Adjuvan mitomisin-C ile cerrahi eksizyon sonrası konjonktival papillomlu hastalarda kuru göz parametrelerinin değerlendirilmesi

Year 2023, Volume: 4 Issue: 2, 112 - 116, 27.03.2023

Ceyda Başkan , Sabite Emine Gökce

https://doi.org/10.47582/jompac.1255483

Abstract

Amaç: Adjuvan Mitomisin C (MMC) ile cerrahi eksizyonu takiben konjonktival papillomlu hastalarda gözyaşı ozmolarite seviyelerindeki, gözyaşı fonksiyon testlerindeki ve kuru göz semptom skorlarındaki değişiklikleri değerlendirmek
Materyal ve Metod: Konjonktival papilloma tanısı alan 30 hasta çalışmaya alındı. Gözyaşı ozmolaritesi, floresein kırılma zamanı, Schirmer I testi ve göz kapağı menisküs yüksekliği, adjuvan %0.02 MMC ile konjonktival cerrahi öncesinde ve sonrasında 1., 3. ve 6. aylarda değerlendirilerek kaydedildi. Ameliyat öncesi ve sonrası 1., 3., 6. aylarda alınan kuru göz semptom anketi skorları kaydedildi. Her kontrol ziyaretinde kaydedilen test sonuçlarının ortalama değerleri karşılaştırıldı.
Bulgular: Çalışmaya alınan hastaların ortalama yaşı 37 ± 9.5 idi. Schirmer I test skorları, FBUT değerleri, kuru göz semptom skorları, göz kapağı menisküs yüksekliği skorları ve gözyaşı ozmolarite değerleri preoperatif ve kontrol ölçümlerinde anlamlı farklılık gösterdi (p<0.05). Bu fark postoperatif 1. ay kontrolünde daha belirgindi. Ölçüm değerleri, kuruluğun postoperatif 1. ayda en yüksek değere ulaştığını ve sonrasında giderek azalarak postoperatif 6. ayda preoperatif değerlere ulaştığını gösterdi.
Sonuç: Bu çalışma ile MMC ile yapılan konjonktiva cerrahisinin geçici olarak kuru göz semptom skorlarında artışa ve anormal gözyaşı fonksiyon testlerine neden olabileceği gösterilmiştir.

Keywords

konjonktival papillom, mitomisin C, gözyaşı ozmolaritesi, kuru göz hastalığı

Evaluation of dry eye parameters in patients with conjunctival papilloma following surgical excision with adjuvant mitomycin-C

Abstract

Aim: To evaluate the changes in tear osmolarity levels, tear function tests, and dry eye symptom scores in patients with conjunctival papilloma following surgical excision with adjuvant Mitomycin C (MMC).
Material And Method: Thirty patients diagnosed with conjunctival papilloma were enrolled in the study. Tear osmolarity, fluorescein break-up time (FBUT), Schirmer I test and eyelid margin score were evaluated at baseline and 1st, 3rd, and 6th months after conjunctival surgery with adjuvant 0.02% MMC were recorded. Dry eye symptom questionnaire scores obtained preoperatively and at the 1st, 3rd, and 6th months after surgery were also recorded. The mean values of test results noted at each control visit were compared.
Results: The mean age of the study population was 37±9.5 years. Schirmer I test scores, FBUT values, dry eye symptom scores, eyelid margin scores, and tear osmolarity values showed a significant difference between the preoperative measurements and follow-up visits (p<0.05). This difference was more apparent at the postoperative 1st-month visit. Measurement values showed that dryness peaked at the postoperative 1st month and gradually decreased afterward reaching the preoperative values at the postoperative 6th-month visit.
Conclusion: This study showed that conjunctival papilloma surgery with MMC is associated with transiently increased dry eye symptom scores and abnormal tear function tests.

Keywords

conjunctival papilloma, Mitomycin C, tear osmolarity, dry eye disease

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