Comparison of De Ritis Rate for Del Nido Versus Blood Cardioplegia in Patients Who Underwent Coronary Artery Bypass Graft Under Cardiopulmonary Bypass

Year 2024, Volume: 7 Issue: 3, 144 - 148, 30.09.2024

Bişar Amaç , Murat Ziya Bağış , Mahmut Padak

https://doi.org/10.36516/jocass.1513739

Abstract

Aim: Within the scope of this research, we aimed to compare the liver function tests, liver enzymes and De Ritis ratio (AST/ALT) of patients given Del Nido cardioplegia and blood cardioplegia in coronary heart surgery.
Methods: This retrospective study included a total of 80 patients who underwent CPB-guided coronary heart surgery (CABG) with 40 Del Nido cardioplegia solutions and 40 blood cardioplegia solutions. CPB-guided coronary heart surgery patients given Del Nido cardioplegia solution were determined as the first group (Group 1), and patients given blood cardioplegia were determined as the second group (Group 2).
Results: Preoperative and postoperative aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, direct bilirubin, and gamma-glutamyl transferase (GGT) levels of the groups were similar (p<0.005). AST, ALT, total bilirubin, direct bilirubin, and GGT levels were similar in CPB output (p<0.005). The De Ritis ratio of the groups was similar on the preoperative and postoperative 1st day (p=0.072; p=0.687, respectively), and the rate of ritis at CPB output was higher in group 2 (p=0.003). The requirement for defibrillation was higher in group 1 (p=0.044).
Conclusion: The Del Nido cardioplegia solution may be superior to blood cardioplegia in CABG cases accompanied by CPB regarding the De Ritis ratio.

Keywords

Cardiopulmonary bypass, coronary artery bypass graft, del nido cardioplegia, blood cardioplegia, de ritis rate

Ethical Statement

In this study; before the study, approval was obtained from the institution where the study will be conducted (Sanliurfa Mehmet Akif Inan Training and Research Hospital) and the local ethics committee (Harran University Clinical Research Ethics Committee) (Date: 10.04.2023 - Approval no: HRÜ/23.06.04). As this was a retrospective research, no informed consent has been obtained from participants. The study was conducted in accordance with the principles of the Declaration of Helsinki.

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