Quantitative Ultrasound Measurements of Common Carotid Artery Blood Flow Velocity Patterns in Patients with Coronary Slow Flow

Year 2018, Volume: 4 Issue: 2, 117 - 125, 29.06.2018

Lütfü Aşkın , Mustafa Çetin Serdar Türkmen Mehmet Hakan Tasolar Erdal Aktürk

Abstract

Amaç: Koroner yavaş akımlı (CSF) hastalarda karotis akım hızı (CFV) değişkenlerini analiz etmeyi amaçladık.

Yöntem Çalışmaya anjiyografi k olarak normal koroner arter yapısına sahip CSF' lu 66 hasta ve normal koroner arter ve normal kan akımına sahip

53 kontrol alındı. Koroner akım, miyokard İnfarktüsü frame Sayımı (cTFC) için düzeltilmiş tromboliz ile ölçümü ile hesaplandı. İntima

media kalınlığı (IMT) ve CFV ölçüldü. Brakiyal arter endotel bağımlı dilasyon (EDD) hesaplandı.

Bulgular IMT, pulsatilite indeksi (PI) ve direnç indeksi (RI) CSF grubunda anlamlı derecede yüksek, aksine pik sistolik hız (PSV), uç diyastolik hız

(EDV), ortalama hız (MV), çapa bağlı akımda yükselme (FMID), EDD, nitrogliserinle indüklenen dilatasyon (NID) ve hiperemi anlamlı

olarak bu grupta düşük izlendi (p < 0,001, hepsi için). Spearman korelasyon analizi karotid arter kan akım hızı paternleri ile CSF arasında

orta derecede güçlü bir ilişki olduğunu göstermiştir (p <0,05, hepsi için).

Sonuç CSF' lu hastalarda CFV azalmıştır. CSF' da olduğu gibi karotis akış hızındaki azalmanın nedenleri, endotel disfonksiyonu, mikrovasküler

direnç ve küçük damar hastalığı olabilir

Keywords

koroner yavaş akım, uç diyastolik hız, pik sistolik hız, pulsatilite indeksi

References

• 1. Chaudhry MA, Smith M, Hanna EB, et al. Diverse spectrum of presentation of coronary slow fl ow phenomenon: a concise review of the literature. Cardiol Res Pract 2012; 2012.
• 2. Mangieri E, Macchiarelli G, Ciavolella M, et al. Slow coronary fl ow: clinical and histopathological features in patients with otherwise normal epicardial coronary arteries. Cathet Cardiovasc Diagn 1996; 37:375-381.
• 3. Chatzizisis YS, Coskun AU, Jonas M, et al. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol 20072007; 49:2379-2393.
• 4. Gazi E, Barutcu A, Altun B, et al. Intercellular adhesion molecule-1 K469E and angiotensinogen T207M polymorphisms in coronary slow fl ow. Med Princ Pract 2014; 23:346-350.
• 5. Tasal A, Bacaksiz A, Ertas G, et al. Association between serum cystatin C levels and coronary slow fl ow. Angiology 2014; 65:831-837.
• 6. Cin VG, Pekdemir H, Çamsar A, et al. Diffuse intimal thickening of coronary arteries in slow coronary fl ow. Jpn Heart J 2003; 44:907-919.
• 7. Mosseri M, Yarom R, Gotsman M, et al. Histologic evidence for smallvessel coronary artery disease in patients with angina pectoris and patent large coronary arteries. Circulation 1986; 74:964-972.
• 8. Gibson CM, Cannon CP, Daley WL, et al. TIMI frame count a quantitative method of assessing coronary artery fl ow. Circulation 1996; 93:879- 888.
• 9. Celermajer DS, Sorensen KE, Gooch V, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. The lancet 1992; 340:1111-1115.
• 10. Mikkonen R, Kreula J, Virkkunen P. Peak Systolic Velocity, Resistance Index and Pulsatility Index Variations in measuring a pre-recorded videotape. Acta radiol 1997; 38:598-602.
• 11. Hertzer NR, Young JR, Beven EG, et al. Coronary angiography in 506 patients with extracranial cerebrovascular disease. Arch Intern Med 1985; 145:849-852.
• 12. Wolf PA, Kannel WB, Sorlie P. Asymptomatic carotid bruit and risk of stroke: the Framingham study. Jama 1981; 245:1442-1445.
• 13. Sahn DJ, DeMaria A, Kisslo J, et al. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978; 58:1072-1083.
• 14. Woo KS, McCrohon JA, Chook P, et al. Chinese adults are less susceptible than whites to age-related endothelial dysfunction. J Am Coll Cardiol 1997; 30:113-118.
• 15. Neunteufl T, Heher S, Katzenschlager R, et al. Late prognostic value of fl ow-mediated dilation in the brachial artery of patients with chest pain. Am J Cardiol 2000; 86:207-210.
• 16. Corretti MC, Plotnick GD, Vogel RA. Technical aspects of evaluating brachial artery vasodilatation using high-frequency ultrasound. Am J Physiol Heart Circ Physiol 1995; 268:1397-1404.
• 17. Miura K, Kato M, Dote K, et al. Association of nonculprit plaque characteristics with transient slow fl ow phenomenon during percutaneous coronary intervention. Int J Cardiol 2015; 181:108-113.
• 18. Tambe A, Demany M, Zimmerman HA, et al. Angina pectoris and slow fl ow velocity of dye in coronary arteries—a new angiographic fi nding. Am Heart J 1972; 84:66-71.
• 19. Sezgin N, Barutcu I, Sezgin AT, et al. Plasma nitric oxide level and its role in slow coronary fl ow phenomenon. Int Heart J 2005; 46:373-382.
• 20. Humphrey JD. Mechanisms of arterial remodeling in hypertension coupled roles of wall shear and intramural stress. Hypertension 2008; 52:195-200.
• 21. Celermajer DS. Endothelial dysfunction: does it matter? Is it reversible? J Am Coll Cardiol 1997; 30:325-333.
• 22. Al Suwaidi J, Hamasaki S, Higano ST, et al. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 2000; 101:948-954.
• 23. Schächinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000; 101:1899-1906.
• 24. Furumoto T, Fujii S, Saito N, et al. Relationships between brachial artery fl ow mediated dilation and carotid artery intima-media thickness in patients with suspected coronary artery disease. Jpn Heart J 2002; 43:117-125.
• 25. Halcox JP, Donald AE, Ellins E, et al. Endothelial function predicts progression of carotid intima-media thickness. Circulation 2009; 119:1005- 1012.
• 26. Enderle M, Schroeder S, Ossen R, et al. Comparison of peripheral endothelial dysfunction and intimal media thickness in patients with suspected coronary artery disease. Heart 1998; 80:349-354.
• 27. Hunink M, Polak J, Barlan MM, et al. Detection and quantifi cation of carotid artery stenosis: effi cacy of various Doppler velocity parameters. AJR Am J Roentgenol 1993; 160:619-625.
• 28. Crouse JR, Toole JF, McKinney WM, et al. Risk factors for extracranial carotid artery atherosclerosis. Stroke 1987; 18:990-996.
• 29. Grotta J, Yatsu P, Pettigrew L, et al. Prediction of carotid stenosis progression by lipid and hematologic measurements. Neurology 1989; 39:1325-1325.
• 30. O’Leary DH, Polak JF, Wolfson SK, et al. Use of sonography to evaluate carotid atherosclerosis in the elderly. The Cardiovascular Health Study. CHS Collaborative Research Group. Stroke 1991; 22:1155-1163.
• 31. Bai CH, Chen JR, Chiu HC, et al. Lower blood fl ow velocity, higher resistance index, and larger diameter of extracranial carotid arteries are associated with ischemic stroke independently of carotid atherosclerosis and cardiovascular risk factors. J Clin Ultrasound 2007; 35:322-330.
• 32. Fukuhara T, Hida K, Manabe Y, et al. Reduced fl ow velocity in the internal carotid artery independently of cardiac hemodynamics in patients with cerebral ischemia. J Clin Ultrasound 2007; 35:314-321.
• 33. Owolabi MO, Agunloye AM, Ogunniyi A. The relationship of fl ow velocities to vessel diameters differs between extracranial carotid and vertebral arteries of stroke patients. J Clin Ultrasound 2014; 42:16-23.
• 34. Jackson S, Vyas S. A double􀀀blind, placebo controlled study of postmenopausal oestrogen replacement therapy and carotid artery pulsatility index. BJOG: Int J Gynaecol Obstet 1998; 105:408-412.
• 35. Ray􀀀Chaudhuri K, Ryder S, Thomaides T, et al. The relationship between blood fl ow and pulsatility index in the superior mesenteric artery at rest and during constrictor stimuli in normal subjects. J Clin Ultrasound 1994; 22:149-160.
• 36. Staub D, Meyerhans A, Bundi B, et al. Prediction of cardiovascular morbidity and mortality comparison of the internal carotid artery resistive index with the common carotid artery intima-media thickness. Stroke