postoperative Version (NCCPC-PV), Ramsay sedation scores, length of stay in post-anesthesia care unit, and analgesic requirements were recorded.
Results: The study was completed with fifty children (35 in Group D, 15 in Group C). Serum vitamin D levels were higher in Group D than Group C at 12 weeks(p=0.007). Vitamin D deficiency was found at 13 patients (37.1%) and 6 (40%), and vitamin D sufficiency was found 18 (51.4%) and 7 (46.7%) in Groups D and C, respectively at first admission. There was statistically significant difference between groups in NCCPC-PV score at 15th, 30th and 60th minutes in PACU(p<0.05). However, Ramsey scores were similar between two groups at all times.
Conclusion: Serum vitamin D levels were found to be low in MMR children. It was observed that vitamin D supplementation could reduce pain scores in 1st postoperative hour.

Keywords

Postoperative analgesia vitamin D mental motor retardation

References

  • 1. Durkin M, Schupf N, Stein Z et al. Mental retarda¬tion. In. Wallace R, editor. Stamford, CT: Apple¬ton & Lange; Public health and preventive medi¬cine. 2007:1173-84.
  • 2. Taylor SN. Vitamin D in Toddlers, Preschool Chil-dren, and Adolescents. Ann Nutr Metab. 2020; 76: 30-41. https://doi.org/10.1159/000505635
  • 3. Harvey RA, Champe PC. Biyokimya Lippincott's Illustrated Reviews (Çev. Edt. Ulukaya E.) 5. Ün-ite Metabolizmasının düzenlenmesi, 28. Bölüm Vitaminler (Çev: Delen Akçay Y), 3.baskı, İstan-bul: Nobel Tıp Yayınevi; 2007: 384-87.
  • 4. Akpinar P. Vitamin D status of children with cere-bral palsy: Should vitamin D levels be checked in children with cerebral palsy? North Clin Istanb. 2018;5:341-7. https://doi.org/10.14744/nci.2017.09581
  • 5. Manohar S, Gangadaran RP. Vitamin D status in children with cerebral palsy. Int J Contemp Pedi-atr. 2017; 4: 615.
  • 6. Seth A, Aneja S, Singh R et al. Effect of impaired ambulation and anti-epileptic drug intake on vita¬min D status of children with cerebral palsy. Pae¬diatr Int Child Health. 2017;37: 193-8. https://doi.org/10.1080/20469047.2016.1266116
  • 7. Straube S, Derry S, Moore RA et al. Vitamin D for the treatment of chronic painful conditions in adults. The Cochrane Database of Systematic Re¬views. 2010;(1)CD007771 https://doi.org/10.1002/14651858.CD007771.pub2
  • 8. Huang W, Shah S, Long Q et al. Improvement of pain, sleep, and quality of life in chronic pain pa-tients with vitamin D supplementation. Clin J Pain. 2013;29:341-7. https://doi.org/10.1097/AJP.0b013e318255655d
  • 9. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-81. https://doi.org/10.1056/NEJMra070553
  • 10. Van Veldhuizen PJ, Taylor SA, Williamson S et al. Treatment of vitamin D deficiency in patients with metastatic prostate cancer may improve bone pain and muscle strength. J of Urol. 2000;163:187-90. https://doi.org/10.1016/S0022-5347(05)68001-9
  • 11. Shams T, Al Wadani H, El-Masry R et al. Effect of prophylactic vitamin D on anesthetic outcome in children with sickle cell disease. Anaesthesiol Clin Pharmacol. 2014;30:20-4. https://doi.org/10.4103/0970-9185.125692
  • 12. Bose S, Khanna A, You J et al. Low serum vitamin D levels are not associated with increased postop¬erative pain and opioid requirements: a historical cohort study. Can J Anesth. 2015;62:770-6. https://doi.org/10.1007/s12630-015-0357-4
  • 13. Hajimohammadebrahim-Ketabforoush M, Shahmohammadi M, Khoundabi B et al. Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial. World Neurosurg. 2019;130:105-11. https://doi.org/10.1016/j.wneu.2019.05.250
  • 14. Rusińska A, Płudowski P, Walczak M et al. Vita-min D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Defi¬ciency in Poland-Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel with Participation of Na¬tional Specialist Consultants and Representatives of Scientific Societies-Update. Front Endocrinol. 2018;9:246. https://doi.org/10.3389/fendo.2018.00246
  • 15. Breau LM, Finley GA, McGrath PJ et al. Valida-tion of the non-communicative pain checklist-postoperative version. Anesthesiology 2002; 96:528-35. https://doi.org/10.1097/00000542-200203000-00004
  • 16. Mason KP, Michna E, Zurakowski D et al. Value of bispectral index monitor in differentiating be-tween moderate and deep Ramsay Sedation Scores in children. Paediatr Anaesth. 2006;16:1226-31. https://doi.org/10.1111/j.1460-9592.2006.01975.x
  • 17. Aldrete JA, Kroulik D. A postanesthetic recovery score. Anesth Analg. 1970;49:924. https://doi.org/10.1213/00000539-197011000-00020
  • 18. Munns CF, Shaw N, Kiely M al. Global Consensus Recommendations on Prevention and Manage¬ment of Nutritional Rickets. J Clin Endocrinol Metab. 2016;101:394-415. https://doi.org/10.1210/jc.2015-2175
  • 19. Botelho J, Machado V, Proença L et al. Vitamin D Deficiency and Oral Health: A Comprehensive Re¬view. Nutrients. 2020;19;12:1471. https://doi.org/10.3390/nu12051471
  • 20. Bashutski JD, Eber RM, Kinney JS et al. The Im-pact of Vitamin D Status on Periodontal Surgery Outcomes. J Dent Res. 2011;90:1007-12. https://doi.org/10.1177/0022034511407771
  • 21. Le Roy C, Barja S, Sepúlveda C et al. Vitamin D and iron deficiencies in children and adolescents with cerebral palsy. Neurologia (Engl Ed). 2021;36:112-8. https://doi.org/10.1016/j.nrl.2017.11.005
  • 22. Schwalfenberg G. Improvement of chronic back pain or failed back surgery with vitamin D reple-tion: a case series. J Am Board Fam Med. 2009;22:69-74. https://doi.org/10.3122/jabfm.2009.01.080026
  • 23. Lee A, Chan SKC, Samy W et al. Effect of Hypo-vitaminosis D on Postoperative Pain Outcomes and Short-Term Health-Related Quality of Life After Knee Arthroplasty: A Cohort Study. Medi-cine (Baltimore). 2015;94:1812. https://doi.org/10.1097/MD.0000000000001812
There are 23 citations in total.

Details

Primary Language English
Subjects Anaesthesiology
Journal Section Articles
Authors

Ebru Biricik 0000-0002-3355-198X

Nilgün Alpay 0000-0003-3210-6320

Feride Karacaer 0000-0002-1048-6505

Volkan Ciftci 0000-0001-7365-9365

Murat Türkeün Ilgınel 0000-0001-9183-9124

Ozlem Goruroglu Ozturk 0000-0001-9325-5296

Dilek Özcengiz 0000-0002-2598-0127

Publication Date April 30, 2023
Acceptance Date February 27, 2023
Published in Issue Year 2023

Cite

APA Biricik, E., Alpay, N., Karacaer, F., Ciftci, V., et al. (2023). Effect of Prophylactic Vitamin D Supplementation on Postoperative Pain and Sedation in Children with Mental Motor Retarded Who Undergoing Dental Treatment Introduction. Journal of Cukurova Anesthesia and Surgical Sciences, 6(1), 67-74. https://doi.org/10.36516/jocass.1216326
https://dergipark.org.tr/tr/download/journal-file/11303