Combination Of Lymphocyte Count and Albumin Concentration As A New Prognostic Biomarker For Gastric Cancer

Year 2024, Volume: 7 Issue: 2, 73 - 77, 30.06.2024

Uğur Topal , Orçun Yalav , Burak Yavuz , İsmail Cem Eray , Abdullah Ülkü , Gürhan Sakman , Cem Kağan Parsak

https://doi.org/10.36516/jocass.1448188

Abstract

Aim
This research links systemic inflammation and nutritional status with gastric cancer prognosis and postoperative outcomes.
Methods
Patients undergoing total gastrectomy for gastric adenocarcinoma (2015-2018) were categorized into two: Low Lymphocyte–Albumin(LA) score (Group 1) and High Lymphocyte-Albumin score (Group 2). Demographics, clinical data, operative outcomes, and survival rates were compared. The LA score's predictive ability for lymph node positivity was assessed.
Results
Using a cut-off value of 6069.7, Group 1 had 59 patients (low value) and Group 2 had 45 (high value). Hospital readmissions due to wound infections were higher in Group 1 (16.9% vs. 2.2%, p=0.041). Both groups had similar tumor localization and total lymph nodes removed, but Group 1 had more positive lymph nodes (4 vs. 2, p=0.026). Survival rates were comparable (32.59 vs. 31.32 months, p=0.390).
Conclusion
Low LA scores correlate with a higher number of positive lymph nodes, serving as a postoperative quality assessment indicator.

Keywords

Gastric Cancer, Prognosis, Complication, Albumin, Lymphocyte Count

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